D-KEFS trail making test performance in patients with lateral prefrontal cortex lesions
Abstract
This study evaluated cognitive set-shifting in 12 patients with focal lesions in the lateral prefrontal cortex (LPC) by examining their performance on the Trail Making Test from the Delis-Kaplan Executive Function System (D-KEFS). Patients with LPC lesions performed significantly worse than controls on the D-KEFS Trail Making Test on the Letter Sequencing, Number-Letter Switching (set-shifting), and Motor Speed conditions. Patients with LPC lesions performed significantly more slowly on the Number-Letter Switching condition even after controlling for performance on the four baseline conditions of the test. In addition, patients with LPC lesions exhibited significantly elevated error rates on the Number-Letter Switching condition. Results suggest that LPC lesions can lead to impaired cognitive set-shifting on a visual-motor sequencing task. (JINS, 2007, 13, 704–709.)
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The paradox of cognitive flexibility in autism
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- Authors
- YOCHIM, B., BALDO, J., NELSON, A., & DELIS, D. C.
- Affiliations
- University of Colorado Colorado Springs (US)
- VA Northern California Health Care System (US)
- University of California San Diego (US)
- Venue
- Journal of the International Neuropsychological Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007-05-18
- Volume
- 13
- Issue
- 4
- Pages
- 704-709
- ISSN
- 1355-6177 (ISSN-L)
- 1469-7661
- OpenAlex
- W1966774731
- Cited by
- 97
- References
- 20
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 2 · 2015: 13 · 2014: 4 · 2013: 6 · 2012: 9
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the International Neuropsychological Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS17778)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- Trail Making Test, Delis-Kaplan Executive Function System, executive function, motor speed, error rate, brain injury
- MeSH terms
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Brain Injuries, Brain Mapping, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Photic Stimulation, Problem Solving, Reaction Time, Tomography, X-Ray Computed, Trail Making Test, Prefrontal Cortex
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