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Cited by 242Traumatic Brain Injury ResearchAdvanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity Studies

Traumatic brain injury as a disorder of brain connectivity

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Hayes, Jasmeet P., Bigler, Erin D., Verfaellie, Mieke·2016·Journal of the International Neuropsychological Society
DOI 10.1017/s1355617715000740PMC PMC5734864
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Abstract

Objectives: Recent advances in neuroimaging methodologies sensitive to axonal injury have made it possible to assess in vivo the extent of traumatic brain injury (TBI) -related disruption in neural structures and their connections. The objective of this paper is to review studies examining connectivity in TBI with an emphasis on structural and functional MRI methods that have proven to be valuable in uncovering neural abnormalities associated with this condition. Methods: We review studies that have examined white matter integrity in TBI of varying etiology and levels of severity, and consider how findings at different times post-injury may inform underlying mechanisms of post-injury progression and recovery. Moreover, in light of recent advances in neuroimaging methods to study the functional connectivity among brain regions that form integrated networks, we review TBI studies that use resting-state functional connectivity MRI methodology to examine neural networks disrupted by putative axonal injury. Results: The findings suggest that TBI is associated with altered structural and functional connectivity, characterized by decreased integrity of white matter pathways and imbalance and inefficiency of functional networks. These structural and functional alterations are often associated with neurocognitive dysfunction and poor functional outcomes. Conclusions: TBI has a negative impact on distributed brain networks that lead to behavioral disturbance. ( JINS , 2016, 22 , 120–137)

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  • Damage to densely connected and cognitively relevant regions such as the frontal lobes contributes to reduced efficiency of functional networks relevant to cognition.

    “Specifically, damage to regions that are densely anatomically connected and cognitively relevant, such as the frontal lobes (McDonald, Flashman, & Saykin, 2002), contributes to reduced efficiency of functional networks relevant to cognition (Hayes et al., 2016).”

    From Investigation of neurobiological responses to theta burst stimulation during recovery from mild traumatic brain injury (mTBI) (2023) · cites this paper as Hayes et al., 2016

  • Dysregulated connectivity is associated with higher self-reported symptoms and poorer cognitive performance, leading mTBI to be conceptualized as a disorder of brain connectivity and a disconnection syndrome.

    “Associations have been reported between dysregulated connectivity, higher levels of self-reported symptoms and poorer cognitive performance, leading mTBI to be conceptualized as a “disorder of brain connectivity” (Hayes, Bigler, & Verfaellie, 2016) and a “disconnection syndrome” (Coyle, Ponsford, & Hoy, 2018).”

    From Investigation of neurobiological responses to theta burst stimulation during recovery from mild traumatic brain injury (mTBI) (2023) · cites this paper as Hayes, Bigler, & Verfaellie, 2016

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  1. Adams JH Doyle D Ford I Gennarelli TA Graham DI McLellan DR 1989 Diffuse axonal injury in head injury: Definition, diagnosis and grading Histopathology 15 49 59 2767623
  2. Arenivas A Diaz-Arrastia R Spence J Cullum C Krishnan K Bosworth C Marquez de la Plata C 2014 Three approaches to investigating functional compromise to the default mode network after traumatic axonal injury Brain Imaging and Behavior 8 407 419 22847713
  3. Arfanakis K Haughton VM Carew JD Rogers BP Dempsey RJ Meyerand ME 2002 Diffusion tensor MR imaging in diffuse axonal injury AJNR: American Journal of Neuroradiology 23 794 802 12006280 PMC7974716
  4. Arnemann KL Chen AJW Novakovic-Agopian T Gratton C Nomura EM D’Esposito M 2015 Functional brain network modularity predicts response to cognitive training after brain injury Neurology 84 1568 1574 25788557 PMC4408280
  5. Ashwal S Tong KA Ghosh N Bartnik-Olson B Holshouser BA 2014 Application of advanced neuroimaging modalities in pediatric traumatic brain injury Journal of Child Neurology 29 1704 1717 24958007 PMC4388155
  6. Bazarian JJ Donnelly K Peterson DR Warner GC Zhu T Zhong J 2013 The relation between posttraumatic stress disorder and mild traumatic brain injury acquired during Operations Enduring Freedom and Iraqi Freedom Journal of Head Trauma Rehabilitation 28 1 12 22647965
  7. Bazarian JJ Zhong J Blyth B Zhu T Kavcic V Peterson D 2007 Diffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: A pilot study Journal of Neurotrauma 24 1447 1459 17892407
  8. Bazarian JJ Zhu T Blyth B Borrino A Zhong J 2012 Subject-specific changes in brain white matter on diffusion tensor imaging after sports-related concussion Magnetic Resonance Imaging 30 171 180 22079073 PMC3254806
  9. Begonia M Prabhu R Liao J Whittington W Claude A Willeford B Wardlaw J Williams L 2014 Quantitative analysis of brain microstructure following mild blunt and blast trauma Journal of Biomechanics 47 15 3704 3711 25446270
  10. Bendlin BB Ries ML Lazar M Alexander AL Dempsey RJ Rowley HA Johnson SC 2008 Longitudinal changes in patients with traumatic brain injury assessed with diffusion-tensor and volumetric imaging Neuroimage 42 503 514 18556217 PMC2613482
  11. Bigler ED 2001 The lesion (s) in traumatic brain injury: Implications for clinical neuropsychology Archives of Clinical Neuropsychology 16 95 131 14590180
  12. Bigler ED 2013a Neuroinflammation and the dynamic lesion in traumatic brain injury Brain 136 9 11 23365089
  13. Bigler ED 2013b Traumatic brain injury, neuroimaging, and neurodegeneration Frontiers in Human Neuroscience 7 395 23964217 PMC3734373
  14. Bigler ED Abildskov TJ Wilde EA McCauley SR Li X Merkley TL Levin HS 2010 Diffuse damage in pediatric traumatic brain injury: A comparison of automated versus operator-controlled quantification methods Neuroimage 50 1017 1026 20060915
  15. Bigler ED Maxwell WL 2012 Neuropathology of mild traumatic brain injury: Relationship to neuroimaging findings Brain Imaging and Behavior 6 108 136 22434552
  16. Blumbergs PC Scott G Vis JM Wainwright H Simpson DA McLean AJ 1995 Topography of axonal injury as defined by amyloid precursor protein and the sector scoring method in mild and severe closed head injury Journal of Neurotrauma 12 4 565 572 8683607
  17. Bonelle V Leech R MKinnunen K Ham T Beckmann C De Boissezon X Sharp D 2011 Default mode network connectivity predicts sustained attention deficits after traumatic brain injury The Journal of Neuroscience 31 13442 13451 21940437 PMC6623308
  18. Bouix S Pasternak O Rathi Y Pelavin PE Zafonte R Shenton ME 2013 Increased gray matter diffusion anisotropy in patients with persistent post-concussive symptoms following mild traumatic brain injury PLoS One 8 6 e66205 23776631 PMC3679020
  19. Bramlett HM Dietrich WD (in press) Long-term consequences of traumatic brain injury: Current status of potential mechanisms of injury and neurological outcomes Journal of Neurotrauma 10.1089/neu.2014.3352 PMC4677116 25158206 · DOI
  20. Caeyenberghs K Leemans A Geurts M Taymans T Vander Linden C Smits-Engelsman BCM Swinnen SP 2010 Brain-behavior relationships in young traumatic brain injury patients: Fractional anisotropy measures are highly correlated with dynamic visuomotor tracking performance Neuropsychologia 48 5 1472 1482 20117121
  21. Catani M 2005 The rises and falls of disconnection syndromes Brain 128 10 2224 2239 16141282
  22. Catani M Dell’Acqua F Thiebaut de Schotten M 2013 A revised limbic system model for memory, emotion and behaviour Neuroscience & Biobehavioral Reviews 37 1724 1737 23850593
  23. Catani M Thiebaut de Schotten M 2008 A diffusion tensor imaging tractography atlas for virtual in vivo dissections Cortex 44 1105 1132 18619589
  24. Choudhri AF Chin EM Blitz AM Gandhi D 2014 Diffusion tensor imaging of cerebral white matter Radiologic Clinics of North America 52 413 425 24582347
  25. Cole DM Smith SM Beckmann CF 2010 Advances and pitfalls in the analysis and interpretation of resting-state FMRI data Frontiers in Systems Neuroscience 4 8 20407579 PMC2854531
  26. Corbetta M 2012 Functional connectivity and neurological recovery Developmental Psychobiology 54 239 253 22415913
  27. Costanzo ME Chou Y-Y Leaman S Pham DL Keyser D Nathan DE Roy MJ 2014 Connecting combat-related mild traumatic brain injury with posttraumatic stress disorder symptoms through brain imaging Neuroscience Letters 577 11 15 24907686
  28. Davenport ND Lim KO Armstrong MT Sponheim SR 2012 Diffuse and spatially variable white matter disruptions are associated with blast-related mild traumatic brain injury Neuroimage 59 2017 2024 22040736
  29. Davenport ND Lim KO Sponheim SR 2015 White matter abnormalities associated with military PTSD in the context of blast TBI Human Brain Mapping 36 3 1053 1064 25387950 PMC6869802
  30. Fagerholm ED Hellyer PJ Scott G Leech R Sharp DJ 2015 Disconnection of network hubs and cognitive impairment after traumatic brain injury Brain 138 6 1696 1709 25808370 PMC4614120
  31. Fakhran S Yaeger K Alhilali L 2013 Symptomatic white matter changes in mild traumatic brain injury resemble pathologic features of early Alzheimer dementia Radiology 269 249 257 23781117
  32. Farbota KD Bendlin BB Alexander AL Rowley HA Dempsey RJ Johnson SC 2012 Longitudinal diffusion tensor imaging and neuropsychological correlates in traumatic brain injury patients Frontiers in Human Neuroscience 6 160 22723773 PMC3378081
  33. Gale SD Johnson SC Bigler ED Blatter DD 1995 Nonspecific white matter degeneration following traumatic brain injury Journal of the International Neuropsychological Society 1 1 17 28 9375205
  34. Gardner A Kay-Lambkin F Stanwell P Donnelly J Williams WH Hiles A Jones DK 2012 A systematic review of diffusion tensor imaging findings in sports-related concussion Journal of Neurotrauma 29 2521 2538 22950876
  35. Geary EK Kraus MF Pliskin NH Little DM 2010 Verbal learning differences in chronic mild traumatic brain injury Journal of the International Neuropsychological Society 16 506 20188015
  36. Gentry LR Thompson B Godersky JC 1988 Trauma to the corpus callosum: MR features AJNR: American Journal of Neuroradiology 9 6 1129 1138 3143234 PMC8331914
  37. Geschwind N 1965 Disconnexion syndromes in animals and man Brain 88 3 585 585 5318824
  38. Goetz P Blamire A Rajagopalan B Cadoux-Hudson T Young D Styles P 2004 Increase in apparent diffusion coefficient in normal appearing white matter following human traumatic brain injury correlates with injury severity Journal of Neurotrauma 21 645 654 15253793
  39. Greenberg G Mikulis DJ Ng K DeSouza D Green RE 2008 Use of diffusion tensor imaging to examine subacute white matter injury progression in moderate to severe traumatic brain injury Archives of Physical Medicine and Rehabilitation 89 S45 S50 19081441
  40. Grossman EJ Jensen JH Babb JS Chen Q Tabesh A Fieremans E Grossman RI 2013 Cognitive impairment in mild traumatic brain injury: A longitudinal diffusional kurtosis and perfusion imaging study AJNR: American Journal of Neuroradiology 34 951 957 23179649 PMC3908903
  41. Håberg A Olsen A Moen K Schirmer-Mikalsen K Visser E Finnanger T Eikenes L 2015 White matter micro-structure in chronic moderate-to-severe traumatic brain injury: Impact of acute-phase injury-related variables and associations with outcome measures Journal of Neuroscience Research 93 1109 1126 25641684
  42. Ham TE Bonnelle V Hellyer P Jilka S Robertson IH Leech R Sharp DJ 2014 The neural basis of impaired self-awareness after traumatic brain injury Brain 137 2 586 597 24371217 PMC3914476
  43. Hartikainen KM Wäljas M Isoviita T Dastidar P Liimatainen S Solbakk A-K Öhman J 2010 Persistent symptoms in mild to moderate traumatic brain injury associated with executive dysfunction Journal of Clinical and Experimental Neuropsychology 32 767 774 20198531
  44. Hayes JP Miller DR Lafleche G Salat DH Verfaellie M 2015 The nature of white matter abnormalities in blast-related mild traumatic brain injury Neuroimage: Clinical 8 148 156 26106539 PMC4473287
  45. Hayes JP Morey RA Tupler LA 2012 A case of frontal neuropsychological and neuroimaging signs following multiple primary-blast exposure Neurocase 18 258 269 21879996 PMC3718065
  46. Hellyer PJ Leech R Ham TE Bonnelle V Sharp DJ 2013 Individual prediction of white matter injury following traumatic brain injury: Multivariate analysis of white matter after TBI Annals of Neurology 73 489 499 23426980
  47. Henry LC Tremblay J Tremblay S Lee A Brun C Lepore N Lassonde M 2011 Acute and chronic changes in diffusivity measures after sports concussion Journal of Neurotrauma 28 2049 2059 21864134
  48. Hillary F Rajtmajer S Roman C Medaglia J Slocomb-Dluzen J Calhoun V Wylie G 2014 The rich get richer: Brain injury elicits hyperconnectivity in core subnetworks PLoS One 9 1 15 PMC4133194 25121760
  49. Hillary F Roman C Venkatesan U Rajtmajer S 2015 Hyperconnectivity is a fundamental response to neurological disruption Neuropsychology 29 59 75 24933491
  50. Hillary F Slocomb J Hills E Fitzpatrick N Medaglia J Wang J Wylie G 2011 Changes in resting connectivity during recovery from severe traumatic brain injury International Journal of Psychophysiology 82 115 123 21473890
  51. Hou DJ Tong KA Ashwal S Oyoyo U Joo E Shutter L Obenaus A 2007 Diffusion-weighted magnetic resonance imaging improves outcome prediction in adult traumatic brain injury Journal of Neurotrauma 24 1558 1569 17970619
  52. Huisman TA Schwamm LH Schaefer PW Koroshetz WJ Shetty-Alva N Ozsunar Y Sorensen AG 2004 Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury AJNR: American Journal of Neuroradiology 25 3 370 376 15037457 PMC8158566
  53. Hulkower MB Poliak DB Rosenbaum SB Zimmerman ME Lipton ML 2013 A decade of DTI in traumatic brain injury: 10 years and 100 articles later AJNR: American Journal of Neuroradiology 34 2064 2074 23306011 PMC7964847
  54. Ilvesmaki T Luoto TM Hakulinen U Brander A Ryymin P Eskola H Ohman J 2014 Acute mild traumatic brain injury is not associated with white matter change on diffusion tensor imaging Brain 137 1876 1882 24818956
  55. Inglese M Makani S Johnson G Cohen BA Silver JA Gonen O Grossman RI 2005 Diffuse axonal injury in mild traumatic brain injury: A diffusion tensor imaging study Journal of Neurosurgery 103 298 303 16175860
  56. Irimia A Chambers MC Torgerson CM Filippou M Hovda DA Alger JR Kikinis R 2012 Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury Frontiers in Neurology 3 10 22363313 PMC3275792
  57. Irimia A Goh S-Y Torgerson C Vespa P Van Horn J 2014 Structural and connectomic neuroimaging for the personalized study of longitudinal alterations in cortical shape, thickness and connectivity after traumatic brain injury Journal of Neurosurgical Sciences 58 3 129 24844173 PMC4158854
  58. Jilka S Scott G Ham T Pickering A Bonelle V Braga R Sharp D 2014 Damage to the salience network and interactions with the default mode network The Journal of Neuroscience 34 10798 10807 25122883 PMC4131006
  59. Johnson B Zhang K Gay M Horovitz S Hallett M Sebastianelli W Slobounov S 2012 Alteration of brain default network in subacute phase of injury in concussed individuals: Resting-state fMRI study Neuroimage 59 511 518 21846504 PMC3196274
  60. Johnson VE Stewart JE Begbie FD Trojanowski JQ Smith DH Stewart W 2013 Inflammation and white matter degeneration persist for years after a single traumatic brain injury Brain 136 28 42 23365092 PMC3562078
  61. Jones D 2008 Studying connections in the living human brain with diffusion MRI Cortex 44 936 952 18635164
  62. Jorge RE Acion L White T Tordesillas-Gutierrez D Pierson R Crespo-Facorro B Magnotta VA 2012 White matter abnormalities in veterans with mild traumatic brain injury American Journal of Psychiatry 169 1284 1291 23212059 PMC4030599
  63. Kennedy MRT Wozniak JR Muetzel RL Mueller BA Chiou H-H Pantekoek K Lim KO 2009 White matter and neurocognitive changes in adults with chronic traumatic brain injury Journal of the International Neuropsychological Society 15 130 136 19128536 PMC2895769
  64. Kim N Branch CA Kim M Lipton ML 2013 Whole brain approaches for identification of microstructural abnormalities in individual patients: Comparison of techniques applied to mild traumatic brain injury PLoS One 8 e59382 23555665 PMC3608654
  65. Kinnunen KM Greenwood R Powell JH Leech R Hawkins PC Bonnelle V Sharp DJ 2011 White matter damage and cognitive impairment after traumatic brain injury Brain 134 449 463 21193486 PMC3030764
  66. Koerte IK Ertl-Wagner B Reiser M Zafonte R Shenton ME 2012 White matter integrity in the brains of professional soccer players without a symptomatic concussion Journal of the American Medical Association 308 18 1859 1861 23150002 PMC4103415
  67. Koerte IK Kaufmann D Hartl E Bouix S Pasternak O Kubicki M Shenton ME 2012 A prospective study of physician-observed concussion during a varsity university hockey season: White matter integrity in ice hockey players. Part 3 of 4 Neurosurgical Focus 33 E3 PMC5687247 23199426
  68. Kraus MF Susmaras T Caughlin BP Walker CJ Sweeney JA Little DM 2007 White matter integrity and cognition in chronic traumatic brain injury: A diffusion tensor imaging study Brain 130 2508 2519 17872928
  69. Kumar R Saksena S Husain M Srivastava A Rathore RK Agarwal S Gupta RK 2010 Serial changes in diffusion tensor imaging metrics of corpus callosum in moderate traumatic brain injury patients and their correlation with neuropsychometric tests: A 2-year follow-up study Journal of Head Trauma Rehabilitation 25 31 42 20051898
  70. Lange RT Iverson GL Brubacher JR Mädler B Heran MK 2012 Diffusion tensor imaging findings are not strongly associated with postconcussional disorder 2 months following mild traumatic brain injury Journal of Head Trauma Rehabilitation 27 3 188 198 21642855
  71. Lange RT Panenka WJ Shewchuk JR Heran MKS Brubacher JR Bioux S Iverson GL 2015 Diffusion tensor imaging findings and postconcussion symptom reporting six weeks following mild traumatic brain injury Archives of Clinical Neuropsychology 30 1 7 25 25416729
  72. Levin HS Wilde E Troyanskaya M Petersen NJ Scheibel R Newsome M Li X 2010 Diffusion tensor imaging of mild to moderate blast-related traumatic brain injury and its sequelae Journal of Neurotrauma 27 683 694 20088647
  73. Ling JM Pena A Yeo RA Merideth FL Klimaj S Gasparovic C Mayer AR 2012 Biomarkers of increased diffusion anisotropy in semi-acute mild traumatic brain injury: A longitudinal perspective Brain 135 1281 1292 22505633 PMC3326260
  74. Lipton ML Gellella E Lo C Gold T Ardekani BA Shifteh K Branch CA 2008 Multifocal white matter ultrastructural abnormalities in mild traumatic brain injury with cognitive disability: A voxel-wise analysis of diffusion tensor imaging Journal of Neurotrauma 25 1335 1342 19061376
  75. Lipton ML Gulko E Zimmerman ME Friedman BW Kim M Gellella E Branch CA 2009 Diffusion-tensor imaging implicates prefrontal axonal injury in executive function impairment following very mild traumatic brain injury Radiology 252 816 824 19567646
  76. Lipton ML Kim N Park YK Hulkower MB Gardin TM Shifteh K Branch CA 2012 Robust detection of traumatic axonal injury in individual mild traumatic brain injury patients: Intersubject variation, change over time and bidirectional changes in anisotropy Brain Imaging and Behavior 6 329 342 22684769
  77. Little DM Kraus MF Joseph J Geary EK Susmaras T Zhou XJ Pliskin N Gorelick PB 2010 Thalamic integrity underlies executive dysfunction in traumatic brain injury Neurology 74 558 564 20089945 PMC2830915
  78. Ljungqvist J Nilsson D Ljungberg M Sörbo A Esbjörnsson E Eriksson-Ritzén C Skoglund T 2011 Longitudinal study of the diffusion tensor imaging properties of the corpus callosum in acute and chronic diffuse axonal injury Brain Injury 25 370 378 21355671
  79. Lo C Shifteh K Gold T Bello JA Lipton ML 2009 Diffusion tensor imaging abnormalities in patients with mild traumatic brain injury and neurocognitive impairment Journal of Computer Assisted Tomography 33 2 293 297 19346863
  80. Mac Donald CL Adam OR Johnson AM Nelson EC Werner NJ Rivet DJ Brody DL 2015 Acute post-traumatic stress symptoms and age predict outcome in military blast concussion Brain 138 5 1314 1326 25740219 PMC5963403
  81. Mac Donald CL Dikranian K Song SK Bayly PV Holtzman DM Brody DL 2007 Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury Experimental Neurology 205 1 116 131 17368446 PMC1995439
  82. Mac Donald CL Johnson AM Cooper D Nelson EC Werner NJ Shimony JS Brody DL 2011 Detection of blast-related traumatic brain injury in U.S. military personnel New England Journal of Medicine 364 2091 2100 21631321 PMC3146351
  83. Marquez de la Plata C Garces J Kojori E Grinnan J Krishnan K Pidikiti R Diaz-Arrastia R 2011 Deficits in functional connectivity of hippocampal and frontal lobe circuits after traumatic axonal injury Archives of Neurology 68 74 84 21220676 PMC3100186
  84. Matsukawa H Shinoda M Fujii M Takahashi O Yamamoto D Murakata A Ishikawa R 2011 Genu of corpus callosum in diffuse axonal injury induces a worse 1-year outcome in patients with traumatic brain injury Acta Neurochirurgica 153 8 1687 1694 21479582
  85. Matthews SC Strigo IA Simmons AN O’Connell RM Reinhardt LE Moseley SA 2011 A multimodal imaging study in US veterans of Operations Iraqi and Enduring Freedom with and without major depression after blast-related concussion Neuroimage 54 S69 S75 20451622
  86. Mayer AR Mannell M Ling J Gasparovic C Yeo R 2011 Functional connectivity in mild traumatic brain injury Human Brain Mapping 32 1825 1835 21259381 PMC3204375
  87. McCrea M Iverson GL McAllister TW Hammeke TA Powell MR Barr WB Kelly JP 2009 An integrated review of recovery after mild traumatic brain injury (MTBI): Implications for clinical management The Clinical Neuropsychologist 23 8 1368 1390 19882476
  88. McKee AC Stein TD Nowinski CJ Stern RA Daneshvar DH Alvarez VE Baugh CM 2013 The spectrum of disease in chronic traumatic encephalopathy Brain 136 1 43 64 23208308 PMC3624697
  89. Messé A Caplain S Paradot G Garrigue D Mineo J-F Soto Ares G Lehéricy S 2011 Diffusion tensor imaging and white matter lesions at the subacute stage in mild traumatic brain injury with persistent neurobehavioral impairment Human Brain Mapping 32 999 1011 20669166 PMC6870077
  90. Messé A Caplain S Pélégrini-Issac M Blancho S Lévy R Aghakhani N Lehéricy S 2013 Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury PLoS One 8 1 10 PMC5784652 29364946
  91. Messé A Caplain S Pélégrini-Issac M Blancho S Montreuil M Lévy R Benali H 2012 Structural integrity and postconcussion syndrome in mild traumatic brain injury patients Brain Imaging and Behavior 6 283 292 22477019
  92. Meythaler JM Peduzzi JD Eleftheriou E Novack TA 2001 Current concepts: Diffuse axonal injury-associated traumatic brain injury Archives of Physical Medicine and Rehabilitation 82 1461 1471 11588754
  93. Miles L Grossman RI Johnson G Babb JS Diller L Inglese M 2008 Short-term DTI predictors of cognitive dysfunction in mild traumatic brain injury Brain Injury 22 2 115 122 18240040
  94. Miller BT D’Esposito M 2005 Searching for “the top” in top-down control Neuron 48 4 535 538 16301170
  95. Moen KG Håberg AK Skandsen T Finnanger TG Vik A 2014 A longitudinal magnetic resonance imaging study of the apparent diffusion coefficient values in corpus callosum during the first year after traumatic brain injury Journal of Neurotrauma 31 56 63 23837731 PMC3880061
  96. Morey RA Haswell CC Selgrade ES Massoglia D Liu C Weiner J McCarthy G 2013 Effects of chronic mild traumatic brain injury on white matter integrity in Iraq and Afghanistan war veterans: Effects of TBI on white matter integrity Human Brain Mapping 34 2986 2999 22706988 PMC3740035
  97. Nakamura T Hillary F Biswal B 2009 Resting network plasticity following brain injury PLoS One 4 1 9 PMC2788622 20011533
  98. Nakayama N 2006 Evidence for white matter disruption in traumatic brain injury without macroscopic lesions Journal of Neurology, Neurosurgery, & Psychiatry 77 850 855 PMC2117497 16574734
  99. Newcombe VF Correia MM Ledig C Abate MG Outtrim JG Chatfield D Pickard JD 2015 Dynamic changes in white matter abnormalities correlate with late improvement and deterioration following TBI: A diffusion tensor imaging study Neurorehabilitation and Neural Repair 10.1177/1545968315584004 25921349 · DOI
  100. Newcombe VFJ Williams GB Nortje J Bradley PG Harding SG Smielewski P Menon DK 2007 Analysis of acute traumatic axonal injury using diffusion tensor imaging British Journal of Neurosurgery 21 340 348 17676452
  101. Niogi SN Mukherjee P Ghajar J Johnson CE Kolster R Lee H McCandliss BD 2008 Structural dissociation of attentional control and memory in adults with and without mild traumatic brain injury Brain 131 3209 3221 18952679
  102. Ommaya AK Gennarelli TA 1974 Cerebral concussion and traumatic unconsciousness. Correlation of experimental and clinical observations of blunt head injuries Brain 97 633 654 4215541
  103. Pal D Gupta RK Agarwal S Yadav A Ojha BK Awasthi A Narayana PA 2012 Diffusion tensor tractography indices in patients with frontal lobe injury and its correlation with neuropsychological tests Clinical Neurology and Neurosurgery 114 564 571 22209144
  104. Palacios E Sala-Llonch R Junque C Roig T Tormos J Bargallo N Vendrell P 2012 White matter integrity related to functional working memory networks in traumatic brain injury Neurology 78 852 860 22345222
  105. Palacios E Sala-Llonch R Junque C Roig T Tormos J Bargallo N Vendrell P 2013 Resting-state functional magnetic resonance imaging activity and connectivity and cognitive outcome in traumatic brain injury JAMA Neurology 70 845 851 23689958
  106. Peerless SJ Rewcastle NB 1967 Shear injuries of the brain Canadian Medical Association Journal 96 577 6020206 PMC1936040
  107. Perlbarg V Puybasset L Tollard E Lehéricy S Benali H Galanaud D 2009 Relation between brain lesion location and clinical outcome in patients with severe traumatic brain injury: A diffusion tensor imaging study using voxel-based approaches Human Brain Mapping 30 3924 3933 19507154 PMC6870894
  108. Petrie EC Cross DJ Yarnykh VL Richards T Martin NM Pagulayan K Peskind ER 2014 Neuroimaging, behavioral, and psychological sequelae of repetitive combined blast/impact mild traumatic brain injury in Iraq and Afghanistan War Veterans Journal of Neurotrauma 31 425 436 24102309 PMC3934596
  109. Povlishock JT Becker DP Cheng CLY Vaughan GW 1983 Axonal change in minor head injury Journal of Neuropathology & Experimental Neurology 42 3 225 242 6188807
  110. Povlishock JT Christman CW 1995 The pathobiology of traumatically induced axonal injury in animals and humans: A review of current thoughts Journal of Neurotrauma 12 555 564 8683606
  111. Reinarz SJ Coffman CE Smoker WR Godersky JC 1988 MR imaging of the corpus callosum: Normal and pathologic findings and correlation with CT AJNR: American Journal of Neuroradiology 9 649 656 3262282
  112. Ruff RL Riechers RG Wang X-F Piero T Ruff SS 2012 A case-control study examining whether neurological deficits and PTSD in combat veterans are related to episodes of mild TBI BMJ Open 2 1 12 PMC3312078 22431700
  113. Ruppin E Reggia J 1995 Patterns of functional damage in neural network models of associative memory Neural Computation 7 1105 1127 7584889
  114. Ryu J Horkayne-Szakaly I Xu L Pletnikova O Leri F Eberhart C Koliatsos VE 2014 The problem of axonal injury in the brains of veterans with histories of blast exposure Acta Neuropathologica Communications 2 1 14 25422066 PMC4260204
  115. Salmond CH Menon DK Chatfield DA Williams GB Pena A Sahakian BJ Pickard JD 2006 Diffusion tensor imaging in chronic head injury survivors: Correlations with learning and memory indices Neuroimage 29 117 124 16084738
  116. Sharp D Beckmann C Greenwood R Kinnunen K Bonelle V De Boissezon X Leech R 2011 Default mode network functional and structural connectivity after traumatic brain injury Brain 134 2233 2247 21841202
  117. Sharp D Scott G Leech R 2014 Network dysfunction after traumatic brain injury Nature Reviews Neurology 10 156 166 24514870
  118. Shenton ME Hamoda HM Schneiderman JS Bouix S Pasternak O Rathi Y Zafonte R 2012 A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury Brain Imaging and Behavior 6 137 192 22438191 PMC3803157
  119. Shumskaya E Andriessen T Norris D Vos P 2012 Abnormal whole-brain functional networks in homogeneous acute mild traumatic brain injury Neurology 79 175 182 22744656
  120. Sidaros A Engberg AW Sidaros K Liptrot MG Herning M Petersen P Rostrup E 2008 Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: A longitudinal study Brain 131 559 572 18083753
  121. Skoglund TS Nilsson D Ljungberg M Jönsson L Rydenhag B 2008 Long-term follow-up of a patient with traumatic brain injury using diffusion tensor imaging Acta Radiologica 49 98 100 17963089
  122. Smith DH Meaney DF Shull WH 2003 Diffuse axonal injury in head trauma Journal of Head Trauma Rehabilitation 18 307 316 16222127
  123. Smits M Houston GC Dippel DWJ Wielopolski PA Vernooij MW Koudstaal PJ van Der Lugt A 2011 Microstructural brain injury in post-concussion syndrome after minor head injury Neuroradiology 53 8 553 563 20924757 PMC3139069
  124. Sorg SF Delano-Wood L Luc N Schiehser DM Hanson KL Nation DA Meloy M 2013 White matter integrity in veterans with mild traumatic brain injury: Associations with executive function and loss of consciousness The Journal of Head Trauma Rehabilitation 29 1 21 32 PMC4300196 23640539
  125. Sours C Zhuo J Janowich J Aarabi B Shanmuganathan K Gullapalli R 2013 Default mode network interference in mild traumatic brain injury - A pilot resting state study Brain Research 1537 201 215 23994210 PMC3835746
  126. Sporns O 2014 Contributions and challenges for network models in cognitive neuroscience Nature Neuroscience 17 652 660 24686784
  127. Stevens M Lovejoy D Kim J Oakes H Kureshi I Witt S 2012 Multiple resting state network functional connectivity abnormalities in mild traumatic brain injury Brain Imaging and Behavior 6 293 318 22555821
  128. Strich SJ 1956 Diffuse degeneration of the cerebral white matter in severe dementia following head injury Journal of Neurology, Neurosurgery, and Psychiatry 19 163 PMC497203 13357957
  129. Suskauer SJ Huisman TA 2009 Neuroimaging in pediatric traumatic brain injury: Current and future predictors of functional outcome Developmental Disabilities Research Reviews 15 2 117 123 19489082 PMC3167090
  130. Taber KH Hurley RA 2013 Update on mild traumatic brain injury: Neuropathology and structural imaging The Journal of Neuropsychiatry and Clinical Neurosciences 25 1 1 5 23487187
  131. Taber KH Hurley RA Haswell CC Rowland JA Hurt SD Lamar CD Morey RA 2015 White matter compromise in veterans exposed to primary blast forces Journal of Head Trauma Rehabilitation 30 1 E15 E25 24590156 PMC4470620
  132. Tang L Ge Y Sodickson D Miles L Zhou Y Reaume J Grossman R 2011 Thalamic resting-state functional networks: Disruption in patients with mild traumatic brain injury Radiology 260 831 840 21775670 PMC3157002
  133. Tate DF Bigler ED 2000 Fornix and hippocampal atrophy in traumatic brain injury Learning & Memory 7 6 442 446 11112803
  134. Tomaszczyk JC Green NL Frasca D Colella B Turner GR Christensen BK Green REA 2014 Negative neuroplasticity in chronic traumatic brain injury and implications for neurorehabilitation Neuropsychology Review 24 409 427 25421811 PMC4250564
  135. Tournier JD Mori S Leemans A 2011 Diffusion tensor imaging and beyond Magnetic Resonance in Medicine 65 6 1532 1556 21469191 PMC3366862
  136. van den Heuvel MP Sporns O 2011 Rich-club organization of the human connectome The Journal of Neuroscience 31 44 15775 15786 22049421 PMC6623027
  137. Venkatesan U Dennis N Hillary F 2015 Chronology and chronicity of altered resting-state functional connectivity after traumatic brain injury Journal of Neurotrauma 32 252 264 24955788 PMC4347859
  138. Voss HU Uluç AM Dyke JP Watts R Kobylarz EJ McCandliss BD Vallabhajosula S 2006 Possible axonal regrowth in late recovery from the minimally conscious state Journal of Clinical Investigation 116 7 2005 16823492 PMC1483160
  139. Wäljas M Lange RT Hakulinen U Huhtala H Dastidar P Hartikainen K Iverson GL 2014 Biopsychosocial outcome after uncomplicated mild traumatic brain injury Journal of Neurotrauma 31 1 108 124 23978227
  140. Wang JY Bakhadirov K Abdi H Devous MD Marquez de la Plata CD Moore C Diaz-Arrastia R 2011 Longitudinal changes of structural connectivity in traumatic axonal injury Neurology 77 818 826 21813787 PMC3162636
  141. Warden DL French LM Shupenko L Fargus J Riedy G Erickson ME Moore DF 2009 Case report of a soldier with primary blast brain injury Neuroimage 47 T152 T153 19457364
  142. Watts R Thomas A Filippi CG Nickerson JP Freeman K 2014 Potholes and molehills: Bias in the diagnostic performance of diffusion-tensor imaging in concussion Radiology 272 1 217 223 24635677 PMC4263643
  143. Wilde EA Hunter JV Bigler ED 2012 Neuroimaging in neurorehabilitation NeuroRehabilitation 31 223 226 23093451
  144. Xu J Rasmussen I-A Lagopoulos J Håberg A 2007 Diffuse axonal injury in severe traumatic brain injury visualized using high-resolution diffusion tensor imaging Journal of Neurotrauma 24 5 753 765 17518531
  145. Yeh PH Wang B Oakes TR French LM Pan H Graner J Riedy G 2014 Postconcussional disorder and PTSD symptoms of military-related traumatic brain injury associated with compromised neurocircuitry: Neurocircuitry in military TBI and clinical symptoms Human Brain Mapping 35 2652 2673 24038816 PMC6869078
  146. Yeo B Krienen F Sepulcre J Sabuncu M Lashkari D Hollinshead M Buckner R 2011 The organization of the human cerebral cortex estimated by intrinsic functional connectivity Journal of Neurophysiology 106 1125 1165 21653723 PMC3174820
  147. Yuh EL Cooper SR Mukherjee P Yue JK Lingsma HF Gordon WA Vassar MJ 2014 Diffusion tensor imaging for outcome prediction in mild traumatic brain injury: A TRACK-TBI study Journal of Neurotrauma 31 17 1457 1477 24742275 PMC4144386
  148. Zhang S Li CS 2012 Functional connectivity mapping of the human precuneus by resting state fMRI Neuroimage 59 3548 3562 22116037 PMC3288461
  149. Zhou Y Lui Y Zuo X Milham M Reaume J Grossman R Ge Y 2014 Characterization of thalamo-cortical association using amplitude and connectivity of functional MRI in mild traumatic brain injury Journal of Magnetic Resonance Imaging 39 1558 1568 24014176 PMC3872273
  150. Zhou Y Milham M Lui Y Miles L Reaume J Sodickson D Ge Y 2012 Default-mode network disruption in mild traumatic brain injury Radiology 265 882 892 23175546 PMC3504316

Cited by

Sorted by citations

Authors
Hayes, J. P., Bigler, E. D., & Verfaellie, M.
Affiliations
  • Boston University (US)
  • Brigham Young University (US)
Corresponding author
Hayes, Jasmeet P.
ORCID
Venue
Journal of the International Neuropsychological Society
Publisher
Cambridge University Press (CUP)
Published
2016-02
Volume
22
Issue
2
Pages
120-137
ISSN
  • 1355-6177 (ISSN-L)
  • 1469-7661
DOI
10.1017/s1355617715000740
PMC
PMC5734864
OpenAlex
W2285064633
Cited by
242
References
12
Citations by year
2026: 22 · 2025: 26 · 2024: 28 · 2023: 20 · 2022: 18 · 2021: 42 · 2020: 17 · 2019: 20 · 2018: 22 · 2017: 20 · 2016: 7
FWCI
3.11
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 17 d)
Locations
  • Journal of the International Neuropsychological Society (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Veterans Affairs (I21 RX001594)
  • Rehabilitation Research and Development Service
  • Clinical Science Research and Development
  • National Center for PTSD, U.S. Department of Veterans Affairs
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
traumatic brain injury, brain connectivity, white matter integrity, axonal injury, resting-state functional connectivity, structural MRI, functional MRI, artificial neural networks, neurocognitive impairment, injury recovery, injury severity
MeSH terms
Brain Injuries, Traumatic, Brain, Brain Mapping, Humans, Neural Pathways, Neuroimaging

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