Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-d-aspartic acid receptor up-regulation
Open accessAbstract
Abnormalities in glutamatergic signalling are proposed in schizophrenia in light of the schizophreniform psychosis elicited by NMDA antagonists. The metabotropic glutamate receptor 5 (mGluR5) interacts closely with the NMDA receptor and is implicated in several behavioural endophenotypes of schizophrenia. We have demonstrated that mice lacking mGluR5 have increased sensitivity to the hyperlocomotive effects of the NMDA antagonist MK-801. Mice lacking mGluR5 also show abnormal locomotor patterns, reduced prepulse inhibition (PPI), and deficits on performance of a short-term spatial memory task on the Y-maze. Chronic administration of the antipsychotic drug clozapine ameliorated the locomotor disruption and reversed the PPI deficit, but did not improve Y-maze performance. Chronic clozapine increased NMDA receptor binding ([3H]MK-801) but did not alter dopamine D2 ([3H]YM-09151), 5-HT2A ([3H]ketanserin), or muscarinic M1/M4 receptor ([3H]pirenzepine), binding in these mice. These results demonstrate behavioural abnormalities that are relevant to schizophrenia in the mGluR5 knockout mouse and a reversal of behaviours with clozapine treatment. These results highlight both the interactions between mGluR5 and NMDA receptors in the determination of schizophreniform behaviours and the potential for the effects of clozapine to be mediated by NMDA receptor regulation.
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Deletion of subunits of metabotropic glutamate receptors induces glutamatergic function deficits and schizophrenia-like symptoms.
“Deletion of subunits of metabotropic glutamate receptors induce glutamatergic function deficits 82,83 and schizophrenia-like symptoms.84,85”
From Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies (2013) · cites this paper as [82]
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Journal of Clinical Psychiatry
(2018) · Journal of Clinical Psychiatry · doi:10.5505/kpd · Cited by 13,703 · see citing works
A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Lindemann, L., Jaeschke, G., Michalon, A., Vieira, E., Honer, M., Spooren, W., Porter, R., Hartung, T., Kolczewski, S., Büttelmann, B., et al. (1909) · JAMA · doi:10.1001/jama.1909.02550020033007 · Cited by 7,865 · see citing works
Krystal, J. H. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030035004 · Cited by 3,330 · see citing works
The neuropathology of schizophrenia
Harrison, P. J. (1999) · Brain · doi:10.1093/brain/122.4.593 · Cited by 1,677 · see citing works
Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
Tu, J. C., Xiao, B., Naisbitt, S. R., Yuan, J. P., Petralia, R. S., Brakeman, P., Doan, A., Aakalu, V. K., Lanahan, A. A., Sheng, M., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80810-7 · Cited by 1,047 · see citing works
Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis
Coyle, J. T. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9062-8 · Cited by 917 · see citing works
Ionotropic and metabotropic glutamate receptor structure and pharmacology
Kew, J. N. C., & Kemp, J. A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2200-z · Cited by 792 · see citing works
Prefrontal neurons and the genetics of schizophrenia
Weinberger, D. R., Egan, M. F., Bertolino, A., Callicott, J. H., Mattay, V. S., Lipska, B. K., Berman, K. F., & Goldberg, T. E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01252-5 · Cited by 744 · see citing works
Keefe, R. S. E., Silva, S. G., Perkins, D. O., & Lieberman, J. A. (1999) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033374 · Cited by 690 · see citing works
Functional and Anatomical Aspects of Prefrontal Pathology in Schizophrenia
Goldman-Rakic, P. S., & Selemon, L. D. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.3.437 · Cited by 668 · see citing works
To Model a Psychiatric Disorder in Animals Schizophrenia As a Reality Test
Lipska, B. K. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00137-8 · Cited by 650 · see citing works
Lu, Y.-M., Jia, Z., Janus, C., Henderson, J. T., Gerlai, R., Wojtowicz, J. M., & Roder, J. C. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05196.1997 · Cited by 634 · see citing works
Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice
Chiamulera, C., Epping-Jordan, M. P., Zocchi, A., Marcon, C., Cottiny, C., Tacconi, S., Corsi, M., Orzi, F., & Conquet, F. (2001) · Nature Neuroscience · doi:10.1038/nn0901-873 · Cited by 554 · see citing works
Krystal, J. H., D'Souza, D. C., Mathalon, D., Perry, E., Belger, A., & Hoffman, R. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1582-z · Cited by 530 · see citing works
Glutamate as a therapeutic target in psychiatric disorders
Javitt, D. C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001551 · Cited by 524 · see citing works
Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex
Iwasato, T., Datwani, A., Wolf, A. M., Nishiyama, H., Taguchi, Y., Tonegawa, S., Knöpfel, T., Erzurumlu, R. S., & Itohara, S. (2000) · Nature · doi:10.1038/35021059 · Cited by 493 · see citing works
Awad, H., Hubert, G. W., Smith, Y., Levey, A. I., & Conn, P. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-07871.2000 · Cited by 423 · see citing works
Bringing Order to the Glutamate Chaos in Schizophrenia
Moghaddam, B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00757-8 · Cited by 403 · see citing works
Sarnyai, Z., Sibille, E. L., Pavlides, C., Fenster, R. J., McEwen, B. S., & Tóth, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14731 · Cited by 396 · see citing works
Ligand affinities at recombinant receptors depend on subunit composition
Laurie, D., & Seeburg, P. H. (1994) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(94)90058-2 · Cited by 386 · see citing works
Schizophrenia and Glutamatergic Transmission
Tamminga, C. A. (1998) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v12.i1-2.20 · Cited by 385 · see citing works
Adler, C. M., Malhotra, A. K., Elman, I., Goldberg, T. E., Egan, M. F., Pickar, D., & Breier, A. F. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.10.1646 · Cited by 337 · see citing works
Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment
Konradi, C., & Heckers, S. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00328-5 · Cited by 336 · see citing works
Burgen, A. S. V. (1971) · Nature · doi:10.1038/232587a0 · Cited by 329 · see citing works
Pisani, A., Gubellini, P., Bonsi, P., Conquet, F., Picconi, B., Centonze, D., Bernardi, G., & Calabresi, P. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00297-4 · Cited by 311 · see citing works
Modeling madness in mice: one piece at a time
Arguello, P. A., & Gogos, J. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.023 · Cited by 309 · see citing works
Kinney, G. G., O’Brien, J. A., Lemaire, W., Burno, M., Bickel, D. J., Clements, M. K., Chen, T., Wisnoski, D. D., Lindsley, C. W., Tiller, P. R., et al. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.079244 · Cited by 298 · see citing works
First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients
Pilowsky, L. S., Bressan, R. A., Stone, J. M., Erlandsson, K., Mulligan, R. S., Krystal, J. H., & Ell, P. J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001751 · Cited by 278 · see citing works
Homayoun, H., Stefani, M. R., Adams, B. W., Tamagan, G. D., & Moghaddam, B. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300417 · Cited by 252 · see citing works
Tissue Concentrations of Clozapine and its Metabolites in the Rat
Baldessarini, R. J., Centorrino, F., Flood, J. G., Volpicelli, S. A., Huston-Lyons, D., & Cohen, B. M. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.50 · Cited by 233 · see citing works
Selective Abolition of the NMDA Component of Long-Term Potentiation in Mice Lacking mGluR5Preprint
Jia, Z., Lu, Y., Henderson, J., Taverna, F. A., Romano, C., Abramow-Newerly, W., Wojtowicz, J. M., & Roder, J. (1998) · Learning & Memory · doi:10.1101/lm.5.4.331 · Cited by 233 · see citing works
Millan, M. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2199-1 · Cited by 226 · see citing works
Kinney, G. G., Burno, M., Campbell, U. C., Hernández, L. M., Rodriguez, D. E., Bristow, L. J., & Conn, P. J. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.048702 · Cited by 219 · see citing works
Rodrigues, S. M., Bauer, E. P., Farb, C. R., Schafe, G. E., & LeDoux, J. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05219.2002 · Cited by 215 · see citing works
PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex
Hannan, A. J., Blakemore, C. B., Katsnelson, A., Vitalis, T., Huber, K. M., Bear, M. F., Roder, J., Kim, D., Shin, H., & Kind, P. C. (2001) · Nature Neuroscience · doi:10.1038/85132 · Cited by 214 · see citing works
Self-citationOhnuma, T., Augood, S. J., Arai, H., McKenna, P. J., & Emson, P. C. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00063-1 · Cited by 210 · see citing works
Mccullumsmith, R., & Meador-Woodruff, J. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00370-0 · Cited by 189 · see citing works
Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn.
Bleakman, D., Rusin, K. I., Chard, P. S., et al. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08898-4 · Cited by 168 · see citing works
Arvanov, V. L., Liang, X., Schwartz, J. E., Grossman, S. D., & Wang, R. Y. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37013-2 · Cited by 162 · see citing works
Assessment of a prepulse inhibition deficit in a mutant mouse lacking mGlu5 receptors
Brody, S. A., Dulawa, S. C., Conquet, F., & Geyer, M. A. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001404 · Cited by 152 · see citing works
Dean, B., Crook, J. M., Opeskin, K., Hill, C., Keks, N. A., & Copolov, D. (1996) · PubMed · Cited by 149 · see citing works
Self-citationGupta, D. S., McCullumsmith, R. E., Beneyto, M., Haroutunian, V., Davis, K. L., & Meador‐Woodruff, J. H. (2005) · Synapse · doi:10.1002/syn.20164 · Cited by 146 · see citing works
Henry, S. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00332-5 · Cited by 145 · see citing works
Antipsychotic medication and cognitive function in schizophrenia
Hori, H., Noguchi, H., Hashimoto, R., Nakabayashi, T., Omori, M., Takahashi, S., Tsukue, R., Anami, K., Hirabayashi, N., Harada, S., et al. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.05.004 · Cited by 143 · see citing works
Hashimoto, K., Fujita, Y., Shimizu, E., et al. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.07.002 · Cited by 143 · see citing works
Yang, L., Mao, L., Tang, Q., Samdani, S., Liu, Z., & Wang, J. Q. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2496-04.2004 · Cited by 138 · see citing works
Abdul-Monim, Z., Reynolds, G. P., & Neill, J. C. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.01.019 · Cited by 136 · see citing works
Campbell, U. C., Lalwani, K., Hernández, L. M., Kinney, G. G., Conn, P. J., & Bristow, L. J. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1827-5 · Cited by 123 · see citing works
Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats
Balschun, D., & Wetzel, W. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00847-x · Cited by 116 · see citing works
Ballard, T. M., Woolley, M. L., Prinssen, E. P. M., Huwyler, J., Porter, R., & Spooren, W. P. J. M. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2211-9 · Cited by 110 · see citing works
Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats
Pietraszek, M., Sukhanov, I., Maciejak, P., Szyndler, J., Gravius, A., Wisłowska, A., Płaźnik, A., Bespalov, A., & Danysz, W. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.03.028 · Cited by 108 · see citing works
Importance of Animal Models in Schizophrenia Research
van den Buuse, M., Garner, B., Gogos, A., & Kusljic, S. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2005.01626.x · Cited by 105 · see citing works
Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site
Shim, S. S., Hammonds, M. D., & Kee, B. S. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0757-8 · Cited by 104 · see citing works
Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory
Balschun, D., Zuschratter, W., & Wetzel, W. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.043 · Cited by 94 · see citing works
Large, C. H. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107077712 · Cited by 94 · see citing works
Ohnuma, T., Tessler, S., Arai, H., et al. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00222-9 · Cited by 92 · see citing works
Bubeníková, V., Votava, M., Horáček, J., Páleníček, T., & Dockery, C. A. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.01.012 · Cited by 90 · see citing works
Barker, G. R. I., Bashir, Z. I., Brown, M. W., & Warburton, E. C. (2006) · Learning & Memory · doi:10.1101/lm.77806 · Cited by 88 · see citing works
Devon, R. S., Anderson, S. M., Teague, P., Muir, W. J., Murray, V., Pelosi, A. J., Blackwood, D., & Porteous, D. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000848 · Cited by 88 · see citing works
Mouse models for psychiatric disorders
Seong, E., Seasholtz, A. F., & Burmeister, M. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02807-x · Cited by 86 · see citing works
Pietraszek, M., Gravius, A., Schäfer, D., Weil, T., Trifanova, D., & Danysz, W. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.027 · Cited by 83 · see citing works
Koroś, E., Rosenbrock, H., Birk, G., Weiss, C., & Sams‐Dodd, F. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301133 · Cited by 82 · see citing works
A review of agitation in mental illness: burden of illness and underlying pathology.
Sachs, G. S. (2006) · PubMed · Cited by 81 · see citing works
Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality
Heresco‐Levy, U. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.007 · Cited by 80 · see citing works
Metabotropic glutamate receptors are involved in amygdaloid plasticity
Fendt, M., & Schmid, S. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01988.x · Cited by 80 · see citing works
Duncan, G. E., Moy, S. S., Lieberman, J. A., & Koller, B. H. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0214-1 · Cited by 78 · see citing works
The functional architecture of the prefrontal cortex and schizophrenia
Lewis, D. A., & Anderson, S. A. (1995) · Psychological Medicine · doi:10.1017/s0033291700037375 · Cited by 76 · see citing works
Molecular morphogens for dendritic spines
Ehlers, M. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02061-1 · Cited by 73 · see citing works
Cognitive effects of olanzapine and clozapine treatment in chronic schizophrenia
Sharma, T., Hughes, C., Soni, W., & Kumari, V. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1506-y · Cited by 72 · see citing works
Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics
Evins, A. E., Amico, E. T., Shih, V., & GOFF, D. C. (1997) · Journal of Neural Transmission · doi:10.1007/bf01291892 · Cited by 70 · see citing works
Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout mice
Brody, S. A., Conquet, F., & Geyer, M. A. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1635-3 · Cited by 69 · see citing works
Cortical Glutamatergic Markers in Schizophrenia
Scarr, E., Beneyto, M., Meador‐Woodruff, J. H., & Dean, B. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300758 · Cited by 67 · see citing works
Self-citationNMDA-induced phosphorylation and regulation of mGluR5
Alagarsamy, S., Rouse, S. T., Junge, C., et al. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00826-2 · Cited by 59 · see citing works
Ninan, I., Jardemark, K. E., & Wang, R. Y. (2003) · Synapse · doi:10.1002/syn.10189 · Cited by 56 · see citing works
Effects of mGlu1 and mGlu5 receptor antagonists on negatively reinforced learning
Gravius, A., Pietraszek, M., fer, D. S., Schmidt, W., & Danysz, W. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200503000-00007 · Cited by 54 · see citing works
Kendrick, S. J., Lynch, D. R., & Pritchett, D. B. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67020608.x · Cited by 53 · see citing works
Bordi, F., Marcon, C., Chiamulera, C., & Reggiani, A. M. (1996) · Neuropharmacology · doi:10.1016/s0028-3908(96)00101-3 · Cited by 52 · see citing works
Focus on Childhood and Adolescent Mental Health
DelBello, M. P. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0101 · Cited by 45 · see citing works
Gene targeting reveals a role for the glutamate receptors mGluR5 and GluR2 in learning and memory
Jia, Z., Lu, Y. M., Agopyan, N., & Roder, J. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00516-9 · Cited by 43 · see citing works
Mao, L., & Wang, J. Q. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00400-1 · Cited by 42 · see citing works
Grottick, A. J., Bagnol, D., Phillips, S., McDonald, J., Behan, D. P., Chalmers, D. T., & Hakak, Y. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.05.020 · Cited by 42 · see citing works
Levin, E. D., & Christopher, N. C. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.10.018 · Cited by 38 · see citing works
Levin, E. D., Petro, A. E., & Caldwell, D. P. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.01.012 · Cited by 37 · see citing works
Pietraszek, M., Rogóż, Z., Wolfarth, S., & Ossowska, K. (2004) · PubMed · Cited by 30 · see citing works
van den Buuse, M., Martin, S., Brosda, J., Leck, K. J., MATTHAEI, K. I., & Hendry, I. A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0181-6 · Cited by 28 · see citing works
Giardino, L., Bortolotti, F., Orazzo, C., Pozza, M., Monteleone, P., Calzà, L., & Maj, M. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00478-2 · Cited by 27 · see citing works
The effects of clozapine on delayed spatial alternation deficits in rats with hippocampal damage
Bardgett, M. E., Griffith, M. S., Foltz, R. F., Hopkins, J. A., Massie, C. M., & O’Connell, S. M. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.08.010 · Cited by 21 · see citing works
Studies on serotonergic markers in the human hippocampus: changes in subjects with bipolar disorder
Dean, B., Scarr, E., Pavey, G., & Copolov, D. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00021-6 · Cited by 20 · see citing works
Self-citationProtein Binding of Piroxicam Studied by Means of Affinity Chromatography and Circular Dichroism
Russeva, V. N., Zhivkova, Z. D., Prodanova, K., et al. (1999) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357991772088 · Cited by 19 · see citing works
Clinical perspectives on atypical antipsychotics for treatment of agitation.
Caine, E. D. (2006) · PubMed · Cited by 14 · see citing works
Importance of animal models in schizophrenia research
van den Buuse, M., Garner, B., Gogos, A., et al. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1111/j.1440-1614.2005.01626.x · Cited by 13 · see citing works
Ossowska, K., Pietraszek, M., Wardas, J., et al. (1999) · PubMed · Cited by 7 · see citing works
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Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies
Marsman, A., van den Heuvel, M. P., Klomp, D. W. J., Kahn, R. S., Luijten, P. R., & Hulshoff Pol, H. E. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr069 · Cited by 457 · see citing works
Sani, G., Serra, G., Kotzalidis, G. D., Romano, S., Tamorri, S. M., Manfredi, G., Caloro, M., Telesforo, C. L., Caltagirone, S. S., Panaccione, I., et al. (2012) · CNS Drugs · doi:10.2165/11634390-000000000-00000 · Cited by 273 · see citing works
Glutamatergic model psychoses: prediction error, learning, and inference
Corlett, P. R., Honey, G. D., Krystal, J. H., & Fletcher, P. C. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.163 · Cited by 229 · see citing works
Prepulse inhibition and genetic mouse models of schizophrenia
Powell, S. B., Zhou, X., & Geyer, M. A. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.021 · Cited by 218 · see citing works
Carlisle, H. J., Luong, T. N., Medina-Marino, A., Schenker, L., Khorosheva, E., Indersmitten, T., Gunapala, K. M., Steele, A. D., O'Dell, T. J., Patterson, P. H., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5877-10.2011 · Cited by 74 · see citing works
- Authors
- Gray, L., van den Buuse, M., Scarr, E., Dean, B., & Hannan, A. J.
- Affiliations
- The University of Melbourne (AU)
- Mental Health Research Institute (AU)
- Corresponding author
- Gray, Laura
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-07-02
- Volume
- 12
- Issue
- 01
- Pages
- 45
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2114342445
- Cited by
- 130
- References
- 92
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 4 · 2021: 3 · 2020: 11 · 2019: 13 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 9 · 2014: 8 · 2013: 6 · 2012: 15
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- clozapine, schizophrenia, metabotropic glutamate receptor 5, NMDA receptor, MK-801, prepulse inhibition, locomotor hyperactivity, spatial memory, glutamatergic signalling, receptor binding
- MeSH terms
- Animals, Autoradiography, Behavior, Animal, Benzamides, Clozapine, Exploratory Behavior, Mice, Inbred C57BL, Motor Activity, Radioligand Assay, Schizophrenia, Schizophrenic Psychology, Serotonin Antagonists, Reflex, Startle, Antipsychotic Agents, Up-Regulation, Receptors, N-Methyl-D-Aspartate, Receptors, Metabotropic Glutamate, Mice, Knockout, Excitatory Amino Acid Antagonists, Muscarinic Antagonists, Mice, Receptor, Metabotropic Glutamate 5
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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