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Cited by 6Chemotherapy-related skin toxicityEffects of Radiation ExposureOral health in cancer treatment

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Keratin-based topical cream for radiation dermatitis during head and neck radiotherapy: a randomised, open-label pilot study

Open access
Hughes, Ryan T, Levine, Beverly J, Frizzell, Bart A, Greven, Kathryn M, Porosnicu, Mercedes, Lycan, Thomas W, Burnett, Luke R, Winkfield, Karen M·2024·Journal of Radiotherapy in Practice
DOI 10.1017/s1460396924000037PMC PMC11449460
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Abstract

Introduction: Radiation dermatitis (RD) is a frequent toxicity during radiotherapy (RT) for head and neck cancer (HNC). We report the first use of KeraStat® Cream (KC), a topical, keratin-based wound dressing, in patients with HNC receiving RT. Methods: This pilot study randomized HNC patients treated with definitive or postoperative RT (≥60 Gy) to KC or standard of care (SOC), applied at least twice daily during and for 1-month after RT. Outcomes of interest included adherence to the assigned regimen (at least 10 applications per week of treatment), clinician- and patient-reported RD, and skin-related quality of life. Results: 24 patients were randomized and completed the study. Most patients had stage III-IV disease and oropharynx cancer. Median RT dose was 68 Gy; the bilateral neck was treated in 19 patients, and 18 patients received concurrent chemotherapy. Complete adherence was observed in 7/12 (SOC) vs. 10/12 (KC, p = 0.65). Adherence by patient-week was 61/68 versus 64/67, respectively (p = 0.20). No differences in RD were observed between groups. Conclusion: A randomized trial of KC versus SOC in HNC patients treated with RT is feasible with good adherence to study agent. An adequately powered randomized study is warranted to test the efficacy of KC in reducing RD.

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Registry

Crossref · 10.1017/s1460396924000037

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1. Mean radiation dermatitis CTCAE grade between groups. Error bars indicate standard error.
Figure 1. Mean radiation dermatitis CTCAE grade between groups. Error bars indicate standard error.CC BY · PubMed Central
Figure 2. Mean PRO-CTCAE scores for radiation skin reaction (a), itching (b) and skin dryness (c) between groups. Error bars indicate standard error.
Figure 2. Mean PRO-CTCAE scores for radiation skin reaction (a), itching (b) and skin dryness (c) between groups. Error bars indicate standard error.CC BY · PubMed Central
Figure 3. Mean DLQI score between groups. Error bars indicate standard error.
Figure 3. Mean DLQI score between groups. Error bars indicate standard error.CC BY · PubMed Central

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Metadata

Authors
Hughes, R. T., Levine, B. J., Frizzell, B. A., Greven, K. M., Porosnicu, M., Lycan, T. W., Burnett, L. R., & Winkfield, K. M.
Affiliations
  • Wake Forest University Health Sciences (US)
  • Wake Forest University (US)
  • KeraNetics (United States) (US)
  • Vanderbilt University Medical Center (US)
Corresponding author
Hughes, Ryan T
ORCID
Venue
Journal of Radiotherapy in Practice
Publisher
Cambridge University Press (CUP)
Published
2024
Volume
23
ISSN
  • 1460-3969 (ISSN-L)
  • 1467-1131
DOI
10.1017/s1460396924000037
PMC
PMC11449460
OpenAlex
W4394813419
Cited by
6
References
49
Citations by year
2026: 4 · 2025: 2
FWCI
2.45
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Radiotherapy in Practice (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion, cc-by)
Funders
  • Wake Forest University (P30 CA012197, UG1CA189824)
  • Comprehensive Cancer Center at Wake Forest Baptist Medical Center (P30CA012197)
  • National Cancer Institute (UG1CA189824, P30CA012197, R01CA262041)
Topics
  • Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Dentistry › General Dentistry › Oral health in cancer treatment
Keywords
radiation dermatitis, head and neck cancer, topical cream, radiotherapy toxicity, skin-related quality of life, medication adherence, oropharyngeal cancer, neck irradiation

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