The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Microbial Strain Prioritization Using Metabolomics Tools for the Discovery of Natural Products
Open accessAbstract
Natural products profoundly impact many research areas, including medicine, organic chemistry, and cell biology. However, discovery of new natural products suffers from a lack of high throughput analytical techniques capable of identifying structural novelty in the face of a high degree of chemical redundancy. Methods to select bacterial strains for drug discovery have historically been based on phenotypic qualities or genetic differences and have not been based on laboratory production of secondary metabolites. Therefore, untargeted LC/MS-based secondary metabolomics was evaluated to rapidly and efficiently analyze marine-derived bacterial natural products using LC/MS-principal component analysis (PCA). A major goal of this work was to demonstrate that LC/MS-PCA was effective for strain prioritization in a drug discovery program. As proof of concept, we evaluated LC/MS-PCA for strain selection to support drug discovery, for the discovery of unique natural products, and for rapid assessment of regulation of natural product production.
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Cites
Natural products as sources of new drugs over the 30 years from 1981 to 2010
Newman, D. J., & Cragg, G. M. (2012) · Journal of Natural Products · doi:10.1021/np200906s · Cited by 4,687
Bioactive Microbial Metabolites: A Personal View
Bérdy, J. (2005) · The Journal of Antibiotics · doi:10.1038/ja.2005.1 · Cited by 3,170
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Yang, J. Y., Sanchez, L. M., Rath, C. M., Liu, X., Boudreau, P. D., Bruns, N., Glukhov, E., Wodtke, A., de Felicio, R., Fenner, A., et al. (2013) · Journal of Natural Products · doi:10.1021/np400413s · Cited by 607
Kellogg, J. J., Todd, D. A., Egan, J. M., Raja, H. A., Oberlies, N. H., Kvalheim, O. M., & Cech, N. B. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b01014 · Cited by 189
A marine microbiome antifungal targets urgent-threat drug-resistant fungi
Zhang, F., Zhao, M., Braun, D. R., Ericksen, S. S., Piotrowski, J. S., Nelson, J., Peng, J., Ananiev, G. E., Chanana, S., Barns, K., et al. (2020) · Science · doi:10.1126/science.abd6919 · Cited by 177
Self-citationKurita, K. L., Glassey, E., & Linington, R. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507743112 · Cited by 156
Wang, M., Wang, J., Zhang, Y., Xia, Q., Bi, W., Yang, X., & Chen, D. D. Y. (2016) · Journal of Chromatography A · doi:10.1016/j.chroma.2016.03.061 · Cited by 108
Metadata
- Authors
- Hou, Y., Braun, D. R., Michel, C. R., Klassen, J. L., Adnani, N., Wyche, T. P., & Bugni, T. S.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-05-03
- Volume
- 84
- Issue
- 10
- Pages
- 4277-4283
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W1997603901
- Cited by
- 185
- References
- 2
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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