Neuropsychological sequelae of obstructive sleep apnea-hypopnea syndrome: a critical review

ALOIA, MARK S.; ARNEDT, J. TODD; DAVIS, JENNIFER D.; RIGGS, RAINE L.; BYRD, DESIREE

doi:10.1017/s1355617704105134

Cited by 391Obstructive Sleep Apnea ResearchSleep and related disordersSleep and Wakefulness Research

Neuropsychological sequelae of obstructive sleep apnea-hypopnea syndrome: a critical review

ALOIA, MARK S., ARNEDT, J. TODD, DAVIS, JENNIFER D., RIGGS, RAINE L., BYRD, DESIREE·2004·Journal of the International Neuropsychological Society

DOI 10.1017/s1355617704105134

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Abstract

Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a well-recognized clinical sleep disorder that results in chronically fragmented sleep and recurrent hypoxemia. The primary daytime sequelae of the disorder include patient reports of excessive daytime sleepiness, depression, and attention and concentration problems. It has been well established that OSAHS negatively impacts certain aspects of cognitive functioning. The primary goals of this article are to (1) clarify the pattern of cognitive deficits that are specific to OSAHS; (2) identify the specific cognitive domains that improve with treatment; and (3) elucidate the possible mechanisms of cognitive dysfunction in OSAHS. At the conclusion of the paper, we propose a potential neurofunctional theory to account for the etiology of cognitive deficits in OSAHS. Thirty-seven peer-reviewed articles were selected for this review. In general, findings were equivocal for most cognitive domains. Treatment, however, was noted to improve attention/vigilance in most studies and consistently did not improve constructional abilities or psychomotor functioning. The results are discussed in the context of a neurofunctional theory for the effects of OSAHS on the brain.

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Sleep-Disordered Breathing, Hypoxia, and Risk of Mild Cognitive Impairment and Dementia in Older Women
Yaffe, K., Laffan, A. M., Harrison, S. L., Redline, S., Spira, A. P., Ensrud, K. E., Ancoli-Israel, S., & Stone, K. L. (2011) · JAMA · doi:10.1001/jama.2011.1115 · Cited by 1,137 · see citing works
Obstructive Sleep Apnea: Brain Structural Changes and Neurocognitive Function before and after Treatment
Canessa, N., Castronovo, V., Cappa, S. F., Aloia, M. S., Marelli, S., Falini, A., Alemanno, F., & Ferini‐Strambi, L. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201005-0693oc · Cited by 580 · see citing works
Self-citation
The Effect of CPAP in Normalizing Daytime Sleepiness, Quality of Life, and Neurocognitive Function in Patients with Moderate to Severe OSA
Antic, N. A., Catcheside, P., Buchan, C., Hensley, M., Naughton, M. T., Rowland, S., Williamson, B., Windler, S., & McEvoy, R. D. (2011) · Sleep · doi:10.1093/sleep/34.1.111 · Cited by 533 · see citing works
Neurocognitive function in obstructive sleep apnoea: A meta‐review
BUCKS, R. S., OLAITHE, M., & EASTWOOD, P. (2013) · Respirology · doi:10.1111/j.1440-1843.2012.02255.x · Cited by 483 · see citing works
Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment
Leng, Y., McEvoy, C. T., Allen, I. E., & Yaffe, K. S. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.2180 · Cited by 479 · see citing works
Neurobehavioral Morbidity Associated With Disordered Breathing During Sleep in Children: A Comprehensive Review
Beebe, D. W. (2006) · Sleep · doi:10.1093/sleep/29.9.1115 · Cited by 446 · see citing works
Neurocognitive Impairment in Obstructive Sleep Apnea
Lal, C., Strange, C., & Bachman, D. (2012) · Chest · doi:10.1378/chest.11-2214 · Cited by 406 · see citing works
Obstructive sleep apnea, cognition and Alzheimer's disease: A systematic review integrating three decades of multidisciplinary research
Bubu, O. M., Andrade, A. G., Umasabor-Bubu, O. Q., Hogan, M. M., Turner, A. D., de Leon, M. J., Ogedegbe, G., Ayappa, I., Jean-Louis G, G., Jackson, M. L., et al. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2019.101250 · Cited by 389 · see citing works
Cognitive Effects of Treating Obstructive Sleep Apnea in Alzheimer's Disease: A Randomized Controlled Study
Ancoli‐Israel, S., Palmer, B. W., Cooke, J. R., Corey‐Bloom, J., Fiorentino, L., Natarajan, L., Liu, L., Ayalon, L., He, F., & Loredo, J. S. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01934.x · Cited by 379 · see citing works
Cognitive deficits in obstructive sleep apnea: Insights from a meta-review and comparison with deficits observed in COPD, insomnia, and sleep deprivation
Olaithe, M., Bucks, R. S., Hillman, D. R., & Eastwood, P. R. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.03.005 · Cited by 350 · see citing works
International Consensus Statement on Obstructive Sleep Apnea
Chang, J. L., Goldberg, A. N., Alt, J. A., Mohammed, A., Ashbrook, L., Auckley, D., Ayappa, I., Bakhtiar, H., Barrera, J. E., Bartley, B. L., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23079 · Cited by 350 · see citing works
Prevalence and Consequences of Sleep Disorders in Traumatic Brain Injury
Castriotta, R. J., Wilde, M. C., Lai, J. M., Atanasov, S., Masel, B. E., & Kuna, S. T. (2007) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26855 · Cited by 334 · see citing works
Obstructive Sleep Apnea is Linked to Depression and Cognitive Impairment: Evidence and Potential Mechanisms
Kerner, N. A., & Roose, S. P. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.01.134 · Cited by 338 · see citing works
Obstructive sleep apnea syndrome
Mannarino, M. R., Filippo, F. D., & Pirro, M. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.05.013 · Cited by 327 · see citing works
Sleep Disturbance, Cognitive Decline, and Dementia: A Review
Wu, M. N., Rosenberg, P. B., Spira, A. P., & Wennberg, A. M. V. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1604351 · Cited by 310 · see citing works
Cognitive profile and brain morphological changes in obstructive sleep apnea
Torelli, F., Moscufo, N., Garreffa, G., Placidi, F., Romigi, A., Zannino, S., Bozzali, M., Fasano, F., Giulietti, G., Djonlagic, I. E., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.065 · Cited by 296 · see citing works
Obstructive sleep apnea, depression and cognitive impairment
Vaněk, J., Praško, J. P., Genzor, S., Ocisková, M., Kantor, K., Holubová, M., Šlepecký, M., Nesnídal, V., Kolek, A., & Sova, M. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.03.017 · Cited by 303 · see citing works
Depression and Obstructive Sleep Apnea (OSA)
Schroder, C. M., & O'Hara, R. M. (2005) · Annals of General Psychiatry · doi:10.1186/1744-859x-4-13 · Cited by 275 · see citing works
A combined neuropsychological and brain imaging study of obstructive sleep apnea
Yaouhi, K., Bertran, F., Clochon, P., Mézenge, F., Denise, P., Foret, J., Eustache, F., & Desgranges, B. (2009) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00705.x · Cited by 234 · see citing works
Cognitive impairment in obstructive sleep apnea
Gagnon, K., Baril, A., Gagnon, J., Fortin, M., Décary, A., Lafond, C., Désautels, A., Montplaisir, J. Y., & Gosselin, N. (2014) · Pathologie Biologie · doi:10.1016/j.patbio.2014.05.015 · Cited by 231 · see citing works
Normalization of Memory Performance and Positive Airway Pressure Adherence in Memory-Impaired Patients With Obstructive Sleep Apnea
Zimmerman, M. E., Arnedt, J. T., Stanchina, M. L., Millman, R. P., & Aloia, M. S. (2006) · CHEST Journal · doi:10.1378/chest.130.6.1772 · Cited by 230 · see citing works
Self-citation
White Matter Integrity in Obstructive Sleep Apnea before and after Treatment
Castronovo, V., Scifo, P., Castellano, A., Aloia, M. S., Iadanza, A., Marelli, S., Cappa, S. F., Ferini‐Strambi, L., & Falini, A. (2014) · SLEEP · doi:10.5665/sleep.3994 · Cited by 221 · see citing works
Self-citation
Sleep disorders in aging and dementia
Bombois, S., Derambure, P., Pasquier, F., & Monaca, C. C. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0052-7 · Cited by 217 · see citing works
Executive Dysfunction in OSA Before and After Treatment: A Meta-Analysis
Olaithe, M., & Bucks, R. S. (2013) · SLEEP · doi:10.5665/sleep.2950 · Cited by 211 · see citing works
Associations Between Sleep Architecture and Sleep‐Disordered Breathing and Cognition in Older Community‐Dwelling Men: The Osteoporotic Fractures in Men Sleep Study
BLACKWELL, T. L., Yaffe, K. S., Ancoli‐Israel, S., Redline, S. S., Ensrud, K. E., Stefanick, M. L., Laffan, A. M., Stone, K. L., & for the Osteoporotic Fractures in Men Study Group (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03731.x · Cited by 207 · see citing works
Co-Morbidity, Mortality, Quality of Life and the Healthcare/Welfare/Social Costs of Disordered Sleep: A Rapid Review
Garbarino, S., Lanteri, P., Durando, P., Magnavita, N., & Sannita, W. G. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13080831 · Cited by 202 · see citing works
Improved memory function 12 weeks after bariatric surgery
Gunstad, J., Strain, G., Devlin, M. J., Wing, R., Cohen, R. A., Paul, R. H., Crosby, R. D., & Mitchell, J. E. (2011) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2010.09.015 · Cited by 185 · see citing works
Cognitive Function and Decline in Obesity
Stanek, K. M., & Gunstad, J. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111073 · Cited by 178 · see citing works
Cognitive Function After Bariatric Surgery: Evidence for Improvement 3 Years After Surgery
Alosco, M. L., Galioto, R., Spitznagel, M. B., Strain, G., Devlin, M., Cohen, R., Crosby, R. D., Mitchell, J. E., & Gunstad, J. (2014) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2013.05.018 · Cited by 172 · see citing works
Validation of the Mayo Sleep Questionnaire to Screen for REM Sleep Behavior Disorder in a Community-Based Sample
Boeve, B. F., Molano, J. R. V., Ferman, T. J., Lin, S.-C., Bieniek, K. F., Tippmann‐Peikert, M., Boot, B. P., Louis, E. K. S., Knopman, D. S., Petersen, R. C., et al. (2013) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.2670 · Cited by 166 · see citing works
Neuroimaging Insights into the Pathophysiology of Sleep Disorders
Desseilles, M., Dang‐Vu, T. T., Schabus, M., Virginie Sterpenich, A., Maquet, P., & Schwartz, S. (2008) · SLEEP · doi:10.1093/sleep/31.6.777 · Cited by 164 · see citing works
Reviewing the relationship between OSA and cognition: W here do we go from here?
Bucks, R. S., Olaithe, M., Rosenzweig, I., & Morrell, M. J. (2017) · Respirology · doi:10.1111/resp.13140 · Cited by 164 · see citing works
Cognitive complaints in obstructive sleep apnea
Vaessen, T. J. A., Overeem, S., & Sitskoorn, M. M. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.03.008 · Cited by 157 · see citing works
Sleep-disordered breathing and the risk of Alzheimer's disease
Liguori, C., Maestri, M., Spanetta, M., Placidi, F., Bonanni, E., Mercuri, N. B., & Guarnieri, B. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101375 · Cited by 150 · see citing works
The Cognitive Effects of Obstructive Sleep Apnea: An Updated Meta-analysis
Stranks, E. K., & Crowe, S. F. (2016) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acv087 · Cited by 151 · see citing works
A review of executive functions in obstructive sleep apnea syndrome
Saunamäki, T., & Jehkonen, M. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00744.x · Cited by 150 · see citing works
Sleep Disordered Breathing and Depression among U.S. Adults: National Health and Nutrition Examination Survey, 2005-2008
Wheaton, A. G., Perry, G. S., Chapman, D. P., & Croft, J. B. (2012) · SLEEP · doi:10.5665/sleep.1724 · Cited by 149 · see citing works
Sleep Disorders in Patients with Traumatic Brain Injury
Castriotta, R. J., & Murthy, J. N. (2010) · CNS Drugs · doi:10.2165/11584870-000000000-00000 · Cited by 148 · see citing works
Strategies to improve anxiety and depression in patients with COPD: a mental health perspective
Tselebis, A., Pachi, A., Ilias, Ι., Kosmas, E., Moussas, G., Tzanakis, Ν., & Bratis, D. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s79354 · Cited by 152 · see citing works
Cognitive Function and Sleep Related Breathing Disorders in a Healthy Elderly Population: the Synapse Study
Sforza, E. A., Roche, F., Thomas-Antérion, C., Kerleroux, J., Beauchet, O., Celle, S., Maudoux, D., Pichot, V., Laurent, B., & Barthélemy, J. (2010) · SLEEP · doi:10.1093/sleep/33.4.515 · Cited by 144 · see citing works
A Review of Neuroimaging in Obstructive Sleep Apnea
Zimmerman, M. E., & Aloia, M. S. (2006) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26665 · Cited by 143 · see citing works
Self-citation
Effect of oral appliance therapy on neurobehavioral functioning in obstructive sleep apnea: a randomized controlled trial
Naismith, S. L., Winter, V. R., Hickie, I. B., & Cistulli, P. A. (2005) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26365 · Cited by 140 · see citing works
Neurocognitive effects of obstructive sleep apnea syndrome
Verstraeten, E. (2007) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-007-0012-8 · Cited by 139 · see citing works
SleepSense: A Noncontact and Cost-Effective Sleep Monitoring System
Lin, F., Zhuang, Y., Song, C. L., Wang, A., Li, Y., Gu, C., Li, C., & Xu, W. (2016) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2016.2541680 · Cited by 138 · see citing works
Sleep Apnea Syndrome and Cognition
Sforza, E. A., & Roche, F. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00087 · Cited by 136 · see citing works
Sleep apnea in the elderly: A specific entity?
Launois, S. H., Pépin, J., & Levy, P. A. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2006.08.005 · Cited by 137 · see citing works
Cognitive Impairment in Patients With Traumatic Brain Injury and Obstructive Sleep Apnea
Wilde, M. C., Castriotta, R. J., Lai, J. M., Atanasov, S., Masel, B. E., & Kuna, S. T. (2007) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2007.07.012 · Cited by 133 · see citing works
A review of neurocognitive function and obstructive sleep apnea with or without daytime sleepiness
Zhou, J., Camacho, M., Tang, X., & Kushida, C. A. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.02.008 · Cited by 126 · see citing works
Improved memory function two years after bariatric surgery
Alosco, M. L., Spitznagel, M. B., Strain, G. W., Devlin, M. J., Cohen, R. A., Paul, R. H., Crosby, R. D., Mitchell, J. E., & Gunstad, J. (2013) · Obesity · doi:10.1002/oby.20494 · Cited by 123 · see citing works
Altered Resting-State Brain Activity in Obstructive Sleep Apnea
Zhang, Q., Wang, D., Qin, W., Li, Q., Chen, B.-Y., Zhang, Y., & Yu, C. (2013) · SLEEP · doi:10.5665/sleep.2620 · Cited by 120 · see citing works
Intermittent hypoxia: a low-risk research tool with therapeutic value in humans
Mateika, J. H., El‐Chami, M., Shaheen, D., & Ivers, B. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00564.2014 · Cited by 118 · see citing works
Brain Activation Changes Before and After PAP Treatment in Obstructive Sleep Apnea
Castronovo, V., Canessa, N., Ferini‐Strambi, L., Aloia, M. S., Consonni, M., Marelli, S., Iadanza, A., Bruschi, A., Falini, A., & Cappa, S. F. (2009) · SLEEP · doi:10.1093/sleep/32.9.1161 · Cited by 116 · see citing works
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Obstructive Sleep Apnea is Related to Impaired Cognitive and Functional Status after Stroke
Aaronson, J. A., van Bennekom, C. A. M., Hofman, W. F., van Bezeij, T., van den Aardweg, J. G., Groet, E., Kylstra, W. A., & Schmand, B. A. (2015) · SLEEP · doi:10.5665/sleep.4984 · Cited by 119 · see citing works
Role of Oxidative Stress in the Neurocognitive Dysfunction of Obstructive Sleep Apnea Syndrome
Zhou, L. Q., Chen, P., Peng, Y., & Ouyang, R. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9626831 · Cited by 112 · see citing works
Neuropsychological functioning after CPAP treatment in obstructive sleep apnea: A meta-analysis
Kylstra, W. A., Aaronson, J. A., Hofman, W. F., & Schmand, B. A. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.09.002 · Cited by 109 · see citing works
Mapping Gray Matter Reductions in Obstructive Sleep Apnea: An Activation Likelihood Estimation Meta-Analysis
Weng, H., Tsai, Y., Chen, C., Lin, Y., Yang, C., Tsai, Y., & Yang, C. (2014) · SLEEP · doi:10.5665/sleep.3330 · Cited by 104 · see citing works
Persistent sleepiness in CPAP treated obstructive sleep apnea patients: Evaluation and treatment
Santamaría, J., Iranzo, Á., Montserrat, J. M., & de Pablo, J. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.02.005 · Cited by 105 · see citing works
Obstructive sleep apnea-hypopnea syndrome: Etiology and diagnosis
Sankri-Tarbichi, A. G. (2012) · Avicenna Journal of Medicine · doi:10.4103/2231-0770.94803 · Cited by 103 · see citing works
Treatment of Sleep Disorders after Traumatic Brain Injury
Castriotta, R. J., Atanasov, S., Wilde, M. C., Masel, B. E., Lai, J. M., & Kuna, S. T. (2009) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27442 · Cited by 102 · see citing works
Cognitive deficits in adults with obstructive sleep apnea compared to children and adolescents
Krysta, K., Bratek, A., Zawada, K., & Stepańczak, R. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-015-1501-6 · Cited by 101 · see citing works
Sleep-Disordered Breathing in Neurodegenerative Diseases
Gaig, C., & Iranzo, Á. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-011-0248-1 · Cited by 101 · see citing works
Morbidities associated with obstructive sleep apnea
Vijayan, V. K. (2012) · Expert Review of Respiratory Medicine · doi:10.1586/ers.12.44 · Cited by 101 · see citing works
Executive function in patients with obstructive sleep apnea treated with continuous positive airway pressure
Lau, E. Y. Y., Eskes, G. A., Morrison, D., Rajda, M., & Spurr, K. F. (2010) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617710000901 · Cited by 98 · see citing works
Sleep and Cognitive Function in Multiple Sclerosis
Braley, T. J., Kratz, A. L., Kaplish, N., & Chervin, R. D. (2016) · Sleep · doi:10.5665/sleep.6012 · Cited by 97 · see citing works
Treatment of Circadian Rhythm Sleep Disorders with Light
Chuah, L. Y., & Chee, M. W. (2008) · Annals of the Academy of Medicine, Singapore · doi:10.47102/annals-acadmedsg.v37n8p669 · Cited by 96 · see citing works
Neurocognitive Dysfunction Associated With Sleep Quality and Sleep Apnea in Patients With Mild Cognitive Impairment
Kim, S.-J., Lee, J. H., Lee, D. Y., Jhoo, J. H., & Woo, J. I. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181e9b976 · Cited by 93 · see citing works
Adherence, Reports of Benefits, and Depression Among Patients Treated With Continuous Positive Airway Pressure
Wells, R. D., Freedland, K. E., Carney, R. M., Duntley, S. P., & Stepanski, E. J. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318068b2f7 · Cited by 92 · see citing works
Proton Magnetic Resonance Spectroscopy Study of Brain Metabolism in Obstructive Sleep Apnoea Syndrome before and after Continuous Positive Airway Pressure Treatment
Tonon, C., Vetrugno, R., Lodi, R., Gallassi, R., Provini, F., Iotti, S., Plazzi, G., Montagna, P., Lugaresi, E., & Barbiroli, B. (2007) · SLEEP · doi:10.1093/sleep/30.3.305 · Cited by 91 · see citing works
Obstructive Sleep Apnea in Neurodegenerative Disorders: Current Evidence in Support of Benefit from Sleep Apnea Treatment
Lajoie, A. C., Lafontaine, A., Kimoff, R. J., & Kamińska, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020297 · Cited by 88 · see citing works
Bariatric Surgery Patients Exhibit Improved Memory Function 12 Months Postoperatively
Miller, L. A., Crosby, R. D., Galioto, R., Strain, G. W., Devlin, M. J., Wing, R. R., Cohen, R. A., Paul, R. H., Mitchell, J. E., & Gunstad, J. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0970-7 · Cited by 88 · see citing works
The APOE ε4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea
Cosentino, F., Bosco, P., Drago, V., Prestianni, G., Lanuzza, B., Iero, I., Tripodi, M., Spada, R. S., Toscano, G., Caraci, F., et al. (2008) · Sleep Medicine · doi:10.1016/j.sleep.2007.10.015 · Cited by 83 · see citing works
Cognition in Obstructive Sleep Apnea-Hypopnea Syndrome (OSAS): Current Clinical Knowledge and the Impact of Treatment
Kielb, S., Ancoli‐Israel, S., Rebok, G. W., & Spira, A. P. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8182-1 · Cited by 83 · see citing works
Neurobehavioral effects of obstructive sleep apnea: an overview and heuristic model
Beebe, D. W. (2005) · Current Opinion in Pulmonary Medicine · doi:10.1097/01.mcp.0000183059.52924.39 · Cited by 82 · see citing works
Sleep-Disordered Breathing and Cognition in Older Adults
Zimmerman, M. E., & Aloia, M. S. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0298-z · Cited by 81 · see citing works
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Executive functions and cognitive subprocesses in patients with obstructive sleep apnoea
Lis, S., Krieger, S., HENNIG, D., Röder, C. H., Kirsch, P., Seeger, W., Gallhofer, B., & Schulz, R. (2008) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00660.x · Cited by 78 · see citing works
Brief Behavioral Therapies Reduce Early Positive Airway Pressure Discontinuation Rates in Sleep Apnea Syndrome: Preliminary Findings
Aloia, M. S., Smith, K., Arnedt, J. T., Millman, R. P., Stanchina, M., Carlisle, C., Hecht, J., & Borrelli, B. (2007) · Behavioral Sleep Medicine · doi:10.1080/15402000701190549 · Cited by 74 · see citing works
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Effects of continuous positive airway pressure on cognitition and neuroimaging data in sleep apnea
Ferini‐Strambi, L., Marelli, S., Galbiati, A., & Castronovo, C. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.03.022 · Cited by 73 · see citing works
Executive dysfunction in children affected by obstructive sleep apnea syndrome: an observational study
Esposito, M., Antinolfi, Gallai, B., Parisi, L., Roccella, M., Marotta, R., Lavano, S. M., Mazzotta, G., Precenzano, F., & Carotenuto, M. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s47287 · Cited by 68 · see citing works
Obstructive Sleep Apnea in Older Adults
Norman, D., & Loredo, J. S. (2007) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2007.08.006 · Cited by 65 · see citing works
Sleep disorders affect cognitive function in adults: an overview of systematic reviews and meta-analyses
Kong, J., Zhou, L., Li, X., & Ren, Q. (2023) · Sleep and Biological Rhythms · doi:10.1007/s41105-022-00439-9 · Cited by 70 · see citing works
NREM sleep instability changes following rapid maxillary expansion in children with obstructive apnea sleep syndrome
Miano, S., Rizzoli, A., Evangelisti, M., Bruni, O., Ferri, R., Pagani, J., & Villa, M. P. (2008) · Sleep Medicine · doi:10.1016/j.sleep.2008.04.003 · Cited by 65 · see citing works
A functional MRI evaluation of frontal dysfunction in patients with severe obstructive sleep apnea
Zhang, X., Ma, L., Li, S.-W., Wang, Y., & Wang, L. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2010.08.015 · Cited by 64 · see citing works
Effect of Obstructive Sleep Apnea on Neurocognitive Performance
Seda, G., & Han, T. S. (2019) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2019.10.001 · Cited by 63 · see citing works
Cognitive impairment in obstructive sleep apnea syndrome: a descriptive review
Caporale, M., Palmeri, R., Corallo, F., Muscarà, N., Romeo, L., Bramanti, A., Marino, S., & Buono, V. L. (2020) · Sleep And Breathing · doi:10.1007/s11325-020-02084-3 · Cited by 61 · see citing works
Neurocognitive performance and behavior before and after treatment for sleep-disordered breathing in children
Kohler, M. J. (2010) · Nature and Science of Sleep · doi:10.2147/nss.s6934 · Cited by 61 · see citing works
A new EEG biomarker of neurobehavioural impairment and sleepiness in sleep apnea patients and controls during extended wakefulness
D'Rozario, A. L., Kim, J. W., WONG, K. K. H., Bartlett, D. J., Marshall, N. S., Dijk, D., Robinson, P. A., & Grunstein, R. R. (2013) · Clinical Neurophysiology · doi:10.1016/j.clinph.2013.02.022 · Cited by 60 · see citing works
Effects of Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea on Cognitive Functions: Evidence for a Common Nature
Andreou, G., Vlachos, F., & Makanikas, K. (2014) · Sleep Disorders · doi:10.1155/2014/768210 · Cited by 59 · see citing works
Understanding the role of psychopathology in bariatric surgery outcomes
Marek, R. J., Ben-Porath, Y., & Heinberg, L. (2016) · Obesity Reviews · doi:10.1111/obr.12356 · Cited by 58 · see citing works
The Interaction between Obstructive Sleep Apnea and Parkinson’s Disease: Possible Mechanisms and Implications for Cognitive Function
Kamińska, M., Lafontaine, A., & Kimoff, R. J. (2015) · Parkinson s Disease · doi:10.1155/2015/849472 · Cited by 57 · see citing works
Disturbed sleep and diabetes: A potential nexus of dementia risk
Holingue, C., Wennberg, A. M. V., Berger, S., Polotsky, V. Y., & Spira, A. P. (2018) · Metabolism · doi:10.1016/j.metabol.2018.01.021 · Cited by 57 · see citing works
The relationship between sleep and cognition in Parkinson's disease: A meta-analysis
Pushpanathan, M. E., Loftus, A. M., Thomas, M. G., Gasson, N., & Bucks, R. S. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.04.003 · Cited by 54 · see citing works
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Authors: ALOIA, M. S., ARNEDT, J. T., DAVIS, J. D., RIGGS, R. L., & BYRD, D.
Affiliations: Brown University (US)
ORCID: ALOIA, MARK S.
ARNEDT, J. TODD
DAVIS, JENNIFER D.
BYRD, DESIREE
Venue: Journal of the International Neuropsychological Society
Publisher: Cambridge University Press (CUP)
Published: 2004-09
Volume: 10
Issue: 5
Pages: 772-785
ISSN: 1355-6177 (ISSN-L)
1469-7661
DOI: 10.1017/s1355617704105134
OpenAlex: W2030284843
Cited by: 391
References: 85
Citations by year: 2026: 5 · 2025: 12 · 2024: 2 · 2023: 18 · 2022: 16 · 2021: 25 · 2020: 17 · 2019: 11 · 2018: 20 · 2017: 24 · 2016: 39 · 2015: 15 · 2014: 25 · 2013: 34 · 2012: 28
FWCI: 1.09
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Journal of the International Neuropsychological Society (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL067209, R01 HL67209)
Topics: Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: obstructive sleep apnea-hypopnea syndrome, cognitive impairment, neuropsychological sequelae, attention and vigilance, excessive daytime sleepiness, hypoxemia, sleep fragmentation, depression, constructional ability
MeSH terms: Attention, Cognition, Cognition Disorders, Diagnosis, Differential, Humans, Intelligence, Language, Memory, Neuropsychological Tests, Problem Solving, Psychomotor Performance, MEDLINE, Sleep Apnea, Obstructive

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Neuropsychological sequelae of obstructive sleep apnea-hypopnea syndrome: a critical review

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