Bioactive Microbial Metabolites: A Personal View
Abstract
The short history, specific features and future prospects of research of microbial metabolites, including antibiotics and other bioactive metabolites, are summarized. The microbial origin, diversity of producing species, functions and various bioactivities of metabolites, unique features of their chemical structures are discussed, mainly on the basis of statistical data. The possible numbers of metabolites may be discovered in the future, the problems of dereplication of newly isolated compounds as well as the new trends and prospects of the research are also discussed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Actinomycete-isolated secondary metabolites account for ca. 45% (~10,000 compounds) of the total known anti-microbial metabolites.
“Actinomycete-isolated secondary metabolites account for ca. 45% (~10,000 compounds) of the total known anti-microbial metabolites.”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [126]
Of actinomycete-derived compounds, 75% were derived from Streptomyce whereas 25% were derived from rare actinomycetes.
“Of these actinomycete-derived compounds, 75% were derived from Streptomyce whereas 25% were derived from rare actinomycetes [125,126].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [126]
Microbial and plant products occupy the major part of the antimicrobial compounds discovered until now.
“Microbial and plant products occupy the major part of the antimicrobial compounds discovered until now [4].”
From Methods for in vitro evaluating antimicrobial activity: A review (2016) · cites this paper as [4]
Cites
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
Bentley, S. D., Chater, K. F., Cerdeño-Tárraga, A. M., Challis, G. L., Thomson, N. R., James, K., Harris, D. E., Quail, M. A., Kieser, H. M., Harper, D., et al. (2002) · Nature · doi:10.1038/417141a · Cited by 3,226 · see citing works
Ikeda, H., Ishikawa, J., Hanamoto, A., SHINOSE, M., Kikuchi, H., Shiba, T., Sakaki, Y., Hattori, M., & Ōmura, S. (2003) · Nature Biotechnology · doi:10.1038/nbt820 · Cited by 1,238 · see citing works
Fehér, M., & Schmidt, J. M. (2002) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci0200467 · Cited by 926 · see citing works
Advances in Biochemical Engineering/Biotechnology
Chaplin, M. (1985) · Biochemical Education · doi:10.1016/0307-4412(85)90043-3 · Cited by 866 · see citing works
Dictionary of Natural Products
(1995) · Springer eBooks · doi:10.1007/978-1-4899-3316-4 · Cited by 723 · see citing works
The Natural Functions of Secondary Metabolites
Demain, A. L., & Fang, A. (2000) · Advances in biochemical engineering, biotechnology · doi:10.1007/3-540-44964-7_1 · Cited by 722 · see citing works
Drugs from the seas - current status and microbiological implications
Proksch, P., Edrada‐Ebel, R., & Ebel, R. (2002) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-002-1006-8 · Cited by 572 · see citing works
Pharmaceutically active secondary metabolites of microorganisms
Demain, A. L. (1999) · Applied Microbiology and Biotechnology · doi:10.1007/s002530051546 · Cited by 483 · see citing works
Diversifying microbial natural products for drug discovery
Knight-Connoni, V., Sanglier, J., DiTullio, D., Braccili, S., Bonner, P., Waters, J. K., Hughes, D., & Zhang, L. (2003) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1381-9 · Cited by 198 · see citing works
Béahdy, J. (1974) · Advances in applied microbiology · doi:10.1016/s0065-2164(08)70573-2 · Cited by 189 · see citing works
Microbial technologies for the discovery of novel bioactive metabolites
Donadio, S., Monciardini, P., Alduina, R., Mazza, P., Chiocchini, C., Cavaletti, L., Sosio, M., & Puglia, A. M. (2002) · Journal of Biotechnology · doi:10.1016/s0168-1656(02)00209-2 · Cited by 165 · see citing works
Mannopeptimycins, Novel Antibacterial Glycopeptides from Streptomyces hygroscopicus, LL-AC98
He, H., Williamson, R. T., Shen, B., et al. (2002) · Journal of the American Chemical Society · doi:10.1021/ja020257s · Cited by 150 · see citing works
Screening microbial metabolites for new drugs. Theoretical and practical issues.
Yarbrough, G. G., Taylor, D. P., Rowlands, R. T., et al. (1993) · The Journal of Antibiotics · doi:10.7164/antibiotics.46.535 · Cited by 89 · see citing works
Versipelostatin, a novel GRP78/Bip molecular chaperone down-regulator of microbial origin
Park, H.-R., Furihata, K., Hayakawa, Y., et al. (2002) · Tetrahedron Letters · doi:10.1016/s0040-4039(02)01624-6 · Cited by 74 · see citing works
Trends in the search for bioactive microbial metabolites
Ōmura, S. (1992) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/bf01569759 · Cited by 71 · see citing works
Bioactive metabolites from microorganisms
Drummond, A. K. (2009) · NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro) · Cited by 63 · see citing works
Advances in chemical studies on low-molecular weight metabolites of marine fungi
Biabani, M. A. F., & Laatsch, H. (1998) · Journal für praktische Chemie · doi:10.1002/prac.19983400702 · Cited by 62 · see citing works
Targets and assays for discovering novel antibacterial agents
Donadio, S., Carrano, L., Brandi, L., et al. (2002) · Journal of Biotechnology · doi:10.1016/s0168-1656(02)00208-0 · Cited by 59 · see citing works
Bérdy, J., Pauncz, J. K., VAJNA, Z. M., et al. (1977) · The Journal of Antibiotics · doi:10.7164/antibiotics.30.945 · Cited by 50 · see citing works
Self-citationRevised structure of tetrapetalone A and its absolute stereochemistry
Komoda, T., Sugiyama, Y., Abe, N., et al. (2003) · Tetrahedron Letters · doi:10.1016/j.tetlet.2003.08.047 · Cited by 49 · see citing works
RECENT ADVANCES IN AND PROSPECTS OF ANTIBIOTIC RESEARCH
Bérdy, J. (1980) · Cited by 46 · see citing works
Self-citationDiversity of microbial products—discovery and application
Porter, N., & Fox, F. M. (1993) · Pesticide Science · doi:10.1002/ps.2780390210 · Cited by 28 · see citing works
General Aspects of Secondary Metabolism
von Döhren, H., & Gräfe, U. (1997) · Biotechnology · doi:10.1002/9783527620890.ch1 · Cited by 24 · see citing works
Sum, P., How, D., Torres, N., et al. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00542-0 · Cited by 24 · see citing works
Hill, D. C., Wrigley, S. K., & Nisbet, L. J. (2007) · Springer eBooks · doi:10.1007/bfb0102297 · Cited by 19 · see citing works
A facile solid phase synthesis of tetramic acid
Liu, Z., Ruan, X., & Huang, X. L. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00502-x · Cited by 18 · see citing works
Antibiotic identification: A computerized data base system.
BOSTIAN, M., McNitt, K. L., Aszalós, A., et al. (1977) · The Journal of Antibiotics · doi:10.7164/antibiotics.30.633 · Cited by 17 · see citing works
General Aspects of Secondary Metabolism
von Döhren, H., & Gräfe, U. (2001) · Biotechnology Set · doi:10.1002/9783527620999.ch1g · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Methods for in vitro evaluating antimicrobial activity: A review
Balouiri, M., Sadiki, M., & Ibnsouda, S. K. (2016) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2015.11.005 · Cited by 7,264 · see citing works
Antibiotic resistance-the need for global solutions
Laxminarayan, R., Duse, A., Wattal, C., Zaidi, A. K. M., Wertheim, H. F. L., Sumpradit, N., Vlieghe, E., Hara, G. L., Gould, I. M., Goossens, H., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70318-9 · Cited by 4,439 · see citing works
Regulation of Intestinal Barrier Function by Microbial Metabolites
Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works
Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works
“Of these actinomycete-derived compounds, 75% were derived from Streptomyce whereas 25% were derived from rare actinomycetes [125,126].”
BackgroundDiscovery of novel metabolites from marine actinomycetes
Lam, K. S. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.03.004 · Cited by 539 · see citing works
Immense essence of excellence: Marine microbial bioactive compounds
Bhatnagar, I., & Kim, S.-K. (2010) · Marine Drugs · doi:10.3390/md8102673 · Cited by 384 · see citing works
Actinomycetes for marine drug discovery isolated from mangrove soils and plants in China
Hong, K., Gao, A.-H., Xie, Q.-Y., Gao, H. G., Zhuang, L., Lin, H.-P., Yu, H.-P., Li, J., Yao, X.-S., Goodfellow, M., et al. (2009) · Marine Drugs · doi:10.3390/md7010024 · Cited by 372 · see citing works
Antitumor compounds from marine actinomycetes
Olano, C., Méndez, C., & Salas, J. A. (2009) · Marine Drugs · doi:10.3390/md7020210 · Cited by 330 · see citing works
Discovery and development of the anticancer agent salinosporamide A (NPI-0052)
Fenical, W., Jensen, P. R., Palladino, M. A., Lam, K. S., Lloyd, G. K., & Potts, B. C. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.10.075 · Cited by 291 · see citing works
Cho, J. Y., Williams, P. G., Kwon, H. C., Jensen, P. R., & Fenical, W. (2007) · Journal of Natural Products · doi:10.1021/np070101b · Cited by 120 · see citing works
Bioactive substances produced by marine isolates of Pseudomonas
Isnansetyo, A., & Kamei, Y. (2009) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-009-0611-2 · Cited by 86 · see citing works
Ser, H.-L., Law, J. W.-F., Chaiyakunapruk, N., Jacob, S. A., Palanisamy, U. D., Chan, K.-G., Goh, B.-H., & Lee, L.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00522 · Cited by 90 · see citing works
“Microorganisms serve as attractive resources, owing to their ability to synthesize structurally-diverse substances with various bioactivities (Demain, 1999; Newman et al., 2000; Bérdy, 2005; Demain and Sanchez, 2009).”
BackgroundAlvarez-Mico, X., Jensen, P. R., Fenical, W., & Hughes, C. C. (2013) · Organic Letters · doi:10.1021/ol303374e · Cited by 69 · see citing works
The confluence of big data and evolutionary genome mining for the discovery of natural products
Chevrette, M. G., Gavrilidou, A., Mantri, S., Selem-Mojica, N., Ziemert, N., & Barona-Gómez, F. (2021) · Natural Product Reports · doi:10.1039/d1np00013f · Cited by 66 · see citing works
Huang, C., Leung, R. K.-K., Guo, M., Tuo, L., Guo, L., Yew, W. W., Lou, I., Lee, S. M. Y., & Sun, C. (2016) · Scientific Reports · doi:10.1038/srep20667 · Cited by 11 · see citing works
- Authors
- Bérdy, J.
- Corresponding author
- Bérdy, János
- Venue
- The Journal of Antibiotics
- Published
- 2005-01
- Volume
- 58
- Issue
- 1
- Pages
- 1-26
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2009156161
- Cited by
- 3,170
- References
- 28
- Citations by year
- 2026: 75 · 2025: 120 · 2024: 158 · 2023: 187 · 2022: 233 · 2021: 234 · 2020: 219 · 2019: 240 · 2018: 198 · 2017: 210 · 2016: 218 · 2015: 203 · 2014: 176 · 2013: 176 · 2012: 164
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- The Journal of Antibiotics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Debreceni Egyetem
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- microbial metabolites, antibiotics, bioactive metabolites, metabolite diversity, dereplication
- MeSH terms
- Animals, Anti-Bacterial Agents, Humans, Terminology as Topic, Research, Biodiversity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review