IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C
Open accessAbstract
Interferon (IFN)-alpha has been used to investigate pathways by which innate immune cytokines influence the brain and behaviour. Previous studies suggest that altered basal ganglia function may contribute to IFN-alpha-induced neuropsychological and behavioural changes. To further examine IFN-alpha effects on neuropsychological functions related to basal ganglia (as well as other brain regions), and explore the relationship between altered neuropsychological function and IFN-alpha-induced depression and fatigue, a selected subset of the Cambridge Neuropsychological Test Automated Battery was administered to 32 hepatitis C patients at baseline (Visit 1) and following approximately 12 weeks (Visit 2) of either no treatment (n=12) or treatment with IFN-alpha plus ribavirin (n=20). Symptoms of depression and fatigue were assessed using the Montgomery-Asberg Depression Rating Scale and the Multidimensional Fatigue Inventory. Compared to control subjects, patients treated with IFN-alpha/ribavirin exhibited significant decreases in motor speed as measured in the simple and five-choice movement segments of the CANTAB reaction time task and slower response times in the rapid visual information processing task, a task of sustained attention. Decreased motor speed on the five-choice movement segments of the reaction time task was in turn correlated with increased symptoms of depression and fatigue (R=0.47, p<0.05 and R=0.48, p<0.05, respectively). IFN-alpha/ribavirin treatment had no effects on executive function, decision time in the reaction time task, or target detection accuracy in the sustained attention task. Motor slowing and its correlation with psychiatric symptoms suggest that altered basal ganglia function may contribute to the pathogenesis of IFN-alpha-induced behavioural changes.
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The only study examining inflammation and planning ability found no effect of IFN-α plus ribavirin on Stockings of Cambridge planning performance.
“This study used IFN-α (plus ribavirin) as an inflammatory stimulus and measured planning ability with the Stockings of Cambridge task, and no effect of inflammation on planning ability was observed (Majer et al., 2008).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Majer et al., 2008
IFN-α (plus ribavirin) therapy led to significant decreases in motor speed among patients with hepatitis C.
“IFN-α (plus ribavirin) therapy led to significant decreases in motor speed among patients with hepatitis C (Majer et al., 2008).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Majer et al., 2008
In that study, decreased motor speed was associated with increased symptoms of fatigue.
“Notably, decreased motor speed in this study was also associated with increased symptoms of depression and fatigue (Majer et al., 2008).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Majer et al., 2008
In that study, decreased motor speed was associated with increased symptoms of depression.
“Notably, decreased motor speed in this study was also associated with increased symptoms of depression and fatigue (Majer et al., 2008).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Majer et al., 2008
The fatigue of depression, often a residual symptom of SSRI therapy, is a prominent feature of cytokine-induced depression and may represent cytokine effects on basal ganglia and dopamine function.
“The fatigue of depression, which is often a residual symptom of SSRI therapy, is a prominent feature of cytokine-induced depression, and may represent cytokine effects on the basal ganglia and dopamine (DA) function (Capuron et al., 2001, Majer et al., 2008, Capuron et al., 2009).”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Majer et al., 2008
Depression and fatigue are the main side effects of treatment with interferon-alpha.
“depression and fatigue are the main side effects of treatment with IFN-α (111, 112).”
From Cytokine Research in Depression: Principles, Challenges, and Open Questions (2019) · cites this paper as [112]
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Immune system to brain signaling: Neuropsychopharmacological implications
Capuron, L., & Miller, A. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.014 · Cited by 1,195 · see citing works
Self-citationInflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works
Miller, A. H., Haroon, E., Raison, C. L., & Felger, J. C. (2013) · Depression and Anxiety · doi:10.1002/da.22084 · Cited by 892 · see citing works
Self-citationRaison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.116 · Cited by 630 · see citing works
Self-citationInflammation Effects on Motivation and Motor Activity: Role of Dopamine
Felger, J. C., & Treadway, M. T. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.143 · Cited by 453 · see citing works
Imaging the Role of Inflammation in Mood and Anxiety-related Disorders
Felger, J. C. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171123201142 · Cited by 432 · see citing works
Felger, J. C., & Miller, A. H. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.09.003 · Cited by 394 · see citing works
Self-citationCapuron, L., Pagnoni, G., Drake, D. F., Woolwine, B. J., Spivey, J. R., Crowe, R. J., Votaw, J. R., Goodman, M. M., & Miller, A. H. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2094 · Cited by 382 · see citing works
Self-citationRaison, C. L., Borisov, A. S., Majer, M., Drake, D. F., Pagnoni, G., Woolwine, B. J., Vogt, G. J., Massung, B., & Miller, A. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.010 · Cited by 367 · see citing works
Self-citationSalamone, J. D., Yohn, S. E., López-Cruz, L., San Miguel, N., & Correa, M. (2016) · Brain · doi:10.1093/brain/aww050 · Cited by 350 · see citing works
Cytokine Research in Depression: Principles, Challenges, and Open Questions
Himmerich, H., Patsalos, O., Lichtblau, N., Ibrahim, M. A. A., & Dalton, B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00030 · Cited by 313 · see citing works
Miller, A. H. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.08.006 · Cited by 261 · see citing works
Self-citationShelton, R. C., & Miller, A. H. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.004 · Cited by 257 · see citing works
Self-citationThe evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
Raison, C. L., & Miller, A. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.2 · Cited by 253 · see citing works
Self-citationHaroon, E., Fleischer, C. C., Felger, J. C., Chen, X., Woolwine, B. J., Patel, T., Hu, X. P., & Miller, A. H. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.206 · Cited by 250 · see citing works
Self-citationInflammation and the dimensions of depression: A review
Majd, M., Saunders, E. F. H., & Engeland, C. G. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100800 · Cited by 222 · see citing works
Inflammation-Related Functional and Structural Dysconnectivity as a Pathway to Psychopathology
Goldsmith, D. R., Bekhbat, M., Mehta, N. D., & Felger, J. C. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.11.003 · Cited by 220 · see citing works
Felger, J. C., Mun, J., Kimmel, H. L., Nye, J. A., Drake, D. F., Hernandez, C. R., Freeman, A. A., Rye, D. B., Goodman, M. M., Howell, L. L., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.115 · Cited by 214 · see citing works
Self-citationRaison, C. L., Borisov, A. S., Woolwine, B. J., Massung, B., Vogt, G., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.58 · Cited by 183 · see citing works
Self-citationTowards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms, and Future Directions
Miller, B. J., & Goldsmith, D. R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.211 · Cited by 182 · see citing works
Felger, J. C., Li, L., Marvar, P. J., Woolwine, B. J., Harrison, D. G., Raison, C. L., & Miller, A. H. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.010 · Cited by 176 · see citing works
Self-citationDooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176 · see citing works
Capuron, L., Fornwalt, F. B., Knight, B. T., Harvey, P. D., Ninan, P. T., & Miller, A. H. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.02.017 · Cited by 164 · see citing works
Self-citationMorris, G., Berk, M., Gałecki, P., Walder, K. R., & Maes, M. H. J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9090-9 · Cited by 160 · see citing works
Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation
Miller, A. H., Haroon, E., & Felger, J. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.167 · Cited by 152 · see citing works
Self-citationMechanisms by which sleep disturbance contributes to osteoarthritis pain: A conceptual model
Smith, M. T., Quartana, P. J., Okonkwo, R., & Nasir, A. (2009) · Current Pain and Headache Reports · doi:10.1007/s11916-009-0073-2 · Cited by 152 · see citing works
Goldsmith, D. R., Haroon, E., Woolwine, B. J., Jung, M. Y., Wommack, E. C., Harvey, P. D., Treadway, M. T., Felger, J. C., & Miller, A. H. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.03.025 · Cited by 142 · see citing works
Self-citationRaison, C. L., Rye, D. B., Woolwine, B. J., Vogt, G. J., Bautista, B. M., Spivey, J. R., & Miller, A. H. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.019 · Cited by 116 · see citing works
Self-citationMott, A. M., Nunes, E. J., Collins, L. E., Port, R. G., Sink, K. S., Hockemeyer, J., Müller, C. E., & Salamone, J. D. (2009) · Psychopharmacology · doi:10.1007/s00213-008-1441-z · Cited by 116 · see citing works
The role of dopamine in inflammation-associated depression: mechanisms and therapeutic implications
Felger, J. C. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_13 · Cited by 115 · see citing works
Lasselin, J., Lekander, M., Axelsson, J., & Karshikoff, B. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.06.005 · Cited by 106 · see citing works
Salamone, J. D., Farrar, A. M., Font, L., Patel, V. B., Schlar, D. E., Nunes, E. J., Collins, L. E., & Sager, T. N. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.02.021 · Cited by 105 · see citing works
Firth, J., Veronese, N., Cotter, J., Shivappa, N., Hébert, J. R., Ee, C., Smith, L., Stubbs, B., Jackson, S. E., & Sarris, J. J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00350 · Cited by 97 · see citing works
Yohn, S. E., Arif, Y., Haley, A., Tripodi, G., Baqi, Y., Müller, C. E., Miguel, N. S., Correa, M., & Salamone, J. D. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4392-9 · Cited by 93 · see citing works
Role of Inflammation in Depression and Treatment Implications
Felger, J. C. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_166 · Cited by 92 · see citing works
Nunes, E. J., Randall, P. A., Santerre, J. L., Given, A. M., Sager, T. N., Correa, M., & Salamone, J. D. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.068 · Cited by 91 · see citing works
Draper, A., Koch, R. M., van der Meer, J. W., Apps, M. A. J., Pickkers, P., Masud Husain, B., & van der Schaaf, M. E. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.231 · Cited by 91 · see citing works
Influences of dopaminergic system dysfunction on late-life depression
Taylor, W. D., Zald, D. H., Felger, J. C., Christman, S., Claassen, D. O., Horga, G., Miller, J. M., Gifford, K., Rogers, B., Szymkowicz, S. M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01265-0 · Cited by 89 · see citing works
Sarkar, S., Jiang, Z., Evon, D. M., Wahed, A. S., & Hoofnagle, J. H. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.06.030 · Cited by 83 · see citing works
In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease
Tournier, B. B., Tsartsalis, S., Ceyzériat, K., Garibotto, V., & Millet, P. (2020) · Cells · doi:10.3390/cells9091941 · Cited by 79 · see citing works
Worden, L. T., Shahriari, M., Farrar, A. M., Sink, K. S., Hockemeyer, J., Müller, C. E., & Salamone, J. D. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1396-0 · Cited by 79 · see citing works
Fatigue symptoms relate to systemic inflammation in patients with type 2 diabetes
Lasselin, J., Layé, S., Dexpert, S., Aubert, A., Gonzalez, C., Gin, H., & Capuron, L. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.03.003 · Cited by 77 · see citing works
Self-citationSekio, M., & Seki, K. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu005 · Cited by 75 · see citing works
Fatigue in inflammatory rheumatic disorders: pathophysiological mechanisms
Korte, S. M., & Straub, R. H. (2019) · Rheumatology · doi:10.1093/rheumatology/kez413 · Cited by 69 · see citing works
Raison, C. L., & Miller, A. H. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.194 · Cited by 68 · see citing works
Self-citationThe possible role of the kynurenine pathway in anhedonia in adolescents
Gabbay, V., Ely, B. A., Babb, J. S., & Liebes, L. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0685-7 · Cited by 66 · see citing works
Haroon, E., Felger, J. C., Woolwine, B. J., Chen, X., Parekh, S., Spivey, J. R., Hu, X. P., & Miller, A. H. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.12.004 · Cited by 63 · see citing works
Self-citationPérez‐Sánchez, G., Becerril‐Villanueva, E., Arreola, R., Martínez-Levy, G. A., Hernández, M. E., Velasco-Velázquez, M. A., Álvarez-Herrera, S., Cruz-Fuentes, C. S., Palacios, L., de la Peña, F., et al. (2018) · Mediators of Inflammation · doi:10.1155/2018/4074051 · Cited by 62 · see citing works
Neuronal Mitochondrial Dysfunction and Bioenergetic Failure in Inflammation-Associated Depression
Casaril, A. M., Dantzer, R., & Orth, C. B. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.725547 · Cited by 58 · see citing works
Felger, J. C., Cole, S. W., Pace, T. W. W., Hu, F., Woolwine, B. J., Doho, G., Raison, C. L., & Miller, A. H. (2011) · Psychological Medicine · doi:10.1017/s0033291711002868 · Cited by 56 · see citing works
Self-citationPalé, L. A., Caballero, J. L., Buxareu, B. S., Salgado, P., & Pérez, V. (2017) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2017.07.008 · Cited by 50 · see citing works
Arnett, S., & Clark, I. A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.04.004 · Cited by 49 · see citing works
Vichaya, E. G., & Dantzer, R. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.01.008 · Cited by 47 · see citing works
Huckans, M. S., Fuller, B. E., Wheaton, V. R., Jaehnert, S., Ellis, C. C., Kolessar, M., Kříž, D., Anderson, J. R., Berggren, K., Olavarria, H., et al. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.07.020 · Cited by 45 · see citing works
Piser, T. M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.02.006 · Cited by 44 · see citing works
Brick by Brick: Building a Transdiagnostic Understanding of Inflammation in Psychiatry
Thylur, D. S., & Goldsmith, D. R. (2022) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000326 · Cited by 40 · see citing works
Managing systemic symptoms in chronic liver disease
Newton, J. L., & Jones, D. E. J. (2012) · Journal of Hepatology · doi:10.1016/s0168-8278(12)60006-3 · Cited by 40 · see citing works
Salamone, J. D., Correa, M., Farrar, A. M., Nunes, E. J., & Collins, L. E. (2010) · Future Neurology · doi:10.2217/fnl.10.19 · Cited by 40 · see citing works
Can we vaccinate against depression?
Rook, G. A. W., Raison, C. L., & Lowry, C. A. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.03.018 · Cited by 39 · see citing works
Self-citationIntegrating the monoamine and cytokine hypotheses of depression: Is histamine the missing link?
Hersey, M., Hashemi, P., & Reagan, L. P. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15392 · Cited by 37 · see citing works
Rance, J., Newland, J., Hopwood, M., & Treloar, C. (2011) · Social Science & Medicine · doi:10.1016/j.socscimed.2011.10.003 · Cited by 37 · see citing works
Risk factors for the development of depression in patients with hepatitis C taking interferon-α
Smith, K. J. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s13917 · Cited by 35 · see citing works
Salamone, J. D., Correa, M., Yohn, S. E., Yang, J.-H., Somerville, M., Rotolo, R. A., & Presby, R. E. (2017) · Motivation Science · doi:10.1037/mot0000070 · Cited by 35 · see citing works
Bekhbat, M., Goldsmith, D. R., Woolwine, B. J., Haroon, E., Miller, A. H., & Felger, J. C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01258-z · Cited by 33 · see citing works
Self-citationDopamine, effort, and decision making: Theoretical comment on Bardgett et al. (2009).
Salamone, J. D. (2009) · Behavioral Neuroscience · doi:10.1037/a0015381 · Cited by 31 · see citing works
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Lebeña, A., Vegas, Ó., Gómez-Lázaro, E., Arregi, A., Garmendia, L., Beitia, G., & Azpiroz, A. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.045 · Cited by 30 · see citing works
Mental Quality of Life Is Related to a Cytokine Genetic Pathway
Schoormans, D., Radonic, T. R., de Witte, P., Groenink, M., Azim, D., Lutter, R., Mulder, B. J. M., Sprangers, M. A. G., & Zwinderman, A. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045126 · Cited by 29 · see citing works
Aging as a Context for the Role of Inflammation in Depressive Symptoms
Straka, K., Tran, M.-L. M., Millwood, S. N., Swanson, J., & Kuhlman, K. R. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.605347 · Cited by 25 · see citing works
Dopamine Transmission Imbalance in Neuroinflammation: Perspectives on Long-Term COVID-19
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Cognitive function and endogenous cytokine levels in children with chronic hepatitis C
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Cognitive impairments in HCV infection: From pathogenesis to neuroimaging
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Multidimensional Fatigue Inventory in People With Hepatitis B Infection
Saffari, M., Naderi, M. K., Piper, C. N., & Koenig, H. G. (2017) · Gastroenterology Nursing · doi:10.1097/sga.0000000000000250 · Cited by 17 · see citing works
Cytokines as Neuromodulators: Insights From Experimental Studies With Humans and Nonhuman Primates
Martins, D., & Harrison, N. A. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.06.037 · Cited by 14 · see citing works
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Zervides, K. A., Grenmyr, E., Janelidze, S., Linge, P., Nystedt, J., Nilsson, P. C., Sundgren, P. C., Hansson, O., Bengtsson, A. A., & Jönsen, A. (2025) · Arthritis Research & Therapy · doi:10.1186/s13075-025-03539-2 · Cited by 13 · see citing works
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The Role of Attachment Style and Depression in Patients with Hepatitis C
Sockalingam, S., Blank, D., Jarad, A. A., Alosaimi, F. D., Hirschfield, G. M., & Abbey, S. E. (2012) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-012-9335-y · Cited by 12 · see citing works
Neurocognitive Performance in Depressed Patients with low-grade inflammation and somatic symptoms
Kaşer, M., Foley, É. M., & Khandaker, G. M. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100409 · Cited by 12 · see citing works
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Lipopolysaccharide Effects on Neurotransmission: Understanding Implications for Depression
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Wang, M., Yu, X., & Gao, Q. (2024) · Current Medical Science · doi:10.1007/s11596-024-2859-1 · Cited by 8 · see citing works
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The Role of Immune System in Depression Disorder
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Inflammatory stress responses and future mental health outcomes in people with type 2 diabetes
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Vaccination and Immunotherapy for Major Depression
Evrensel, A., Ünsalver, B. Ö., Ceylan, M. E., & Tarhan, N. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6044-0_25 · Cited by 5 · see citing works
- Authors
- Majer, M., Welberg, L. A. M., Capuron, L., Pagnoni, G., Raison, C. L., & Miller, A. H.
- Affiliations
- Emory University (US)
- Corresponding author
- Miller, Andrew H.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 22
- Issue
- 6
- Pages
- 870-880
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC2497339
- OpenAlex
- W2058231748
- Cited by
- 124
- References
- 93
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 11 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 13 · 2015: 4 · 2014: 7 · 2013: 4 · 2012: 16
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (UL1TR000454)
- National Heart, Lung, and Blood Institute (R01HL073921)
- National Institute of Mental Health (R01MH067990, K05MH069124)
- National Center for Research Resources (MO-1-RR-00039, M01RR000039)
- NIH Clinical Center
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- interferon-alpha, chronic hepatitis C, motor slowing, depression, fatigue, basal ganglia, neuropsychological outcomes, ribavirin, reaction time, sustained attention
- MeSH terms
- Adult, Antiviral Agents, Basal Ganglia, Depression, Fatigue, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Psychiatric Status Rating Scales, Reaction Time, Regression Analysis, Ribavirin, Interferon-alpha, Hepatitis C, Chronic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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