The DOI matches its Crossref record; 215 of the 215 references it cites were found in a registry or an index.
Inflammation and neuropeptides: the connection in diabetic wound healing
Open accessAbstract
Abnormal wound healing is a major complication of both type 1 and type 2 diabetes, with nonhealing foot ulcerations leading in the worst cases to lower-limb amputation. Wound healing requires the integration of complex cellular and molecular events in successive phases of inflammation, cell proliferation, cell migration, angiogenesis and re-epithelialisation. A link between wound healing and the nervous system is clinically apparent as peripheral neuropathy is reported in 30–50% of diabetic patients and is the most common and sensitive predictor of foot ulceration. Indeed, a bidirectional connection between the nervous and the immune systems and its role in wound repair has emerged as one of the focal features of the wound-healing dogma. This review provides a broad overview of the mediators of this connection, which include neuropeptides and cytokines released from nerve fibres, immune cells and cutaneous cells. In-depth understanding of the signalling pathways in the neuroimmune axis in diabetic wound healing is vital to the development of successful wound-healing therapies.
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Cites
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Cited by
Diabetic Painful and Insensate Neuropathy: Pathogenesis and Potential Treatments
Obrosova, I. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.07.004 · Cited by 272
Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation
Versey, Z., da Cruz Nizer, W. S., Russell, E., Zigic, S., DeZeeuw, K. G., Marek, J. E., Overhage, J., & Cassol, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.648554 · Cited by 253
Substance P Promotes Wound Healing in Diabetes by Modulating Inflammation and Macrophage Phenotype
Leal, E. C., Carvalho, E., Tellechea, A., Kafanas, A., Tecilazich, F., Kearney, C., Kuchibhotla, S., Auster, M. E., Kokkotou, E., Mooney, D. J., et al. (2015) · The American Journal of Pathology · doi:10.1016/j.ajpath.2015.02.011 · Cited by 223
Self-citationCai, Y., Chen, K., Liu, C., & Qu, X. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.04.019 · Cited by 112
Topical application of substance P promotes wound healing in streptozotocin-induced diabetic rats
Kant, V., Kumar, D., Kumar, D., Prasad, R., Gopal, A., Pathak, N. N., Kumar, P., & Tandan, S. K. (2015) · Cytokine · doi:10.1016/j.cyto.2014.12.015 · Cited by 79
Metadata
- Authors
- Pradhan, L., Nabzdyk, C., Andersen, N. D., LoGerfo, F. W., & Veves, A.
- Venue
- Expert Reviews in Molecular Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-01
- Volume
- 11
- Pages
- e2-e2
- ISSN
- 1462-3994 (ISSN-L)
- OpenAlex
- W2143303248
- Cited by
- 285
- References
- 215
- FWCI
- 9.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Pradhan, L., Nabzdyk, C., Andersen, N. D., LoGerfo, F. W., & Veves, A. (2009). Inflammation and neuropeptides: the connection in diabetic wound healing. Expert Reviews in Molecular Medicine. https://doi.org/10.1017/s1462399409000945
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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