Cited by 159Gold and Silver Nanoparticles Synthesis and ApplicationsNanoparticle-Based Drug DeliverySpectroscopy Techniques in Biomedical and Chemical Research

The Fate and Toxicity of Raman-Active Silica-Gold Nanoparticles in Mice

Open access
Thakor, Avnesh S., Luong, Richard, Paulmurugan, Ramasamy, Lin, Frank I., Kempen, Paul, Zavaleta, Cristina, Chu, Pauline, Massoud, Tarik F. +2 more·2011·Science Translational Medicine

Abstract

Gold-core nanoparticles designed for imaging by Raman spectroscopy in patients are generally nontoxic in mice, causing only temporary liver inflammation when given intravenously.

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Crossref · 10.1126/scitranslmed.3001963

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Authors
Thakor, A. S., Luong, R., Paulmurugan, R., Lin, F. I., Kempen, P., Zavaleta, C., Chu, P., Massoud, T. F., Sinclair, R., & Gambhir, S. S.
Affiliations
  • University of Cambridge (GB)
  • Stanford University (US)
  • Stanford Medicine (US)
Corresponding author
Gambhir, Sanjiv S.
Venue
Science Translational Medicine
Published
2011-04-20
Volume
3
Issue
79
Pages
79ra33-79ra33
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2099459454
Cited by
159
References
35
Citations by year
2026: 3 · 2025: 7 · 2024: 5 · 2023: 2 · 2022: 11 · 2021: 12 · 2020: 8 · 2019: 11 · 2018: 14 · 2017: 13 · 2016: 10 · 2015: 15 · 2014: 13 · 2013: 15 · 2012: 13
FWCI
6.13
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (U54CA119367, P50CA114747, U54CA151459)
Topics
  • Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
Keywords
surface-enhanced Raman scattering, PEGylated nanoparticles, acute toxicity, tissue distribution, reticuloendothelial system, macrophage clearance, oxidative stress, liver inflammation, rectal administration, colorectal cancer detection, affibody
MeSH terms
Animals, Female, Gold, Male, Polyethylene Glycols, Silicon Dioxide, Spectrum Analysis, Raman, Mice, Metal Nanoparticles

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