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Aptamer-Based Sensor Arrays for the Detection and Quantitation of Proteins
Abstract
Aptamer biosensors have been immobilized on beads, introduced into micromachined chips on the electronic tongue sensor array, and used for the detection and quantitation of proteins. Aptamer chips could detect proteins in both capture and sandwich assay formats. Unlike most protein-based arrays, the aptamer chips could be stripped and reused multiple times. The aptamer chips proved to be useful for screening aptamers from in vitro selection experiments and for sensitively quantitating the biothreat agent ricin.
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Citations
Cited by
Analytical applications of aptamers
Tombelli, S., Minunni, M., & Mascini, M. (2005) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2004.11.006 · Cited by 1,017
Electronic Aptamer‐Based Sensors
Willner, I., & Zayats, M. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604524 · Cited by 818
Applications of Aptamers as Sensors
Cho, E. J., Lee, J.-W., & Ellington, A. D. (2009) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.1.031207.112851 · Cited by 788
Self-citationSynthetic genetic polymers capable of heredity and evolution
Pinheiro, V. B., Taylor, A. I., Cozens, C., Abramov, M., Renders, M., Zhang, S., Chaput, J. C., Wengel, J., Peak-Chew, S.-Y., McLaughlin, S. H., et al. (2012) · Science · doi:10.1126/science.1217622 · Cited by 730
Wang, F., Lu, C.-H., & Willner, I. (2014) · Chemical Reviews · doi:10.1021/cr400354z · Cited by 649
Metadata
- Authors
- Kirby, R., Cho, E. J., Gehrke, B., Bayer, T., Park, Y. S., Neikirk, D. P., McDevitt, J. T., & Ellington, A. D.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-05-25
- Volume
- 76
- Issue
- 14
- Pages
- 4066-4075
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2018483173
- Cited by
- 313
- References
- 0
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kirby, R., Cho, E. J., Gehrke, B., Bayer, T., Park, Y. S., Neikirk, D. P., McDevitt, J. T., & Ellington, A. D. (2004). Aptamer-Based Sensor Arrays for the Detection and Quantitation of Proteins. Analytical Chemistry. https://doi.org/10.1021/ac049858n
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