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Cited by 40Hepatitis C virus researchCancer-related cognitive impairment studiesSchizophrenia research and treatment

The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.

Effect of Interferon-α on cognitive functioning in patients with chronic hepatitis C

HILSABECK, ROBIN C., HASSANEIN, TAREK I., ZIEGLER, ELIZABETH A., CARLSON, MEGHAN D., PERRY, WILLIAM·2005·Journal of the International Neuropsychological Society
DOI 10.1017/s1355617705050022
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Abstract

Treatment with interferon-alpha (IFN-α) has been shown to adversely affect cognitive functioning in patients with a variety of medical disorders, but information about the effects of IFN-α on cognitive functioning in patients with chronic hepatitis C (CHC) is limited. The purpose of this study was to examine the effects of IFN-α on neuropsychological test performance in CHC patients. Participants were 30 patients with CHC, 11 who underwent IFN-α therapy and 19 who did not. All participants were tested at baseline (i.e., pretreatment) and approximately 6 months later with the Symbol Digit Modalities Test and Trail Making Test. Results revealed that the treatment group performed significantly worse than untreated CHC patients on Part B of the Trail Making Test after approximately 6 months of treatment. No significant group differences were found on Part A of the Trail Making Test or Symbol Digit Modalities Test. Findings suggest that CHC patients undergoing treatment with IFN-α may experience reduced abilities to benefit from practice but suffer no decrements in performance after 6 months of treatment. Additional research is needed to replicate these findings and to explore risk factors for susceptibility to IFN-α-induced effects. (JINS, 2005,11, 16–22.)

Overview

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Registry

Crossref · 10.1017/s1355617705050022

Cites

54 of 54 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 3

  1. de Boer, A.G. & Breimer, D.D. (1998).Cytokines and blood-brain barrier permeability. In H.S. Sharma & J. Westman (Eds.),Progress in brain research, volume 115 (pp.425–451).New York:Elsevier Science.
  2. Lezak, M.D. (1995).Neuropsychological Assessment(3rd ed.).New York:Oxford University Press.
  3. Beck, A.T. , Steer, R.A. , & Brown, G.K. (1996).Beck Depression Inventory–Second Edition: Manual.San Antonio, TX:The Psychological Corporation.

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Metadata

Authors
HILSABECK, R. C., HASSANEIN, T. I., ZIEGLER, E. A., CARLSON, M. D., & PERRY, W.
Affiliations
  • Texas Tech University (US)
  • University of California San Diego (US)
ORCID
Venue
Journal of the International Neuropsychological Society
Publisher
Cambridge University Press (CUP)
Published
2005-01
Volume
11
Issue
1
Pages
16-22
ISSN
  • 1355-6177 (ISSN-L)
  • 1469-7661
DOI
10.1017/s1355617705050022
OpenAlex
W2150327179
Cited by
40
References
55
Citations by year
2022: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 2
FWCI
3.09
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 27 d)
Locations
  • Journal of the International Neuropsychological Society (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
interferon-alpha, chronic hepatitis C, cognitive function, neuropsychological performance, Trail Making Test, Symbol Digit Modalities Test, practice effects, antiviral therapy adverse effects
MeSH terms
Antiviral Agents, Cognition Disorders, Female, Hepatitis C, Humans, Immunologic Factors, Male, Middle Aged, Neuropsychological Tests, Psychomotor Performance, Treatment Outcome, Interferon-alpha

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