The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Stable Isotope Ratios Using Cavity Ring-Down Spectroscopy: Determination of 13C/12C for Carbon Dioxide in Human Breath
Abstract
We have constructed a cavity ring-down spectrometer employing a near-IR external cavity diode laser capable of measuring 13C/12C isotopic ratios in CO2 in human breath. The system, which has a demonstrated minimum detectable absorption loss of 3.2 x 10(-11) cm(-1) Hz(-1/2), determines the isotopic ratio of 13C16O16O/12C16O16O by measuring the intensities of rotationally resolved absorption features of each species. As in isotope ratio mass spectrometry (IRMS), the isotopic ratio of a sample is compared to that of a standard CO2 sample calibrated to the Pee Dee Belemnite scale and reported as the sample's delta13C value. Measurements of eight replicate CO2 samples standardized by IRMS and consisting of 5% CO2 in N2 at atmospheric pressure demonstrated a precision of 0.22/1000 for the technique. Delta13C values were also obtained for breath samples from individuals testing positive and negative for the presence of Helicobacter pylori, the leading cause of peptic ulcers in humans. This study demonstrates the ability of the instrument to obtain delta13C values in breath samples with sufficient precision to serve as a useful medical diagnostic.
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Cites
Craig, H. (1957) · Geochimica et Cosmochimica Acta · doi:10.1016/0016-7037(57)90024-8 · Cited by 4,170
Cited by
High-power sub-two-cycle mid-infrared pulses at 100 MHz repetition rate
Pupeza, I., Sánchez, D., Zhang, J., Lilienfein, N., Seidel, M., Karpowicz, N., Paasch-Colberg, T., Znakovskaya, I., Pescher, M., Schweinberger, W., et al. (2015) · Nature Photonics · doi:10.1038/nphoton.2015.179 · Cited by 304
Breath Analysis as a Potential and Non-Invasive Frontier in Disease Diagnosis: An Overview
Pereira, J., Porto-Figueira, P., Cavaco, C., Taunk, K., Rapole, S., Dhakne, R., Nagarajaram, H., & Câmara, J. (2015) · Metabolites · doi:10.3390/metabo5010003 · Cited by 301
Metadata
- Authors
- Crosson, E. R., Ricci, K. N., Richman, B. A., Chilese, F. C., Owano, T. G., Provencal, R. A., Todd, M. W., Glasser, J., Kachanov, A. A., Paldus, B. A., Spence, T. G., & Zare, R. N.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-03-19
- Volume
- 74
- Issue
- 9
- Pages
- 2003-2007
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2085469307
- Cited by
- 254
- References
- 1
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- closed
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