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Cited by 676

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A Whole Blood Immunoassay Using Gold Nanoshells

Hirsch, L. R., Jackson, J. B., Lee, A., Halas, N. J., West, J. L.·2003·Analytical Chemistry
DOI 10.1021/ac0262210
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Abstract

A rapid immunoassay capable of detecting analyte within complex biological media without any sample preparation is described. This was accomplished using gold nanoshells, layered dielectric-metal nanoparticles whose optical resonance is a function of the relative size of its constituent layers. Aggregation of antibody/nanoshell conjugates with extinction spectra in the near-infrared was monitored spectroscopically in the presence of analyte. Successful detection of immunoglobulins was achieved in saline, serum, and whole blood. This system constitutes a simple immunoassay capable of detecting sub-nanogram-per-milliliter quantities of various analytes in different media within 10-30 min.

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Metadata

Authors
Hirsch, L. R., Jackson, J. B., Lee, A., Halas, N. J., & West, J. L.
Venue
Analytical Chemistry
Publisher
American Chemical Society (ACS)
Published
2003-04-09
Volume
75
Issue
10
Pages
2377-2381
ISSN
  • 0003-2700 (ISSN-L)
  • 1520-6882
DOI
10.1021/ac0262210
OpenAlex
W2006892956
Cited by
676
References
0
FWCI
28.97
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A Whole Blood Immunoassay Using Gold Nanoshells. https://app.cochat.ai/papers/10.1021/ac0262210
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Hirsch, L. R., Jackson, J. B., Lee, A., Halas, N. J., & West, J. L. (2003). A Whole Blood Immunoassay Using Gold Nanoshells. Analytical Chemistry. https://doi.org/10.1021/ac0262210

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.