The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
LC/MS/MS of carbohydrates with postcolumn addition of metal chlorides using triaxial electrospray probe
Abstract
A new technique for on-line postcolumn addition (PCA) formation and tandem electrospray mass spectrometry of carbohydrate-metal complexes is presented. A metal chloride solution is added to a carbohydrate sample directly within the ion source of the mass spectrometer. Using a triaxial electrospray probe, this technique can be applied to form carbohydrate-metal complexes on-line, without the need of previously mixing the carbohydrate and metal chloride. Two basic tasks may be accomplished: structural analysis and sensitivity enhancement. The performance of this approach is demonstrated through PCA of LiCl, NaCl, KCl, RbCl, CsCl, and CoCl2, introduced via the triaxial probe after chromatographic separation of two four-component carbohydrate mixtures. Each metal-carbohydrate complex is subsequently analyzed by on-line MS and MS/MS. This technique is used to enhance sensitivity and also, in the case of cobalt coordination, to assist in carbohydrate structural elucidation. On-line LC/MS with PCA of LiCl was achieved with as little as 1.7 pmol of oligosaccharide (average consumed amount, 1.7 pmol with 1 microL of a 10 pmol/microL carbohydrate test mixture injection).
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Online Post-column complex formation by addition of metal binding partner has been used, to study carbohydrates67 and siderophores68, respectively, which we here expand to protein targets as binding partners.”
From Native metabolomics identifies the rivulariapeptolide family of protease inhibitors (2022) · cites this paper as [67]
Citations
Cites
Improved electrospray ionization interface for capillary zone electrophoresis-mass spectrometry
Smith, R. D., Barinaga, C. J., & Udseth, H. R. (1988) · Analytical Chemistry · doi:10.1021/ac00169a022 · Cited by 534
Hofmeister, G. E., Zhou, Z., & Leary, J. A. (1991) · Journal of the American Chemical Society · doi:10.1021/ja00016a007 · Cited by 373
Self-citationCarr, S. A., Huddleston, M. J., & Bean, M. F. (1993) · Protein Science · doi:10.1002/pro.5560020207 · Cited by 285
Huddleston, M. J., Annan, R. S., Bean, M. F., & Carr, S. A. (1993) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(93)80049-5 · Cited by 242
Zhou, Z., Ogden, S., & Leary, J. A. (1990) · The Journal of Organic Chemistry · doi:10.1021/jo00307a011 · Cited by 189
Self-citationFura, A., & Leary, J. A. (1993) · Analytical Chemistry · doi:10.1021/ac00068a017 · Cited by 116
Self-citationCharacterization of N-linked oligosaccharides by electrospray and tandem mass spectrometry
Duffin, K. L., Welply, J. K., Huang, E. C., & Henion, J. D. (1992) · Analytical Chemistry · doi:10.1021/ac00037a024 · Cited by 104
Simpson, R. C., Fenselau, C. C., Hardy, M. R., Townsend, R. R., Lee, Y. C., & Cotter, R. J. (1990) · Analytical Chemistry · doi:10.1021/ac00202a005 · Cited by 95
Structural analysis of proteins by capillary HPLC electrospray tandem mass spectrometry
Griffin, P. R., Coffman, J. A., Hood, L., & Yates, J. R. (1991) · International Journal of Mass Spectrometry and Ion Processes · doi:10.1016/0168-1176(91)85052-n · Cited by 88
Lewis, D. A., Guzzetta, A. W., Hancock, W. S., & Costello, M. (1994) · Analytical Chemistry · doi:10.1021/ac00077a003 · Cited by 84
Cited by
Sorted by citations
Mass spectrometry of oligosaccharides
Zaia, J. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.10073 · Cited by 802
GAO, S., Zhang, Z., & Karnes, H. T. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.04.021 · Cited by 230
Application of Fourier transform ion cyclotron resonance mass spectrometry to oligosaccharides
Park, Y., & Lebrilla, C. B. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20010 · Cited by 149
Determination of steroids by liquid chromatography/mass spectrometry
Ma, Y., & Kim, H. (1997) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(97)00122-0 · Cited by 147
Adamson, J. T., & Håkansson, K. (2007) · Analytical Chemistry · doi:10.1021/ac0621423 · Cited by 132
Metadata
- Authors
- Kohler, M., & Leary, J. A.
- Affiliations
- University of California, Berkeley (US)
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1995-10-01
- Volume
- 67
- Issue
- 19
- Pages
- 3501-3508
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2091422516
- Cited by
- 96
- References
- 21
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 3 · 2019: 2 · 2018: 5 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM-47356, R01GM047356)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Chromatography
- Keywords
- LC-MS/MS, metal chlorides, cobalt complexation, sensitivity enhancement
- MeSH terms
- Carbohydrates, Chlorides, Chromatography, Liquid, Metals, Mass Spectrometry
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: LC/MS/MS of carbohydrates with postcolumn addition of metal chlorides using triaxial electrospray probe. https://app.cochat.ai/papers/10.1021/ac00115a019
- The paper
- Kohler, M., & Leary, J. A. (1995). LC/MS/MS of carbohydrates with postcolumn addition of metal chlorides using triaxial electrospray probe. Analytical Chemistry. https://doi.org/10.1021/ac00115a019
