NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development

Krystal, John H.; D'Souza, D. Cyril; Mathalon, Daniel; Perry, Edward; Belger, Aysenil; Hoffman, Ralph

doi:10.1007/s00213-003-1582-z

Cited by 530Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchTreatment of Major Depression

NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development

Open access

Krystal, John H., D'Souza, D. Cyril, Mathalon, Daniel, Perry, Edward, Belger, Aysenil, Hoffman, Ralph·2003·Psychopharmacology

DOI 10.1007/s00213-003-1582-z

Open this paper in CoChat — free account

Abstract

There is an urgent need to improve the pharmacotherapy of schizophrenia despite the introduction of important new medications. New treatment insights may come from appreciating the therapeutic implications of model psychoses. In particular, basic and clinical studies have employed the N-methyl-D-aspartate (NMDA) glutamate receptor antagonist, ketamine, as a probe of NMDA receptor contributions to cognition and behavior. These studies illustrate a translational neuroscience approach for probing mechanistic hypotheses related to the neurobiology and treatment of schizophrenia and other disorders. Two particular pathophysiologic themes associated with schizophrenia, the disturbance of cortical connectivity and the disinhibition of glutamatergic activity may be modeled by the administration of NMDA receptor antagonists. The purpose of this review is to consider the possibility that agents that attenuate these two components of NMDA receptor antagonist response may play complementary roles in the treatment of schizophrenia.

Integrity signals

Registry

Crossref · 10.1007/s00213-003-1582-z

Cites

308 of 308 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

As a pharmacological model of schizophrenia, ketamine allows for controlled and transient NMDAR manipulation in healthy volunteers.
“As a pharmacological model of schizophrenia, ketamine allows for controlled and transient NMDAR manipulation in healthy volunteers (Krystal et al. 2003).”
From Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model (2014) · cites this paper as Krystal et al. 2003

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Clozapine for the Treatment-Resistant Schizophrenic: A Double-blind Comparison With Chlorpromazine
Kane, J. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800330013001 · Cited by 4,156 · see citing works
Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans: Psychotomimetic, Perceptual, Cognitive, and Neuroendocrine Responses
Krystal, J. H. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030035004 · Cited by 3,330 · see citing works
Self-citation
Glycine potentiates the NMDA response in cultured mouse brain neurons
Johnson, J. W., & Ascher, P. (1987) · Nature · doi:10.1038/325529a0 · Cited by 3,151 · see citing works
PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS
Conn, P. J., & Pin, J. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.205 · Cited by 3,083 · see citing works
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020020004 · Cited by 2,019 · see citing works
Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793 · see citing works
Glutamate receptor dysfunction and schizophrenia
Olney, J. W. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240016004 · Cited by 1,685 · see citing works
Neuregulin 1 and Susceptibility to Schizophrenia
Stefánsson, H., Pétursson, H., Sigurðsson, E., Steinthórsdóttir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342734 · Cited by 1,671 · see citing works
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636 · see citing works
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525 · see citing works
Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477 · see citing works
The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate
Anis, N. A., Berry, S. C., Burton, N. R., & Lodge, D. (1983) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1983.tb11031.x · Cited by 1,399 · see citing works
Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.
Meltzer, H. Y., Matsubara, S., & Lee, J. C. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20710-8 · Cited by 1,352 · see citing works
Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects
Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., D'Souza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9235 · Cited by 1,291 · see citing works
Self-citation
THE BRAIN’S RECORD OF AUDITORY AND VISUAL EXPERIENCE: A FINAL SUMMARY AND DISCUSSION
PENFIELD, W., & PEROT, P. (1963) · Brain · doi:10.1093/brain/86.4.595 · Cited by 1,230 · see citing works
Risperidone in the treatment of schizophrenia
Marder, S. R., & Meibach, R. C. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.6.825 · Cited by 1,194 · see citing works
Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia
Hakak, Y., Walker, J. R., Li, C., Wong, W. H., Davis, K. L., Buxbaum, J. D., Haroutunian, V., & Fienberg, A. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081071198 · Cited by 1,192 · see citing works
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method
Breier, A., Su, T.-P., Saunders, R., Carson, R. E., Kolachana, B. S., de Bartolomeis, A., Weinberger, D. R., Weisenfeld, N., Malhotra, A. K., Eckelman, W. C., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2569 · Cited by 1,154 · cited 2× · see citing works
“In schizophrenic patients, particularly those with recent psychotic exacerbations, psy- chotic symptoms are associated with dopaminergic hyperactivity (Abi-Dargham et al. 2000; Breier et al. 1997b; Laruelle et al. 1996, 1999).”
BackgroundInfluential
Experience-Induced Neurogenesis in the Senescent Dentate Gyrus
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03206.1998 · Cited by 1,150 · see citing works
Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia
Saykin, A. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020048005 · Cited by 1,086 · see citing works
GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder
Benes, F. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00225-1 · Cited by 1,082 · see citing works
Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors
Kramer, M. S., Cutler, N. R., Feighner, J. P., Shrivastava, R. K., Carman, J. S., Sramek, J. J., Reines, S. A., Liu, G. F., Snavely, D. B., Wyatt-Knowles, E. S., et al. (1998) · Science · doi:10.1126/science.281.5383.1640 · Cited by 1,071 · see citing works
Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
Tu, J. C., Xiao, B., Naisbitt, S. R., Yuan, J. P., Petralia, R. S., Brakeman, P., Doan, A., Aakalu, V. K., Lanahan, A. A., Sheng, M., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80810-7 · Cited by 1,047 · see citing works
Increased baseline occupancy of D 2 receptors by dopamine in schizophrenia
Abi-Dargham, A., Rodenhiser, J., Printz, D., Zea-Ponce, Y., Gil, R., Kegeles, L. S., Weiss, R., Cooper, T. B., Mann, J. J., Van Heertum, R. L., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.8104 · Cited by 1,020 · see citing works
Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats
Moghaddam, B., & Adams, B. W. (1998) · Science · doi:10.1126/science.281.5381.1349 · Cited by 1,006 · see citing works
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002 · see citing works
Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors
Burris, K. D., Molski, T. F. P., Xu, C., Ryan, E., Tottori, K., Kikuchi, T., Yocca, F. D., & Molinoff, P. B. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.033175 · Cited by 924 · see citing works
Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia
Lahti, A. C., Koffel, B., LaPorte, D. J., & Tamminga, C. A. (1995) · Neuropsychopharmacology · doi:10.1016/0893-133x(94)00131-i · Cited by 921 · see citing works
Study of a New Schizophrenomimetic Drug—Sernyl
LUBY, E. D. (1959) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1959.02340150095011 · Cited by 921 · see citing works
The reduced neuropil hypothesis: a circuit based model of schizophrenia
Selemon, L. D., & Goldman-Rakic, P. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00281-9 · Cited by 909 · see citing works
A functional neuroanatomy of hallucinations in schizophrenia
Silbersweig, D. A., Stern, E., Frith, C., Cahill, C., Holmes, A., Grootoonk, S., Seaward, J., McKenna, P., Chua, S. E., Schnorr, L., et al. (1995) · Nature · doi:10.1038/378176a0 · Cited by 906 · cited 1× · see citing works
“…with direct electrical stimulation of brain regions associated with the auditory function (Gloor 1990; Halgren et al. 1978; Penfield and Perot 1963) and the regional cortical activation patterns during auditory hallucinations (Dierks et al. 1999; Silbersweig et al. 1995; Shergill et al. 2000).”
Background
Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients
Benes, F. M. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810350036005 · Cited by 894 · see citing works
Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory
Wang, X.-J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09587.1999 · Cited by 859 · see citing works
D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release
Schell, M. J., Molliver, M. E., & Snyder, S. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3948 · Cited by 832 · see citing works
Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia
Thompson, P. M., Vidal, C., Giedd, J. N., Gochman, P., Blumenthal, J., Nicolson, R., Toga, A. W., & Rapoport, J. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201243998 · Cited by 812 · see citing works
Multiple fixed doses of “Seroquel” (quetiapine) in patients with acute exacerbation of schizophrenia: A comparison with haloperidol and placebo
Arvanitis, L. A., & Miller, B. G. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00190-x · Cited by 806 · see citing works
Pharmacologic effects of CI‐581, a new dissociative anesthetic, in man
Domino, E. F., Chodoff, P., & Corssen, G. (1965) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt196563279 · Cited by 753 · see citing works
A decrease of reelin expression as a putative vulnerability factor in schizophrenia
Impagnatiello, F., Guidotti, A. R., Pesold, C., Dwivedi, Y., Caruncho, H. J., Pisu, M. G., Uzunov, D. P., Smalheiser, N. R., Davis, J. M., Pandey, G. N., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15718 · Cited by 753 · see citing works
Activation of Heschl’s Gyrus during Auditory Hallucinations
Dierks, T., Linden, D. E. J., Jandl, M., Formisano, E., Goebel, R., Lanfermann, H., & Singer, W. (1999) · Neuron · doi:10.1016/s0896-6273(00)80715-1 · Cited by 752 · see citing works
Increased dopamine transmission in schizophrenia: relationship to illness phases.
Laruelle, M., Abi-Dargham, A., Gil, R. B., Kegeles, L., & Innis, R. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00067-0 · Cited by 744 · see citing works
Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective
Young, D., Lawlor, P. A., Leone, P., Dragunow, M., & During, M. J. (1999) · Nature Medicine · doi:10.1038/7449 · Cited by 731 · see citing works
Clinical and Theoretical Implications of 5-HT2 and D2 Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia
Kapur, S., Zipursky, R. B., & Remington, G. J. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.286 · Cited by 711 · see citing works
Ketamine: an update on the first twenty-five years of clinical experience
Reich, D. L., & Silvay, G. (1989) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03011442 · Cited by 707 · see citing works
Decreased Glutamic Acid Decarboxylase67 Messenger RNA Expression in a Subset of Prefrontal Cortical γ-Aminobutyric Acid Neurons in Subjects With Schizophrenia
Volk, D. W., Austin, M. C., Pierri, J. N., Sampson, A. R., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.3.237 · Cited by 697 · see citing works
Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System
Schoepp, D. D. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29296-x · Cited by 693 · see citing works
Ketamine-Induced Exacerbation of Psychotic Symptoms and Cognitive Impairment in Neuroleptic-Free Schizophrenics
Malhotra, A. K. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00036-5 · Cited by 681 · see citing works
Altered Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Cells in Frontal Lobe of Schizophrenics Implies Disturbances of Cortical Development
Akbarian, S. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820150007001 · Cited by 679 · see citing works
D-Alanine Added to Antipsychotics for the Treatment of Schizophrenia
Tsai, G. E., Yang, P., Chang, Y., & Chong, M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.032 · Cited by 676 · see citing works
Effects of Ketamine in Normal and Schizophrenic Volunteers
Lahti, A. C. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00243-3 · Cited by 674 · see citing works
Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins
Weinberger, D. R., Berman, K. F., Suddath, R. L., & Torrey, E. F. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.7.890 · Cited by 666 · see citing works
Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging
Shergill, S. S., Brammer, M. J., Williams, S. C. R., Murray, R. M., & McGuire, P. K. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.11.1033 · Cited by 666 · cited 3× · see citing works
“Even when patients as a group had normal or reduced metabolism, metabolic rates increased with increasing severity of positive symptoms (Gur et al. 1987), particularly auditory hallucinations (Dierks et al. 1999; Shergill et al. 2000).”
Background
Gamma frequency-range abnormalities to auditory stimulation in schizophrenia
Kwon, J. S., O'Donnell, B. F., Wallenstein, G. V., Greene, R. W., Hirayasu, Y., Nestor, P. G., Hasselmo, M. E., Potts, G. F., Shenton, M. E., & McCarley, R. W. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.11.1001 · Cited by 654 · see citing works
Efficacy and Safety of Aripiprazole and Haloperidol Versus Placebo in Patients With Schizophrenia and Schizoaffective Disorder
Kane, J. M., Carson, W. H., Saha, A. R., McQuade, R. D., Ingenito, G. G., ZIMBROFF, D. L., & Ali, M. W. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0903 · Cited by 624 · see citing works
Selective Deficits in Prefrontal Cortex Function in Medication-Naive Patients With Schizophrenia
Barch, D. M., Carter, C. S., Braver, T. S., Sabb, F. W., MacDonald, A. W., Noll, D. C., & Cohen, J. D. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.3.280 · Cited by 615 · see citing works
Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo
Quinlan, E., Philpot, B. D., Huganir, R., & Bear, M. (1999) · Nature Neuroscience · doi:10.1038/7263 · Cited by 614 · see citing works
Ketamine-Induced NMDA Receptor Hypofunction as a Model of Memory Impairment and Psychosis
Newcomer, J. W. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00067-0 · Cited by 604 · see citing works
Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naïve patients
Andreasen, N. C., OʼLeary, D. S., Flaum, M. A., Nopoulos, P., Watkins, G. L., Ponto, L. L. B., & Hichwa, R. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)08258-x · Cited by 597 · see citing works
Increased cortical kynurenate content in schizophrenia
Schwarcz, R., Rassoulpour, A., Wu, H.-Q., Medoff, D., Tamminga, C. A., & Roberts, R. C. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01078-2 · Cited by 590 · see citing works
Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients
Speer, A. M., Kimbrell, T. A., Wassermann, E. M., Repella, J. D., Willis, M. W., Herscovitch, P., & Post, R. M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01065-9 · Cited by 587 · see citing works
A neurohistological correlate of schizophrenia.
Kovelman, J. A., & Scheibel, A. B. (1984) · PubMed · Cited by 582 · see citing works
MENTAL PHENOMENA EVOKED BY ELECTRICAL STIMULATION OF THE HUMAN HIPPOCAMPAL FORMATION AND AMYGDALA
Halgren, E., WALTER, R. D., Cherlow, D. G., & Crandall, P. H. (1978) · Brain · doi:10.1093/brain/101.1.83 · Cited by 573 · see citing works
D-serine added to antipsychotics for the treatment of schizophrenia
Tsai, G. E., Yang, P., Chung, L.-C., LANGE, N. D., & Coyle, J. T. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00279-0 · Cited by 572 · see citing works
The Glutamatergic Dysfunction Hypothesis for Schizophrenia
Coyle, J. T. (1996) · Harvard Review of Psychiatry · doi:10.3109/10673229609017192 · Cited by 568 · see citing works
Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments
Krystal, J. H., Sanacora, G., Blumberg, H., Anand, A., Charney, D. S., Marek, G., Epperson, C. N., Goddard, A., & Mason, G. F. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001021 · Cited by 553 · see citing works
Self-citation
Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia
Chumakov, I., Blumenfeld, M., Guerassimenko, O., Cavarec, L., Palicio, M., Abderrahim, H., Bougueleret, L., Barry, C., Tanaka, H., Rosa, P. L., et al. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.182412499 · Cited by 541 · see citing works
Neuronal and Glial Somal Size in the Prefrontal Cortex: A Postmortem Morphometric Study of Schizophrenia and Huntington Disease
Rajkowska, G., Selemon, L. D., & Goldman-Rakic, P. S. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.3.215 · Cited by 537 · see citing works
Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations
Lawrie, S. M., Buechel, C., Whalley, H. C., Frith, C. D., Friston, K. J., & Johnstone, E. C. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01316-1 · Cited by 529 · see citing works
Transcranial Magnetic Stimulation of Left Temporoparietal Cortex and Medication-Resistant Auditory Hallucinations
Hoffman, R. E., Hawkins, K. A., Gueorguieva, R. V., Boutros, N. N., Rachid, F., Carroll, K. M., & Krystal, J. H. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.1.49 · Cited by 517 · see citing works
Self-citation
A Comparison of Clozapine and Haloperidol in Hospitalized Patients with Refractory Schizophrenia
Rosenheck, R. A., Cramer, J. A., Xu, W., Thomas, J. V., Henderson, W., Frisman, L. K., Fye, C. L., & Charney, D. S. (1997) · New England Journal of Medicine · doi:10.1056/nejm199709183371202 · Cited by 516 · see citing works
The Relation between Funding by the National Institutes of Health and the Burden of Disease
Gross, C. P., Anderson, G. F., & Powe, N. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906173402406 · Cited by 509 · see citing works
Evidence for Abnormal Cortical Functional Connectivity During Working Memory in Schizophrenia
Meyer‐Lindenberg, A., Poline, J., Kohn, P. D., Holt, J. L., Egan, M. F., Weinberger, D. R., & Berman, K. F. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1809 · Cited by 507 · see citing works
The anatomy of conscious vision: an fMRI study of visual hallucinations
Ffytche, D. H., Howard, R. J., Brammer, M. J., David, A. S., Woodruff, P. W. R., & Williams, S. (1998) · Nature Neuroscience · doi:10.1038/3738 · Cited by 504 · see citing works
Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage
Werner, P., Pitt, D., & Raine, C. S. (2001) · Annals of Neurology · doi:10.1002/ana.1077 · Cited by 489 · see citing works
Efficacy of High-Dose Glycine in the Treatment of Enduring Negative Symptoms of Schizophrenia
Heresco‐Levy, U., Javitt, D. C., Ermilov, M., Mordel, C., Silipo, G. S., & Lichtenstein, M. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.1.29 · Cited by 487 · see citing works
NMDA-dependent modulation of CA1 local circuit inhibition
Grunze, H., Rainnie, D., Hasselmo, M., Barkai, E., Hearn, E., McCarley, R., & Greene, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02034.1996 · Cited by 467 · see citing works
Distorted Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Neurons in Temporal Lobe of Schizophrenics Implies Anomalous Cortical Development
Akbarian, S. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820150016002 · Cited by 456 · see citing works
Abnormal Excitatory Neurotransmitter Metabolism in Schizophrenic Brains
Tsai, G. E. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950220039008 · Cited by 455 · see citing works
Uncinate Fasciculus Findings in Schizophrenia: A Magnetic Resonance Diffusion Tensor Imaging Study
Kubicki, M. R., Westin, C., Maier, S. E., Frumin, M., Nestor, P. G., Salisbury, D. F., Kikinis, R., Jolesz, F. A., McCarley, R. W., & Shenton, M. E. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.813 · Cited by 454 · see citing works
Compromised White Matter Tract Integrity in Schizophrenia Inferred From Diffusion Tensor Imaging
Lim, K. O., Hedehus, M., Moseley, M. E., de Crespigny, A. J., Sullivan, E. V., & Pfefferbaum, A. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.4.367 · Cited by 447 · see citing works
A role for NMDA-receptor channels in working memory
Lisman, J. E., Fellous, J., & Wang, X. (1998) · Nature Neuroscience · doi:10.1038/1086 · Cited by 438 · see citing works
A Placebo-Controlled Trial of D-Cycloserine Added to Conventional Neuroleptics in Patients With Schizophrenia
GOFF, D. C., Tsai, G. E., Levitt, J. J., AMICO, E. T., Manoach, D. S., Schoenfeld, D., Hayden, D. L., McCarley, R. W., & Coyle, J. T. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.1.21 · Cited by 436 · see citing works
Ketamine activates psychosis and alters limbic blood flow in schizophrenia
Lahti, A. C., Holcomb, H. H., Medoff, D. R., & Tamminga, C. A. (1995) · Neuroreport · doi:10.1097/00001756-199504190-00011 · Cited by 434 · see citing works
Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.
Øye, I., Paulsen, O., & Maurset, A. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11430-4 · Cited by 434 · see citing works
Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics
BEASLEY, C., & REYNOLDS, G. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00122-3 · Cited by 426 · see citing works
Attenuation of the Neuropsychiatric Effects of Ketamine With Lamotrigine: Support for Hyperglutamatergic Effects ofN-methyl-D-aspartate Receptor Antagonists
Anand, A., Charney, D. S., Oren, D. A., Berman, R. M., Hu, X. S., Cappiello, A., & Krystal, J. H. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.3.270 · Cited by 426 · see citing works
Self-citation
Activation of Metabotropic Glutamate Receptor 5 Has Direct Excitatory Effects and Potentiates NMDA Receptor Currents in Neurons of the Subthalamic Nucleus
Awad, H., Hubert, G. W., Smith, Y., Levey, A. I., & Conn, P. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-07871.2000 · Cited by 423 · see citing works
Expression Mechanisms Underlying NMDA Receptor‐Dependent Long‐Term Potentiation
Nicoll, R., & Malenka, R. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11320.x · Cited by 417 · see citing works
d-Serine as a Neuromodulator: Regional and Developmental Localizations in Rat Brain Glia Resemble NMDA Receptors
Schell, M. J., Brady Jr., R. O., Molliver, M. E., & Snyder, S. H. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01604.1997 · Cited by 415 · cited 2× · see citing works
“…another endogenous glycineB receptor agonist, dserine, to enhance NMDA receptor function in an activity-dependent manner (Ivanovic et al. 1998; Schell et al. 1997). d-Serine may be released into synapses by glia in response to a-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) glutamate…”
Background
Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)- and (R)-ketamine in healthy volunteers using positron emission tomography (PET)
Vollenweider, F. X., Leenders, K. L., Øye, I., Hell, D., & Angst, J. (1997) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(96)00042-9 · Cited by 413 · see citing works
Glutamate receptor expression in schizophrenic brain
Meador‐Woodruff, J. H. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00044-2 · Cited by 412 · see citing works
Modulation of N -methyl- d -aspartate receptor function by glycine transport
Bergeron, R., Meyer, T. M., Coyle, J. T., & Greene, R. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15730 · Cited by 412 · see citing works
Intramuscular Ketamine for Pediatric Sedation in the Emergency Department: Safety Profile in 1,022 Cases
Green, S. M., Rothrock, S. G., Lynch, E. L., Ho, M., Harris, T., Hestdalen, R., Hopkins, G. A., Garrett, W., & Westcott, K. (1998) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(98)70226-4 · Cited by 409 · see citing works
Destruction and Creation of Spatial Tuning by Disinhibition: GABAABlockade of Prefrontal Cortical Neurons Engaged by Working Memory
Rao, S. G., Williams, G. V., & Goldman-Rakic, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00485.2000 · Cited by 407 · see citing works
Maldistribution of Interstitial Neurons in Prefrontal White Matter of the Brains of Schizophrenic Patients
Akbarian, S. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830050061010 · Cited by 398 · see citing works
Does risperidone improve verbal working memory in treatment-resistant schizophrenia?
Green, M. F., Marshall, B. D., Wirshing, W. C., Ames, D., Marder, S. R., McGurk, S. R., Kern, R. S., & Mintz, J. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.6.799 · Cited by 397 · see citing works
Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1α, mGluR2 and mGluR5, relative to neurotransmitter release sites
Luján, R., Roberts, J. D. B., Shigemoto, R., Ohishi, H., & Somogyi, P. (1997) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(97)00051-3 · Cited by 395 · see citing works
Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.6.805 · Cited by 392 · see citing works
Schizophrenia and Glutamatergic Transmission
Tamminga, C. A. (1998) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v12.i1-2.20 · Cited by 385 · see citing works
EXPERIENTIAL PHENOMENA OF TEMPORAL LOBE EPILEPSY
GLOOR, P. (1990) · Brain · doi:10.1093/brain/113.6.1673 · Cited by 376 · see citing works
Ziprasidone 80 mg/day and 160 mg/day in the Acute Exacerbation of Schizophrenia and Schizoaffective Disorder A 6-Week Placebo-Controlled Trial
Daniel, D. G. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00090-6 · Cited by 376 · see citing works
Dopamine D1 Receptor-Dependent Trafficking of Striatal NMDA Glutamate Receptors to the Postsynaptic Membrane
Dunah, A. W., & Standaert, D. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05546.2001 · Cited by 374 · see citing works
Psychedelic Effects of Ketamine in Healthy Volunteers
Bowdle, A. T., Radant, A. D., Cowley, D. S., Kharasch, E. D., Strassman, R. J., & Roy‐Byrne, P. (1998) · Anesthesiology · doi:10.1097/00000542-199801000-00015 · Cited by 370 · see citing works
MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia
Buchsbaum, M., Tang, C. Y., Peled, S., Gudbjartsson, H., Lu, D.-F., Hazlett, E., Downhill, J., Haznedar, M., Fallon, J., & Atlas, S. (1998) · NeuroReport · doi:10.1097/00001756-199802160-00013 · Cited by 369 · see citing works
Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics
Benes, F., Vincent, S. L., Alsterberg, G., Bird, E. D., & SanGiovanni, J. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00924.1992 · Cited by 367 · see citing works
Amelioration of negative symptoms in schizophrenia by glycine
Javitt, D. C., Zylberman, I., Zukin, S. R., Heresco‐Levy, U., & Lindenmayer, J. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.8.1234 · Cited by 353 · see citing works
Neurocognitive Enhancement Therapy With Work Therapy
Bell, M. D., BRYSON, G. J., Greig, T. C., Corcoran, C., & Wexler, B. E. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.8.763 · Cited by 352 · see citing works
A systems model of altered consciousness: integrating natural and drug-induced psychoses
Vollenweider, F. X., & Geyer, M. A. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00646-3 · Cited by 339 · see citing works
Natural History of Schizophrenia Subtypes
Fenton, W. S. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810350018003 · Cited by 338 · see citing works
Symptoms, Cognitive Functioning, and Adaptive Skills in Geriatric Patients With Lifelong Schizophrenia: A Comparison Across Treatment Sites
Harvey, P. D., Howanitz, E. M., Parrella, M. J., WHITE, L. E., Davidson, M., Mohs, R. C., Hoblyn, J. C., & Davis, K. L. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.8.1080 · Cited by 337 · see citing works
Isodirectional Tuning of Adjacent Interneurons and Pyramidal Cells During Working Memory: Evidence for Microcolumnar Organization in PFC
Rao, S. G., Williams, G. V., & Goldman, P. S. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.4.1903 · Cited by 335 · see citing works
Reduced communication between frontal and temporal lobes during talking in schizophrenia
Ford, J. M., Mathalon, D. H., Whitfield‐Gabrieli, S., Faustman, W. O., & Roth, W. T. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01335-x · Cited by 332 · see citing works
Self-citation
Differential effects of enrichment on learning and memory function in NR2B transgenic mice
Tang, Y., Wang, H., Feng, R., Kyin, M., & Tsien, J. Z. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00122-8 · Cited by 330 · see citing works
Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia. Regional and diagnostic specificity.
Glantz, L., & Lewis, D. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830220065010 · Cited by 328 · see citing works
A Dopamine/D1 Receptor/Protein Kinase A/Dopamine- and cAMP-Regulated Phosphoprotein (Mr32 kDa)/Protein Phosphatase-1 Pathway Regulates Dephosphorylation of the NMDA Receptor
Snyder, G. L., Fienberg, A. A., Huganir, R. L., & Greengard, P. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10297.1998 · Cited by 327 · see citing works
Trait and state aspects of p300 amplitude reduction in schizophrenia: a retrospective longitudinal study
Mathalon, D. H., Ford, J. M., & Pfefferbaum, A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00277-2 · Cited by 315 · see citing works
Self-citation
N-methyl-d-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability
Krystal, J. H., Petrakis, I. L., Mason, G. F., Trevisan, L. A., & D’Souza, D. C. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00054-8 · Cited by 313 · see citing works
Self-citation
Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions
Arnold, S. E., Franz, B. R., Gur, R. C., Gur, R. E., Shapiro, R. M., Moberg, P. J., & Trojanowski, J. Q. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.5.738 · Cited by 309 · see citing works
Negative symptoms: a path analytic approach to a double-blind, placebo- and haloperidol-controlled clinical trial with olanzapine
Tollefson, G. D., & Sanger, T. M. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.4.466 · Cited by 306 · see citing works
KETAMINE INFUSIONS: PHARMACOKINETICS AND CLINICAL EFFECTS
Idvall, J., Ahlgren, I., Aronsen, K. F., & Stenberg, P. B. (1979) · British Journal of Anaesthesia · doi:10.1093/bja/51.12.1167 · Cited by 306 · see citing works
Controlled, dose-response study of sertindole and haloperidol in the treatment of schizophrenia. Sertindole Study Group
ZIMBROFF, D. L., Kane, J. M., Tamminga, C. A., Daniel, D. G., Mack, R. J., Wozniak, P. J., Sebree, T. B., Wallin, B., & Kashkin, K. B. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.6.782 · Cited by 306 · see citing works
Neurophysiological evidence of corollary discharge dysfunction in schizophrenia
Ford, J. M., Mathalon, D. H., Heinks, T., Kalba, S., Faustman, W. O., & Roth, W. T. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.2069 · Cited by 304 · see citing works
Self-citation
Severity of symptoms in chronically institutionalized geriatric schizophrenic patients
Davidson, M., Harvey, P. D., Powchik, P., Parrella, M., WHITE, L. E., Knobler, H. Y., LOSONCZY, M. F., Keefe, R. S. E., Katz, S., & Frecska, E. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.2.197 · Cited by 303 · see citing works
Alterations in Chandelier Neuron Axon Terminals in the Prefrontal Cortex of Schizophrenic Subjects
Pierri, J. N., Chaudry, A. S., Woo, T.-U. W., & Lewis, D. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1709 · Cited by 294 · see citing works
Mechanisms of Calcium Influx into Hippocampal Spines: Heterogeneity among Spines, Coincidence Detection by NMDA Receptors, and Optical Quantal Analysis
Yuste, R., Majewska, A. K., Cash, S. S., & Denk, W. T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-01976.1999 · Cited by 288 · see citing works
Slow Transcranial Magnetic Stimulation, Long-Term Depotentiation, and Brain Hyperexcitability Disorders
Hoffman, R. E., & Çavuş, I. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1093 · Cited by 286 · see citing works
Self-citation
Cognitive Correlates of Job Tenure Among Patients With Severe Mental Illness
Gold, J. M., Goldberg, R. W., McNary, S. W., Dixon, L. B., & Lehman, A. F. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.8.1395 · Cited by 285 · see citing works
What Are the Right Targets for Psychopharmacology?
Hyman, S. E., & Fenton, W. S. (2003) · Science · doi:10.1126/science.1077141 · Cited by 282 · see citing works
The comparative efficacy and long-term effect of clozapine treatment on neuropsychological test performance
Buchanan, R. W., Holstein, C., & Breier, A. F. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90082-5 · Cited by 281 · see citing works
Up-regulation of GABAA receptor binding on neurons of the prefrontal cortex in schizophrenic subjects
Benes, F. M., Vincent, S. L., Marie, A. S., & Khan, Y. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00328-4 · Cited by 274 · see citing works
Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects
Krystal, J. H., Abi-Saab, W., Perry, E., D’Souza, D. C., Liu, N., Gueorguieva, R., McDougall, L., Hunsberger, T., Belger, A., Levine, L., et al. (2005) · Psychopharmacology · doi:10.1007/s00213-004-1982-8 · Cited by 272 · see citing works
Self-citation
Reciprocal Alterations in Pre- and Postsynaptic Inhibitory Markers at Chandelier Cell Inputs to Pyramidal Neurons in Schizophrenia
Volk, D. W. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.10.1063 · Cited by 264 · see citing works
Design, Synthesis, and Biological Activity of a Potent Inhibitor of the Neuropeptidase N-Acetylated α-Linked Acidic Dipeptidase
Jackson, P., Cole, D. C., Slusher, B. S., et al. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm950801q · Cited by 259 · see citing works
NMDA receptor regulation of memory and behavior in humans
Newcomer, J. W., & Krystal, J. (2001) · Hippocampus · doi:10.1002/hipo.1069 · Cited by 258 · see citing works
Self-citation
GABAergic local circuit neurons and prefrontal cortical dysfunction in schizophrenia
Lewis, D. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00042-9 · Cited by 257 · see citing works
Altered GABA neurotransmission and prefrontal cortical dysfunction in schizophrenia
Lewis, D. A., Pierri, J. N., Volk, D. W., Melchitzky, D. S., & Woo, T.-U. W. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00061-x · Cited by 256 · see citing works
Double-Blind, Placebo-Controlled, Crossover Trial of Glycine Adjuvant Therapy for Treatment-Resistant Schizophrenia
Heresco‐Levy, U., Javitt, D. C., Ermilov, M., Mordel, C., Horowitz, A., & Kelly, D. (1996) · The British Journal of Psychiatry · doi:10.1192/bjp.169.5.610 · Cited by 255 · see citing works
Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia
GOFF, D. C., Tsai, G. E., Manoach, D. S., & Coyle, J. T. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.8.1213 · Cited by 243 · see citing works
Interactive effects of subanesthetic ketamine and haloperidol in healthy humans
Krystal, J. H., D’Souza, D. C., Karper, L. P., Bennett, A., Abi‐Dargham, A., Abi‐Saab, D., Cassello, K., Bowers, M. B., Vegso, S., Heninger, G. R., et al. (1999) · Psychopharmacology · doi:10.1007/s002130051049 · Cited by 243 · see citing works
Self-citation
Effect of Divalproex Combined with Olanzapine or Risperidone in Patients with an Acute Exacerbation of Schizophrenia
Casey, D. E., Daniel, D. G., Wassef, A. A., Tracy, K. A., Wozniak, P., & Sommerville, K. W. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300023 · Cited by 232 · see citing works
NMDA Agonists and Antagonists as Probes of Glutamatergic Dysfunction and Pharmacotherapies in Neuropsychiatric Disorders
Krystal, J. H., D’Souza, C., Petrakis, I. L., Belger, A., Berman, R., Charney, D. S., Abi‐Saab, W., & Madonick, S. H. (1999) · Harvard Review of Psychiatry · doi:10.3109/hrp.7.3.125 · Cited by 232 · see citing works
Self-citation
Measurement of Glutamate and Glutamine in the Medial Prefrontal Cortex of Never-Treated Schizophrenic Patients and Healthy Controls by Proton Magnetic Resonance Spectroscopy
Bartha, R. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830220085012 · Cited by 230 · see citing works
d- Serine Added to Clozapine for the Treatment of Schizophrenia
Tsai, G. E., Yang, P., Chung, L.-C., Tsai, I.-C., Tsai, C.-W., & Coyle, J. T. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1822 · Cited by 227 · see citing works
Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia
Eastwood, S. L., Burnet, P. W. J., & Harrison, P. J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00586-t · Cited by 223 · see citing works
SR 142801, The first potent non-peptide antagonist of the tachykinin NK3 receptor
Emonds‐Alt, X., Bichon, D., Ducoux, J.-P., Héaulme, M., Miloux, B., Poncelet, M., Proietto, V., Broeck, D. V., Vilain, P., Neliat, G., et al. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00413-m · Cited by 217 · see citing works
The density and spatial distribution of gabaergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia
Cotter, D., Landau, S., Beasley, C. L., Stevenson, R. N., Chana, G., MacMillan, L., & Everall, I. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01243-4 · Cited by 211 · see citing works
A Placebo-Controlled Pilot Study of the Ampakine CX516 Added to Clozapine in Schizophrenia
GOFF, D. C., Leahy, L., Berman, I., Posever, T. A., Herz, L. R., Leon, A. C., Johnson, S. A., & LYNCH, G. S. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200110000-00005 · Cited by 209 · see citing works
The NMDA Antagonist Model for Schizophrenia: Promise and Pitfalls
Abi-Saab, W., D'Souza, D., Moghaddam, B., & Krystal, J. (1998) · Pharmacopsychiatry · doi:10.1055/s-2007-979354 · Cited by 208 · see citing works
Self-citation
Ketamine: a review of its pharmacologic properties and use in ambulatory anesthesia.
(1992) · PubMed Central · Cited by 207 · see citing works
Regional Brain Function in Schizophrenia
Gur, R. E. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800140021003 · Cited by 206 · see citing works
Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients
Siegel, B. V., Buchsbaum, M. S., Bunney, W. E., Gottschalk, L. A., Haier, R. J., Lohr, J. B., Lottenberg, S., Najafi, A., Nuechterlein, K. H., & Potkin, S. G. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.9.1325 · Cited by 201 · see citing works
Lamotrigine inhibits Ca2+ currents in cortical neurons: functional implications
Stefani, A., Spadoni, F., Siniscalchi, A., & Bernardi, G. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00265-8 · Cited by 200 · see citing works
The Effects of a Selective D4 Dopamine Receptor Antagonist (L-745,870) in Acutely Psychotic Inpatients With Schizophrenia
Kramer, M. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830180085011 · Cited by 199 · see citing works
Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia
Cleghorn, J. M., Garnett, E. S., Nahmias, C., Firnau, G., Brown, G. M., Kaplan, R. D., Szechtman, H., & Szechtman, B. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90040-1 · Cited by 197 · see citing works
Reduced GABA uptake sites in the temporal lobe in schizophrenia
Simpson, M. D. C., Slater, P., Deakin, J. F. W., Royston, M. C., & Skan, W. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90819-7 · Cited by 192 · see citing works
Schizophrenia and the parvalbumin-containing class of cortical local circuit neurons
Woo, T., Miller, J. L., & Lewis, D. A. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.7.1013 · Cited by 191 · see citing works
Lamotrigine in treatment-resistant schizophrenia: a randomized placebo-controlled crossover trial
Tiihonen, J., Hallikainen, T., Ryynänen, O., Repo‐Tiihonen, E., Kotilainen, I., Eronen, M., Toivonen, P., Wahlbeck, K., & Putkonen, A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00524-9 · Cited by 191 · see citing works
Expression of Excitatory Amino Acid Transporter Transcripts in the Thalamus of Subjects With Schizophrenia
Smith, R. E., Haroutunian, V. H., Davis, K. L., & Meador‐Woodruff, J. H. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.9.1393 · Cited by 190 · see citing works
Local circuit neurons of the prefrontal cortex in schizophrenia: selective increase in the density of calbindin-immunoreactive neurons
DAVISS, S. R., & Lewis, D. A. (1995) · Psychiatry Research · doi:10.1016/0165-1781(95)02720-3 · Cited by 187 · see citing works
Control of NMDA Receptor Activation by a Glycine Transporter Co-Expressed in Xenopus Oocytes
Supplisson, S., & Bergman, C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04580.1997 · Cited by 184 · see citing works
Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans
Krystal, J. H., Karper, L. P., Bennett, A., D’Souza, D. C., Abi‐Dargham, A., Morrissey, K., Abi‐Saab, D., Bremner, J. D., Bowers, M. B., Suckow, R. F., et al. (1998) · Psychopharmacology · doi:10.1007/s002130050503 · Cited by 184 · see citing works
Self-citation
"Psychedelic" Experiences in Acute Psychoses
Bowers, M. B. (1966) · Archives of General Psychiatry · doi:10.1001/archpsyc.1966.01730150016003 · Cited by 183 · see citing works
D-cycloserine added to clozapine for patients with schizophrenia
GOFF, D. C., Tsai, G. E., Manoach, D. S., Flood, J. G., Darby, D., & Coyle, J. T. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.12.1628 · Cited by 182 · see citing works
Measurement of GABAergic parameters in the prefrontal cortex in schizophrenia: focus on GABA content, GABAA receptor α-1 subunit messenger RNA and human GABA transporter-1 (hGAT-1) messenger RNA expression
Ohnuma, T., Augood, S. J., Arai, H., McKenna, P. J., & Emson, P. C. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00189-x · Cited by 182 · see citing works
Association Between Smaller Left Posterior Superior Temporal Gyrus Volume on Magnetic Resonance Imaging and Smaller Left Temporal P300 Amplitude in First-Episode Schizophrenia
McCarley, R. W., Salisbury, D. F., Hirayasu, Y., Yurgelun-Todd, D. A., Tohen, M. F., Zarate, C. A., Kikinis, R., Jolesz, F. A., & Shenton, M. E. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.4.321 · Cited by 181 · see citing works
Pharmacokinetics of ketamine in man.
Wieber, J., Gugler, R., Hengstmann, J. H., & Dengler, H. J. (1975) · PubMed · Cited by 176 · see citing works
Gamma activity in schizophrenia: evidence of impaired network binding?
Haig, A. R., Gordon, E., Pascalis, V. D., Meares, R. A., Bahramali, H., & Harris, A. W. F. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(00)00347-3 · Cited by 173 · see citing works
The Nagging Question of the Function ofN-Acetylaspartylglutamate
Coyle, J. T. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0153 · Cited by 173 · see citing works
Prefrontal and temporal blood flow in schizophrenia: resting and activation technetium-99m-HMPAO SPECT patterns in young neuroleptic-naive patients with acute disease.
Catafau, A., Parellada, E., Lomeña, F. J., Bernardo, M., Pavı́a, J., Ros, D., SETOAIN, J., & González-Monclús, E. (1994) · PubMed · Cited by 173 · see citing works
Preliminary evidence of improved verbal working memory performance and normalization of task-related frontal lobe activation in schizophrenia following cognitive exercises
Wexler, B. E., Anderson, M., Fulbright, R. K., & Gore, J. C. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1694 · Cited by 172 · see citing works
Brain Activations in Schizophrenia During a Graded Memory Task Studied With Functional Neuroimaging
Fletcher, P. C., McKenna, P. J., Frith, C., Grasby, P. M., Friston, K. J., & Dolan, R. J. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.11.1001 · Cited by 172 · see citing works
Placebo-Controlled Trial of Glycine Added to Clozapine in Schizophrenia
Evins, A. E., Fitzgerald, S. M., Wine, L., Rosselli, R., & GOFF, D. C. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.826 · Cited by 172 · see citing works
Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors.
Stockmeier, C. A., DiCarlo, J., Zhang, Y., et al. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39339-0 · Cited by 171 · see citing works
Clozapine's effectiveness for patients in state hospitals: results from a randomized trial.
Essock, S. M., Hargreaves, W. A., Covell, N. H., & Goethe, J. (1996) · PubMed · Cited by 169 · see citing works
Decreased functional connectivity of EEG theta-frequency activity in first-episode, neuroleptic-naıve patients with schizophrenia: preliminary results
Koenig, T. W., Lehmann, D., Saito, N. H., Kuginuki, T., Kinoshita, T., & Koukkou, M. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00154-7 · Cited by 169 · see citing works
Prefrontal Cortex and Schizophrenia
Wible, C. G. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160029007 · Cited by 167 · see citing works
Work Rehabilitation in Schizophrenia: Does Cognitive Impairment Limit Improvement?
Bell, M. D., & BRYSON, G. J. (2001) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a006873 · Cited by 164 · see citing works
Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics
Krystal, J. H., Petrakis, I. L., Webb, E., Cooney, N. L., Karper, L. P., Namanworth, S. N., Stetson, P. L., Trevisan, L. A., & Charney, D. S. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.4.354 · Cited by 164 · see citing works
Self-citation
Resting Cerebral Glucose Metabolism in First-Episode and Previously Treated Patients With Schizophrenia Relates to Clinical Features
Gur, R. E. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950200047013 · Cited by 156 · see citing works
Subtype Progression and Pathophysiologic Deterioration in Early Schizophrenia
McGlashan, T. H., & Fenton, W. S. (1993) · Schizophrenia Bulletin · doi:10.1093/schbul/19.1.71 · Cited by 152 · see citing works
Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids
Diana, M., Melis, M., & Gessa, G. L. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00292.x · Cited by 152 · see citing works
Natural History of Schizophrenia Subtypes
Fenton, W. S. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810350009002 · Cited by 151 · see citing works
Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia?
Sharp, F. R., Tomitaka, M., Bernaudin, M., & Tomitaka, S. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01817-8 · Cited by 151 · see citing works
Carbamazepine and Haloperidol v Placebo and Haloperidol in Excited Psychoses
Klein, E. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790130061009 · Cited by 150 · see citing works
Changes in Serotonin2A and GABAA Receptors in Schizophrenia
Dean, B., Hussain, T., Hayes, W., Scarr, E., Kitsoulis, S., Hill, C., Opeskin, K., & Copolov, D. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.721593.x · Cited by 148 · see citing works
Chapter 28 The glutamate synapse in neuropsychiatric disorders: Focus on schizophrenia and Alzheimer's disease
Farber, N. B., Newcomer, J. W., & Olney, J. W. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)60453-7 · Cited by 148 · see citing works
Δ9-Tetrahydrocannabinol Acts as a Partial Agonist to Modulate Glutamatergic Synaptic Transmission between Rat Hippocampal Neurons in Culture
Shen, M., & Thayer, S. A. (1999) · Molecular Pharmacology · doi:10.1124/mol.55.1.8 · Cited by 148 · see citing works
Glutamatergic Regulation of Basal and Stimulus‐Activated Dopamine Release in the Prefrontal Cortex
Takahata, R., & Moghaddam, B. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71041443.x · Cited by 144 · see citing works
[3H]Muscimol binding sites increased in autopsied brains of chronic schizophrenics
Hanada, S., Mita, T., Nishino, N., & Tanaka, C. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90341-9 · Cited by 140 · see citing works
Increased Vertical Axon Numbers in Cingulate Cortex of Schizophrenics
Benes, F. M. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800230097015 · Cited by 140 · see citing works
Effect of Clozapine and Adjunctive High-Dose Glycine in Treatment-Resistant Schizophrenia
Potkin, S. G., Jin, Y., Bunney, B. G., COSTA, J. F., & Gulasekaram, B. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.145 · Cited by 139 · see citing works
Voltage‐Activated Calcium Channels: Targets of Antiepileptic Drug Therapy?
Stefani, A., Spadoni, F., & Bernardi, G. (1997) · Epilepsia · doi:10.1111/j.1528-1157.1997.tb01477.x · Cited by 138 · see citing works
Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (1H MRS) in schizophrenic subjects and normal controls
Steel, R. M., Bastin, M. E., McConnell, S., Marshall, I., Owens, D. G. C., Lawrie, S. M., Johnstone, E. C., & Best, J. J. K. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00080-4 · Cited by 138 · see citing works
Temporally-specific retrograde amnesia in two cases of discrete bilateral hippocampal pathology
Kapur, N., & Brooks, D. J. (1999) · Hippocampus · doi:10.1002/(sici)1098-1063(1999)9:3 · Cited by 135 · see citing works
Biexponential kinetics of [3H]MK-801 binding: evidence for access to closed and open N-methyl-D-aspartate receptor channels.
Javitt, D. C., & Zukin, S. R. (1989) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)11243-1 · Cited by 133 · see citing works
Involvement of γ-aminobutyric acid neurotransmission in phencyclidine-induced dopamine release in the medial prefrontal cortex
Yonezawa, Y., Kuroki, T., Kawahara, T., Tashiro, N., & Uchimura, H. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01435-0 · Cited by 133 · see citing works
Increase in meso‐prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids
Diana, M., Melis, M., & Gessa, G. L. (1998) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1998.00292.x · Cited by 129 · see citing works
Augmenting antipsychotic treatment with lamotrigine or topiramate in patients with treatment-resistant schizophrenia: a naturalistic caseseries outcome study
Dursun, S. M., & Deakin, J. F. W. (2001) · Journal of Psychopharmacology · doi:10.1177/026988110101500409 · Cited by 125 · see citing works
The role of N-Methyl-D-Aspartate (NMDA) receptor-mediated neurotransmission in the pathophysiology and therapeutics of psychiatric syndromes
Heresco‐Levy, U., & Javitt, D. C. (1998) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(97)00050-3 · Cited by 122 · see citing works
Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity
Farber, N. B., Kim, S. H., Dikranian, K. T., Jiang, X. P., & Heinkel, C. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000912 · Cited by 122 · see citing works

Flagged first, then by citations

Sorted by citations

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020 · see citing works
NMDA Receptor Hypofunction Produces Opposite Effects on Prefrontal Cortex Interneurons and Pyramidal Neurons
Homayoun, H., & Moghaddam, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2213-07.2007 · Cited by 1,231 · see citing works
The role of default network deactivation in cognition and disease
Anticevic, A., Cole, M. W., Murray, J. D., Corlett, P. R., Wang, X.-J., & Krystal, J. H. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.10.008 · Cited by 978 · see citing works
Self-citation
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686 · see citing works
Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses
Arnsten, A. F. T., Wang, M. J., & Paspalas, C. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.038 · Cited by 538 · see citing works
NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex
Wang, M., Yang, Y., Wang, C.-J., Gamo, N. J., Jin, L. E., Mazer, J. A., Morrison, J. H., Wang, X.-J., & Arnsten, A. F. T. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.032 · Cited by 489 · see citing works
The Frontoparietal Control System: A Central Role in Mental Health
Cole, M. W., Repovš, G., & Anticevic, A. (2014) · The Neuroscientist · doi:10.1177/1073858414525995 · Cited by 461 · see citing works
Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond
Krystal, J. H., Sanacora, G., & Duman, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.026 · Cited by 406 · see citing works
Self-citation
Comparative and Interactive Human Psychopharmacologic Effects of Ketamine and Amphetamine: Implications for Glutamatergic and Dopaminergic Model Psychoses and Cognitive Function
Krystal, J. H., Perry, E. B., Gueorguieva, R., Belger, A., Madonick, S. H., Abi-Dargham, A., Cooper, T. B., MacDougall, L., Abi-Saab, W., & D’Souza, D. C. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.9.985 · Cited by 317 · see citing works
Self-citation
Glutamate and the Neural Basis of the Subjective Effects of Ketamine: A Pharmaco–Magnetic Resonance Imaging Study
Deakin, J. F. W., Lees, J., McKie, S., Hallak, J. E. C., Williams, S. R., & Dursun, S. M. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.37 · Cited by 311 · see citing works
Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects
Krystal, J. H., Abi-Saab, W., Perry, E., D’Souza, D. C., Liu, N., Gueorguieva, R., McDougall, L., Hunsberger, T., Belger, A., Levine, L., et al. (2005) · Psychopharmacology · doi:10.1007/s00213-004-1982-8 · Cited by 272 · see citing works
Self-citation
NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic, A., Gancsos, M., Murray, J. D., Repovs, G., Driesen, N. R., Ennis, D. J., Niciu, M. J., Morgan, P. T., Surti, T. S., Bloch, M. H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208494109 · Cited by 243 · see citing works
Self-citation
Anatomical Abnormalities of the Anterior Cingulate Cortex in Schizophrenia: Bridging the Gap Between Neuroimaging and Neuropathology
Fornito, A., Yucel, M., Dean, B., Wood, S. J., & Pantelis, C. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn025 · Cited by 259 · see citing works
Ketamine and rapid antidepressant action: New treatments and novel synaptic signaling mechanisms
Krystal, J. H., Kavalali, E. T., & Monteggia, L. M. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-023-01629-w · Cited by 262 · see citing works
Self-citation
Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model
Murray, J. D., Anticevic, A., Gancsos, M., Ichinose, M., Corlett, P. R., Krystal, J. H., & Wang, X.-J. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs370 · Cited by 255 · see citing works
Self-citation
Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia
Spencer, K. M., Niznikiewicz, M. A., Nestor, P. G., Shenton, M. E., & McCarley, R. W. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-85 · Cited by 253 · see citing works
Capturing the Angel in "Angel Dust": Twenty Years of Translational Neuroscience Studies of NMDA Receptor Antagonists in Animals and Humans
Moghaddam, B., & Krystal, J. H. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs075 · Cited by 238 · see citing works
Self-citation
Glutamatergic model psychoses: prediction error, learning, and inference
Corlett, P. R., Honey, G. D., Krystal, J. H., & Fletcher, P. C. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.163 · Cited by 229 · see citing works
Self-citation
N-Methyl-D-Aspartate Receptor Antagonist Effects on Prefrontal Cortical Connectivity Better Model Early Than Chronic Schizophrenia
Anticevic, A., Corlett, P. R., Cole, M. W., Savic, A., Gancsos, M., Tang, Y., Repovs, G., Murray, J. D., Driesen, N. R., Morgan, P. T., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.022 · Cited by 181 · see citing works
Self-citation
Clozapine and Haloperidol Differently Suppress the MK-801-Increased Glutamatergic and Serotonergic Transmission in the Medial Prefrontal Cortex of the Rat
López-Gil, X., Babot, Z., Amargós-Bosch, M., Suñol, C., Artigas, F., & Adell, A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301356 · Cited by 183 · see citing works
Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia
Szumlinski, K. K., Lominac, K. D., Kleschen, M. J., Oleson, E. B., Dehoff, M. H., Schwartz, M. K., Seeberg, P. H., Worley, P. F., & Kalivas, P. W. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00120.x · Cited by 181 · see citing works
Potential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists
Krystal, J. H., Mathew, S. J., DʼSouza, D. C., Garakani, A., Gunduz-Bruce, H., & Charney, D. S. (2010) · CNS Drugs · doi:10.2165/11533230-000000000-00000 · Cited by 180 · see citing works
Self-citation
Prefrontal cortex and drug abuse vulnerability: Translation to prevention and treatment interventions
Perry, J. L., Joseph, J. E., Jiang, Y., Zimmerman, R. S., Kelly, T. H., Darna, M., Huettl, P., Dwoskin, L. P., & Bardo, M. T. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.09.001 · Cited by 180 · see citing works
Early-course unmedicated schizophrenia patients exhibit elevated prefrontal connectivity associated with longitudinal change
Anticevic, A., Hu, X., Xiao, Y., Hu, J., Li, F., Bi, F., Cole, M. W., Savic, A., Yang, G. J., Repovs, G., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2310-14.2015 · Cited by 178 · see citing works
Self-citation
Extinction memory is impaired in schizophrenia
Holt, D. J., Lebron-Milad, K., Milad, M. R., Rauch, S. L., Pitman, R. K., Orr, S. P., Cassidy, B. S., Walsh, J. P., & Goff, D. C. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.017 · Cited by 170 · see citing works
Prefrontal cortex-nucleus accumbens interaction: in vivo modulation by dopamine and glutamate in the prefrontal cortex
Del Arco, A., & Mora, F. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.04.011 · Cited by 163 · see citing works
Baseline gamma power during auditory steady-state stimulation in schizophrenia
M. Spencer, K. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00190 · Cited by 155 · see citing works
Local glutamate receptor antagonism in the rat prefrontal cortex disrupts response inhibition in a visuospatial attentional task
Murphy, E. R., Dalley, J. W., & Robbins, T. W. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2068-3 · Cited by 145 · see citing works
Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders
Ayhan, Y., Abazyan, B., Nomura, J., Kim, R., Ladenheim, B., Krasnova, I. N., Sawa, A., Margolis, R. L., Cadet, J. L., Mori, S., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2009.144 · Cited by 148 · see citing works
RETRACTED: Impaired Visual Cortical Plasticity in Schizophrenia
Çavuş, I., Reinhart, R. M. G., Roach, B. J., Gueorguieva, R., Teyler, T. J., Clapp, W. C., Ford, J. M., Krystal, J. H., & Mathalon, D. H. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.013 · Cited by 130 · see citing works
Self-citation
Retracted
Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-d-aspartic acid receptor up-regulation
Gray, L., van den Buuse, M., Scarr, E., Dean, B., & Hannan, A. J. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009085 · Cited by 130 · see citing works
Failure of Neural Responses to Safety Cues in Schizophrenia
Holt, D. J., Coombs, G., Zeidan, M. A., Goff, D. C., & Milad, M. R. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2310 · Cited by 121 · see citing works
Mismatch negativity encoding of prediction errors predicts S-ketamine-induced cognitive impairments
Schmidt, A., Bachmann, R., Kometer, M., Csomor, P. A., Stephan, K. E., Seifritz, E., & Vollenweider, F. X. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.261 · Cited by 121 · see citing works
Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence
Driesen, N. R., Leung, H.-C., Calhoun, V. D., Constable, R. T., Gueorguieva, R., Hoffman, R., Skudlarski, P., Goldman-Rakic, P. S., & Krystal, J. H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.07.029 · Cited by 119 · see citing works
Dopaminergic and <scp>GABA</scp>‐ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex
Jupp, B., Caprioli, D., Saigal, N., Reverte, I., Shrestha, S., Cumming, P., Everitt, B. J., Robbins, T. W., & Dalley, J. W. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12146 · Cited by 109 · see citing works
Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats
Nemeth, C. L., Paine, T. A., Rittiner, J. E., Béguin, C., Carroll, F. I., Roth, B. L., Cohen, B. M., & Carlezon, W. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1834-7 · Cited by 104 · see citing works
Gamma oscillation deficits and the onset and early progression of schizophrenia
Woo, T.-U. W., Spencer, K., & McCarley, R. W. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673221003747609 · Cited by 96 · see citing works
Glutamatergic Modulation of Auditory Information Processing in the Human Brain
Gunduz-Bruce, H., Reinhart, R. M. G., Roach, B. J., Gueorguieva, R., Oliver, S., D'Souza, D. C., Ford, J. M., Krystal, J. H., & Mathalon, D. H. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.031 · Cited by 93 · see citing works
Self-citation
Cannabidiol attenuates sensorimotor gating disruption and molecular changes induced by chronic antagonism of NMDA receptors in mice
Gomes, F. V., Issy, A. C., Ferreira, F. R., Viveros, M.-P., Del Bel, E. A., & Guimarães, F. S. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu041 · Cited by 89 · see citing works
The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects
Hallak, J. E. C., Dursun, S. M., Bosi, D. C., de Macedo, L. R. H., Machado-de-Sousa, J. P., Abrão, J., Crippa, J. A. S., McGuire, P., Krystal, J. H., Baker, G. B., et al. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.002 · Cited by 83 · see citing works
Self-citation
Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia.
Krystal, J. H., Tolin, D. F., Sanacora, G., Castner, S. A., Williams, G. V., Aikins, D. E., Hoffman, R. E., & D'Souza, D. C. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2009.05.002 · Cited by 76 · see citing works
Self-citation
Functional connectivity change as shared signal dynamics
Cole, M. W., Yang, G. J., Murray, J. D., Repovš, G., & Anticevic, A. (2016) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.11.011 · Cited by 60 · see citing works
Second‐by‐second analysis of alpha 7 nicotine receptor regulation of glutamate release in the prefrontal cortex of awake rats
Konradsson‐Geuken, Å., Gash, C. R., Alexander, K., Pomerleau, F., Huettl, P., Gerhardt, G. A., & Bruno, J. P. (2009) · Synapse · doi:10.1002/syn.20693 · Cited by 71 · see citing works
The potential role of lamotrigine in schizophrenia
Large, C. H., Webster, E. L., & Goff, D. C. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0020-9 · Cited by 69 · see citing works
Electrophysiological assessment of auditory stimulus-specific plasticity in schizophrenia
Mears, R. P., & Spencer, K. M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.016 · Cited by 64 · see citing works
Attention deficit induced by blockade of N-methyl d-aspartate receptors in the prefrontal cortex is associated with enhanced glutamate release and cAMP response element binding protein phosphorylation: role of metabotropic glutamate receptors 2/3
Pozzi, L., Baviera, M., Sacchetti, G., Calcagno, E., Balducci, C., Invernizzi, R. W., & Carli, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.060 · Cited by 49 · see citing works
The application of nonlinear dynamic causal modelling for fMRI in subjects at high genetic risk of schizophrenia
Dauvermann, M. R., Whalley, H. C., Romaniuk, L., Valton, V., Owens, D. G. C., Johnstone, E. C., Lawrie, S. M., & Moorhead, T. W. J. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.01.063 · Cited by 49 · see citing works
Role of N-Methyl D-aspartate receptors in action-based predictive coding deficits in schizophrenia
Kort, N. S., Ford, J. M., Roach, B. J., Gunduz-Bruce, H., Krystal, J. H., Jaeger, J., Reinhart, R. M. G., & Mathalon, D. H. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.019 · Cited by 48 · see citing works
Self-citation
Impairment of cognitive performance after reelin knockdown in the medial prefrontal cortex of pubertal or adult rats
Brosda, J., Dietz, F., & Koch, M. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.07.008 · Cited by 37 · see citing works
Prefrontal cortical GABAergic and NMDA glutamatergic regulation of delayed responding
Auger, M. L., & Floresco, S. B. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.09.022 · Cited by 28 · see citing works

Relationship of plasma phencyclidine levels to phencyclidine discrimination in the pigeon
McMillan, D. E., Hardwick, W. C., Cannon, D. J., et al. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90240-6 · Cited by 7 · see citing works
Multiple sites for the regulation of the N-methyl-D-aspartate receptor.
Reynolds, I. J., & Miller, R. J. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13379-8 · Cited by 210 · see citing works
Pharmacological regulation of the phencyclidine‐binding site associated with the N‐methyl‐D‐Aspartate receptor‐operated ion channel
Johnson, K. M., Snell, L. D., Sacaan, A. I., et al. (1989) · Drug Development Research · doi:10.1002/ddr.430170405 · Cited by 18 · see citing works
The Antiseizure Efficacies of MK-801, Phencyclidine, Ketamine, and Memantine Are Altered Selectively by Stress
Deutsch, S. I., Mastropaolo, J. P., Riggs, R. L., & Rosse, R. B. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)90014-9 · Cited by 24 · see citing works
The selective sigma ligand MS-377 attenuates the blockade by phencyclidine of NMDA-induced intracellular calcium
Wang, H., & Takigawa, M. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702002985 · Cited by 5 · see citing works

Authors: Krystal, J. H., D'Souza, D. C., Mathalon, D., Perry, E., Belger, A., & Hoffman, R.
Affiliations: VA Connecticut Healthcare System (US)
Yale University (US)
Yale New Haven Hospital (US)
Corresponding author: Krystal, John H.
ORCID: Krystal, John H.
Mathalon, Daniel
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2003-09-01
Volume: 169
Issue: 3-4
Pages: 215-233
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-003-1582-z
OpenAlex: W2020140782
Cited by: 530
References: 308
Citations by year: 2026: 11 · 2025: 10 · 2024: 11 · 2023: 16 · 2022: 11 · 2021: 15 · 2020: 20 · 2019: 19 · 2018: 24 · 2017: 27 · 2016: 28 · 2015: 28 · 2014: 20 · 2013: 33 · 2012: 40
FWCI: 11.05
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: National Institutes of Health (5k02aa000261-04)
National Institute on Alcohol Abuse and Alcoholism (K02 AA 00261-01)
National Institute of Mental Health (5P50 MH44866-12, P50MH044866)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: schizophrenia, NMDA receptor antagonists, ketamine, glutamatergic function, cortical connectivity, disinhibition, schizophrenia pharmacotherapy, cognitive impairment, translational neuroscience, antipsychotic drug development
MeSH terms: Animals, Cerebral Cortex, Cognition, Humans, Ketamine, Models, Neurological, Neural Pathways, Schizophrenia, Antipsychotic Agents, Receptors, N-Methyl-D-Aspartate, Excitatory Amino Acid Antagonists, Glutamic Acid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks