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A Whole Blood Immunoassay Using Gold Nanoshells
Abstract
A rapid immunoassay capable of detecting analyte within complex biological media without any sample preparation is described. This was accomplished using gold nanoshells, layered dielectric-metal nanoparticles whose optical resonance is a function of the relative size of its constituent layers. Aggregation of antibody/nanoshell conjugates with extinction spectra in the near-infrared was monitored spectroscopically in the presence of analyte. Successful detection of immunoglobulins was achieved in saline, serum, and whole blood. This system constitutes a simple immunoassay capable of detecting sub-nanogram-per-milliliter quantities of various analytes in different media within 10-30 min.
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Metadata
- Authors
- Hirsch, L. R., Jackson, J. B., Lee, A., Halas, N. J., & West, J. L.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-04-09
- Volume
- 75
- Issue
- 10
- Pages
- 2377-2381
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2006892956
- Cited by
- 676
- References
- 12
- FWCI
- 28.97
- Type
- journal article
- Language
- en
- Open access
- closed
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