The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.
Effect of Interferon-α on cognitive functioning in patients with chronic hepatitis C
Abstract
Treatment with interferon-alpha (IFN-α) has been shown to adversely affect cognitive functioning in patients with a variety of medical disorders, but information about the effects of IFN-α on cognitive functioning in patients with chronic hepatitis C (CHC) is limited. The purpose of this study was to examine the effects of IFN-α on neuropsychological test performance in CHC patients. Participants were 30 patients with CHC, 11 who underwent IFN-α therapy and 19 who did not. All participants were tested at baseline (i.e., pretreatment) and approximately 6 months later with the Symbol Digit Modalities Test and Trail Making Test. Results revealed that the treatment group performed significantly worse than untreated CHC patients on Part B of the Trail Making Test after approximately 6 months of treatment. No significant group differences were found on Part A of the Trail Making Test or Symbol Digit Modalities Test. Findings suggest that CHC patients undergoing treatment with IFN-α may experience reduced abilities to benefit from practice but suffer no decrements in performance after 6 months of treatment. Additional research is needed to replicate these findings and to explore risk factors for susceptibility to IFN-α-induced effects. (JINS, 2005,11, 16–22.)
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“hepatitis C patients who received 6 months of IFN-α performed significantly worse on the TMT part B when compared with hepatitis C patients who did not undergo IFN-α treatment (Hilsabeck et al., 2005)”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Hilsabeck et al., 2005
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Metadata
- Authors
- HILSABECK, R. C., HASSANEIN, T. I., ZIEGLER, E. A., CARLSON, M. D., & PERRY, W.
- Affiliations
- Texas Tech University (US)
- University of California San Diego (US)
- Venue
- Journal of the International Neuropsychological Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2005-01
- Volume
- 11
- Issue
- 1
- Pages
- 16-22
- ISSN
- 1355-6177 (ISSN-L)
- 1469-7661
- OpenAlex
- W2150327179
- Cited by
- 40
- References
- 55
- Citations by year
- 2022: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the International Neuropsychological Society (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- interferon-alpha, chronic hepatitis C, cognitive function, neuropsychological performance, Trail Making Test, Symbol Digit Modalities Test, practice effects, antiviral therapy adverse effects
- MeSH terms
- Antiviral Agents, Cognition Disorders, Female, Hepatitis C, Humans, Immunologic Factors, Male, Middle Aged, Neuropsychological Tests, Psychomotor Performance, Treatment Outcome, Interferon-alpha
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