The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Aptamer-Conjugated Nanoparticles for Selective Collection and Detection of Cancer Cells
Abstract
We have developed a method for the rapid collection and detection of leukemia cells using a novel two-nanoparticle assay with aptamers as the molecular recognition element. An aptamer sequence was selected using a cell-based SELEX strategy in our laboratory for CCRF-CEM acute leukemia cells that, when applied in this method, allows for specific recognition of the cells from complex mixtures including whole blood samples. Aptamer-modified magnetic nanoparticles were used for target cell extraction, while aptamer-modified fluorescent nanoparticles were simultaneously added for sensitive cell detection. Combining two types of nanoparticles allows for rapid, selective, and sensitive detection not possible by using either particle alone. Fluorescent nanoparticles amplify the signal intensity corresponding to a single aptamer binding event, resulting in improved sensitivity over methods using individual dye-labeled probes. In addition, aptamer-modified magnetic nanoparticles allow for rapid extraction of target cells not possible with other separation methods. Fluorescent imaging and flow cytometry were used for cellular detection to demonstrate the potential application of this method for medical diagnostics.
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Cites
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Self-citationAptamers as therapeutic and diagnostic agents
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Cited by
Reddy, L. H., Arias, J. L., Nicolas, J., & Couvreur, P. (2012) · Chemical Reviews · doi:10.1021/cr300068p · Cited by 2,010
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Aptamers from Cell-Based Selection for Bioanalytical Applications
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Self-citationVersatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications
Zhao, N., Yan, L., Zhao, X., Chen, X., Li, A., Zheng, D., Zhou, X., Dai, X., & Xu, F.-J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00401 · Cited by 429
Aptamer−Nanoparticle Strip Biosensor for Sensitive Detection of Cancer Cells
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Self-citation
Metadata
- Authors
- Herr, J. K., Smith, J. E., Medley, C. D., Shangguan, D., & Tan, W.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-03-24
- Volume
- 78
- Issue
- 9
- Pages
- 2918-2924
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2065925882
- Cited by
- 431
- References
- 11
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- closed
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