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Cited by 163

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Surface-Enhanced Raman Scattering Based Nonfluorescent Probe for Multiplex DNA Detection

Open access
Sun, Lan, Yu, Chenxu, Irudayaraj, Joseph·2007·Analytical Chemistry

Abstract

To provide rapid and accurate detection of DNA markers in a straightforward, inexpensive, and multiplex format, an alternative surface-enhanced Raman scattering based probe was designed and fabricated to covalently attach both DNA probing sequence and nonfluorescent Raman tags to the surface of gold nanoparticles (DNA-AuP-RTag). The intensity of Raman signal of the probes could be controlled through the surface coverage of the nonfluorescent Raman tags (RTags). Detection sensitivity of these probes could be optimized by fine-tuning the amount of DNA molecules and RTags on the probes. Long-term stability of the DNA-AuP-RTag probes was found to be good (over 3 months). Excellent multiplexing capability of the DNA-AuP-RTag scheme was demonstrated by simultaneous identification of up to eight probes in a mixture. Detection of hybridization of single-stranded DNA to its complementary targets was successfully accomplished with a long-term goal to use nonfluorescent RTags in a Raman-based DNA microarray platform.

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Crossref · 10.1021/ac070078z

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Metadata

Authors
Sun, L., Yu, C., & Irudayaraj, J.
Venue
Analytical Chemistry
Published
2007-04-28
Volume
79
Issue
11
Pages
3981-3988
ISSN
  • 0003-2700 (ISSN-L)
  • 1520-6882
OpenAlex
W1967470447
Cited by
163
References
3
FWCI
7.14
Type
journal article
Language
en
Open access
green

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