The DOI matches its Crossref record; 45 of the 47 references it cites were found in a registry or an index.
Sexual Dysfunction in Major Depression
Abstract
Little is known about the prevalence, typology, and natural course of non—drug-induced sexual dysfunction in patients with depression. Loss of libido has been reported in various studies to affect from 25% to 75% of patients with unipolar depression, and its prevalence appears to be correlated with the severity of depression. Disorders of arousal also appear to be relatively common in both men and women with major depression, of whom ~25% may experience problems with erection or lubrication. The scant available data regarding orgasmic difficulties in patients with depression who have not yet taken antidepressant medication suggest that they are more common than in the general population. The potential causes of sexual dysfunction in patients with depression are complex and little investigated, and future research must distinguish and explore the various biological, psychological, and psychosocial factors that are likely to be involved.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Approximately 25% of patients with major depression may experience problems with erection or lubrication (531).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [531]
Citations
Cites
Sexual Dysfunction in the United States: Prevalence and Predictors
Laumann, E. O., Paik, A., & Rosen, R. C. (1999) · JAMA · doi:10.1001/jama.281.6.537 · Cited by 5,119
Freeman, E. W., Sammel, M. D., Lin, H., & Nelson, D. B. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.375 · Cited by 921
Risk for New Onset of Depression During the Menopausal Transition
Cohen, L. S., Soares, C. N., Vitonis, A. F., Otto, M. W., & Harlow, B. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.385 · Cited by 852
Distress about sex: a national survey of women in heterosexual relationships.
Bancroft, J., Loftus, J., & Long, J. S. (2003) · Archives of Sexual Behavior · doi:10.1023/a:1023420431760 · Cited by 774
Factors predisposing women to chronic pelvic pain: systematic review
Latthe, P. M., Mignini, L. E., Gray, R. G., Hills, R. K., & Khan, K. S. (2006) · BMJ · doi:10.1136/bmj.38748.697465.55 · Cited by 591
Araujo, A. B., Durante, R., Feldman, H. A., Goldstein, I., & McKinlay, J. B. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199807000-00011 · Cited by 576
Incidence and prevalence of the sexual dysfunctions: A critical review of the empirical literature
Spector, I. P., & Carey, M. P. (1990) · Archives of Sexual Behavior · doi:10.1007/bf01541933 · Cited by 557
Sexual dysfunction before antidepressant therapy in major depression
Kennedy, S. H., Dickens, S. E., Eisfeld, B. S., & Bagby, R. M. (1999) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00050-6 · Cited by 412
Sexuality during pregnancy and after childbirth
von Sydow, K. (1999) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(98)00106-8 · Cited by 381
Jackson, S. W. (1986) · Yale University Press eBooks · doi:10.2307/j.ctt1xp3stn · Cited by 335
Melancholia and Depression: From Hippocratic Times to Modern Times
Jackson, S. W. (1986) · Medical Entomology and Zoology · Cited by 326
Increased incidence of depressive symptoms in men with erectile dysfunction
Shabsigh, R., Klein, L. T., Seidman, S., Kaplan, S. A., Lehrhoff, B. J., & Ritter, J. S. (1998) · Urology · doi:10.1016/s0090-4295(98)00292-1 · Cited by 296
The Relation Between Mood and Sexuality in Heterosexual Men
Bancroft, J., Janssen, E., Strong, D., Carnes, L., Vukadinovic, Z., & Long, J. S. (2003) · Archives of Sexual Behavior · doi:10.1023/a:1023409516739 · Cited by 285
Casper, R. C. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790340082012 · Cited by 279
Sexual problems in healthy and depressed persons
Angst, J. (1998) · International Clinical Psychopharmacology · doi:10.1097/00004850-199807006-00001 · Cited by 273
Correlates of Circulating Androgens in Mid-Life Women: The Study of Women’s Health Across the Nation
Santoro, N., Torréns, J. I., Crawford, S. L., Allsworth, J. E., Finkelstein, J. S., Gold, E. B., Korenman, S. G., Lasley, W. L., Luborsky, J. L., McConnell, D. S., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2063 · Cited by 251
The ELIXIR study: evaluation of sexual dysfunction in 4557 depressed patients in France
Bonierbale, M., Lançon, C., & Tignol, J. (2003) · Current Medical Research and Opinion · doi:10.1185/030079902125001461 · Cited by 249
The Menopause and Sexual Functioning: A Review of the Population-Based Studies
Dennerstein, L., Alexander, J. L., & Kotz, K. (2003) · Annual Review of Sex Research · doi:10.1080/10532528.2003.10559811 · Cited by 238
Depression and sexual dysfunction
Baldwin, D. S. (2001) · British Medical Bulletin · doi:10.1093/bmb/57.1.81 · Cited by 217
Sexual dysfunctions in depression
Mathew, R. J., & Weinman, M. L. (1982) · Archives of Sexual Behavior · doi:10.1007/bf01541593 · Cited by 196
Medical and psychiatric symptoms in women with childhood sexual abuse.
Walker, E. A., Katon, W. J., Hansom, J., Harrop-Griffiths, J., Holm, L., Jones, M. L., Hickok, L. R., & Jemelka, R. P. (1992) · Psychosomatic Medicine · doi:10.1097/00006842-199211000-00005 · Cited by 193
The Relation Between Mood and Sexuality in Gay Men
Bancroft, J., Janssen, E., Strong, D., & Vukadinovic, Z. (2003) · Archives of Sexual Behavior · doi:10.1023/a:1023461500810 · Cited by 167
McCoy, S. J. B., Beal, J. M., Shipman, S. B. M., Payton, M. E., & Watson, G. H. (2006) · PubMed · Cited by 156
Lifetime Psychopathology in Individuals with Low Sexual Desire
Schreiner-Engel, P., & Schiavi, R. C. (1986) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198611000-00002 · Cited by 155
Delgado, P. L., Brannan, S. K., Mallinckrodt, C. H., Trân, P. V., McNamara, R. K., Wang, F., Watkin, J. G., & Detke, M. J. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0603 · Cited by 135
Nocturnal penile tumescence is diminished in depressed men
Thase, M. E., Reynolds, C. F., Jennings, J. R., Frank, E., Howell, J. R., Houck, P. R., Berman, S., & Kupfer, D. J. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90119-9 · Cited by 99
Hypoactive sexual desire disorder: an underestimated condition in men
MEULEMAN, E. J. H., & van Lankveld, J. J. D. M. (2005) · British Journal of Urology · doi:10.1111/j.1464-410x.2005.05285.x · Cited by 98
Sexual Function in Depressed Men
Nofzinger, E. A. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820130026005 · Cited by 98
Relationships Between Erectile Dysfunction, Depression, and Anxiety in Japanese Subjects
Sugimori, H., Yoshida, K., Tanaka, T., Baba, K., Nishida, T., Nakazawa, R., & Iwamoto, T. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.20354.x · Cited by 90
Mood, depression, and reproductive hormones in the menopausal transition
Schmidt, P. J. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.09.033 · Cited by 87
SEXUAL DYSFUNCTION IN WOMEN WITH HYPERPROLACTINEMIA: A PILOT STUDY REPORT
Kadıoğlu, P., Yalin, A. S., Tiryakioğlu, Ö., Gazioğlu, N., Oral, G., Şanlı, Ö., Önem, K., & Kadıoğlu, A. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000176456.50491.51 · Cited by 81
Nocturnal penile tumescence in depressed men
Thase, M. E., Reynolds, C. F., Glanz, L. M., Jennings, J. R., Sewitch, D. E., Kupfer, D. J., & Frank, E. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.1.89 · Cited by 81
Prospective assessment of sexual function in women treated for recurrent major depression
Cyranowski, J. M., Frank, E., Cherry, C. R., Houck, P. R., & Kupfer, D. J. (2003) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2003.08.003 · Cited by 76
Ekselius, L., & von Knorring, L. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200104000-00006 · Cited by 75
Baldwin, D. S., Bridgman, K. M., & Buis, C. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105056666 · Cited by 72
PSYCHIATRIC MORBIDITY IS FREQUENTLY UNDETECTED IN PATIENTS WITH ERECTILE DYSFUNCTION
Mallis, D., Moysidis, K., Nakopoulou, E., Papaharitou, S., Konstantinos Hatzimouratidis, A., & Hatzichristou, D. G. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000176746.73667.3c · Cited by 63
Zajecka, J., Dünner, D. L., Gelenberg, A. J., Hirschfeld, R. M. A., Kornstein, S. G., Ninan, P. T., Rush, A. J., Thase, M. E., Trivedi, M. H., Arnow, B. A., et al. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0809 · Cited by 63
Erectile dysfunction: prevalence and relationship to depression, alcohol abuse and panic disorder
Okulate, G. T., Oladokun, O., & Dogunro, A. S. (2003) · General Hospital Psychiatry · doi:10.1016/s0163-8343(03)00015-x · Cited by 58
Gender differences in factors associated with hypoactive sexual desire
Donahey, K. M., & Carroll, R. A. (1993) · Journal of Sex & Marital Therapy · doi:10.1080/00926239308404886 · Cited by 53
Kantor, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf142 · Cited by 50
Effect of bromocriptine on affect and libido in hyperprolactinemia
KOPPELMAN, M. C. S., Parry, B. L., Hamilton, J. A., Alagna, S. W., & Loriaux, D. L. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.8.1037 · Cited by 44
Sáiz-Ruiz, J., Montes, J. M. G., Ibáñez, Á., Díaz, M., Vicente, F., Pelegrín, C., Viñas, R., Árias, F., Carrasco, J. L., & Ferrando, L. (2005) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.706 · Cited by 39
The Effects of Estrogen on Brain Function
Rasgon, N. (2006) · Johns Hopkins University Press eBooks · doi:10.1353/book.3239 · Cited by 25
Androgen Status in Healthy Premenopausal Women with Loss of Libido
Nyunt, A., Stephen, G., Gibbin, J., Durgan, L., Fielding, A., Wheeler, M., & Price, D. (2005) · Journal of Sex & Marital Therapy · doi:10.1080/00926230590475314 · Cited by 18
The aging male: androgens, erectile dysfunction, and depression.
Seidman, S. N. (2003) · PubMed · Cited by 11
Research works printed but not linked: 1
- 1994, Diagnostic and Statistical Manual of Mental Disorders
Cited by
Sorted by citations
DE HERT, M., CORRELL, C. U., BOBES, J., CETKOVICH‐BAKMAS, M., COHEN, D., ASAI, I., DETRAUX, J., GAUTAM, S., MÖLLER, H., NDETEI, D. M., et al. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00014.x · Cited by 2,488
“Approximately 25% of patients with major depression may experience problems with erection or lubrication (531).”
BackgroundHypersexual disorder: A proposed diagnosis for DSM-V
Kafka, M. P. (2010) · Archives of Sexual Behavior · doi:10.1007/s10508-009-9574-7 · Cited by 1,095
“Although a decrease in sexual interest and enacted sexual behavior can be associated with major depression (Williams & Reynolds, 2006), increased sexual behavior has been noted in association with depressive disorders as well (Mathew, Largen, & Claghorn, 1979; Mathew & Weinman, 1982).”
BackgroundCarvalho, A. F., Sharma, M. S., Brunoni, A. R., Vieta, E., & Fava, G. A. (2016) · Psychotherapy and Psychosomatics · doi:10.1159/000447034 · Cited by 650
HIV and depression: 2008 review and update
Rabkin, J. G. (2008) · Current HIV/AIDS Reports · doi:10.1007/s11904-008-0025-1 · Cited by 345
Hill, M. N., Carrier, E. J., McLaughlin, R. J., Morrish, A. C., Meier, S. E., Hillard, C. J., & Gorzalka, B. B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05567.x · Cited by 246
Metadata
- Authors
- Williams, K., & Reynolds, M. F.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Williams, Katherine
- ORCID
- Williams, Katherine
- Venue
- CNS Spectrums
- Publisher
- Cambridge University Press (CUP)
- Published
- 2006
- Volume
- 11
- Issue
- S9
- Pages
- 19-23
- ISSN
- 1092-8529 (ISSN-L)
- 2165-6509
- OpenAlex
- W125145245
- Cited by
- 107
- References
- 47
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 5 · 2023: 9 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 2
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS Spectrums (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- sexual dysfunction, major depressive disorder, low libido, arousal disorders, erectile dysfunction, dyspareunia, orgasmic dysfunction, depression severity, prevalence, psychosocial factors, biological factors
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Erectile Dysfunction, Male, Sexual Dysfunction, Physiological, Prevalence, Sexual Dysfunctions, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
