Substantial risk of “Accidental MCI” in healthy older adults: Base rates of low memory scores in neuropsychological assessment
Abstract
When assessing older adults for mild cognitive impairment (MCI) or dementia, it is important to understand how often low memory scores are obtained in healthy people in order to minimize false positive diagnoses. This study examines the base rates of low memory scores in older adults across a battery of memory tests. Participants included older adults (55–79 years; N = 742) from the Neuropsychological Assessment Battery (NAB; Stern & White, 2003a) standardization sample. The NAB Memory Module consists of four co-normed memory tests (i.e., List Learning, Shape Learning, Story Learning, and Daily Living Memory) yielding 10 demographically corrected T-scores. When all 10 T-scores were examined simultaneously, 55.5% of older adults had one or more scores one standard deviation (SD) below the mean. At <1.5 SDs, 30.8% of healthy older adults obtained one or more low memory scores. Obtaining low memory scores occurs more often with lesser intellectual abilities. For example, 56.5% of older adults with low average intellectual abilities obtained one or more low memory scores (<1.5 SDs) compared to 21.1% with high average intellectual abilities. Understanding the base rates of low scores can reduce over-interpretation of isolated low memory scores and minimize false positive diagnoses of MCI. (JINS, 2007, 13, 490–500.)The data in Tables 3, 4, 5, 6, and 7 are original data produced by special permission of the Publisher, Psychological Assessment Resources, Inc., 16204 North Florida Avenue, Lutz, Florida 33549, from the standardization data presented in the Neuropsychological Assessment Battery Psychometric and Technical Manual by Travis White, Ph.D. and Robert A. Stern, Ph.D. Copyright 2001, 2003 by PAR, Inc. Further reproduction is prohibited without permission from PAR, Inc.
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Brooks et al. showed that 26% of the older adults in the standardization sample for the WMS-III obtained one or more age-adjusted standard score that was more than 1.5 SDs below the mean.
“Brooks et al. [42] showed that 26% of the older adults in the standardization sample for the WMS-III [43] obtained one or more age-adjusted standard score that was more than 1.5 SDs below the mean.”
From Neuropsychological Criteria for Mild Cognitive Impairment Improves Diagnostic Precision, Biomarker Associations, and Progression Rates (2014) · cites this paper as [42]
Cites
Base Rates of “Impaired” Neuropsychological Test Performance Among Healthy Older Adults
Palmer, B. (1998) · Archives of Clinical Neuropsychology · doi:10.1016/s0887-6177(97)00037-1 · Cited by 142 · see citing works
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Bondi, M. W., Initiative, F. T. A. D. N., Edmonds, E. C., Jak, A. J., Clark, L. R., Delano-Wood, L., McDonald, C. R., Nation, D. A., Libon, D. J., Au, R., et al. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-140276 · Cited by 750 · see citing works
Edmonds, E. C., Delano‐Wood, L., Clark, L. R., Jak, A. J., Nation, D. A., McDonald, C. R., Libon, D. J., Au, R., Galasko, D., Salmon, D. P., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.03.005 · Cited by 256 · see citing works
Subjective Cognitive Complaints Contribute to Misdiagnosis of Mild Cognitive Impairment
Edmonds, E. C., Delano-Wood, L., Galasko, D. R., Salmon, D. P., & Bondi, M. W. (2014) · Journal of the International Neuropsychological Society · doi:10.1017/s135561771400068x · Cited by 249 · see citing works
Brooks, B. L., Sherman, E. M. S., & Iverson, G. L. (2010) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acq005 · Cited by 61 · see citing works
Self-citationHealthy children and adolescents obtain some low scores across a battery of memory tests
BROOKS, B. L., IVERSON, G. L., SHERMAN, E. M. S., & HOLDNACK, J. A. (2009) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617709090651 · Cited by 50 · see citing works
Self-citation
- Authors
- BROOKS, B. L., IVERSON, G. L., & WHITE, T.
- Affiliations
- Riverview Hospital (CA)
- University of British Columbia (CA)
- Venue
- Journal of the International Neuropsychological Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007-03-20
- Volume
- 13
- Issue
- 03
- Pages
- 490-500
- ISSN
- 1355-6177 (ISSN-L)
- 1469-7661
- OpenAlex
- W2157269757
- Cited by
- 140
- References
- 1
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 7 · 2022: 5 · 2021: 10 · 2020: 9 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 8 · 2015: 5 · 2014: 13 · 2013: 5 · 2012: 5
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the International Neuropsychological Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Academy of Neurology
- Johns Hopkins University
- National Academy of Neuropsychology
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- mild cognitive impairment, false-positive diagnosis, base rates, healthy older adults, neuropsychological test battery, memory tests, dementia screening, standardization sample
- MeSH terms
- Aged, Cognition Disorders, Female, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Risk, Statistics as Topic, Geriatric Assessment
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