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Cited by 1,214

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Maximizing DNA Loading on a Range of Gold Nanoparticle Sizes

Open access
Hurst, Sarah J., Lytton-Jean, Abigail K. R., Mirkin, Chad A.·2006·Analytical Chemistry

Abstract

We have investigated the variables that influence DNA coverage on gold nanoparticles. The effects of salt concentration, spacer composition, nanoparticle size, and degree of sonication have been evaluated. Maximum loading was obtained by salt aging the nanoparticles to approximately 0.7 M NaCl in the presence of DNA containing a poly(ethylene glycol) spacer. In addition, DNA loading was substantially increased by sonicating the nanoparticles during the surface loading process. Last, nanoparticles up to 250 nm in diameter were found have approximately 2 orders of magnitude higher DNA loading than smaller (13-30 nm) nanoparticles, a consequence of their larger surface area. Stable large particles are attractive for a variety of biodiagnostic assays.

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Crossref · 10.1021/ac0613582

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Metadata

Authors
Hurst, S. J., Lytton-Jean, A. K. R., & Mirkin, C. A.
Venue
Analytical Chemistry
Published
2006-11-10
Volume
78
Issue
24
Pages
8313-8318
ISSN
  • 0003-2700 (ISSN-L)
  • 1520-6882
OpenAlex
W2015440560
Cited by
1,214
References
2
FWCI
17.69
Type
journal article
Language
en
Open access
green

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