Cited by 3,170Microbial Natural Products and BiosynthesisMarine Sponges and Natural ProductsMicrobial Metabolism and Applications

Bioactive Microbial Metabolites: A Personal View

Bérdy, János·2005·The Journal of Antibiotics

Abstract

The short history, specific features and future prospects of research of microbial metabolites, including antibiotics and other bioactive metabolites, are summarized. The microbial origin, diversity of producing species, functions and various bioactivities of metabolites, unique features of their chemical structures are discussed, mainly on the basis of statistical data. The possible numbers of metabolites may be discovered in the future, the problems of dereplication of newly isolated compounds as well as the new trends and prospects of the research are also discussed.

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Crossref · 10.1038/ja.2005.1

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28 of 28 references verified0 citation errors · 0 not checkable

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  • Actinomycete-isolated secondary metabolites account for ca. 45% (~10,000 compounds) of the total known anti-microbial metabolites.

    “Actinomycete-isolated secondary metabolites account for ca. 45% (~10,000 compounds) of the total known anti-microbial metabolites.”

    From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [126]

  • Of actinomycete-derived compounds, 75% were derived from Streptomyce whereas 25% were derived from rare actinomycetes.

    “Of these actinomycete-derived compounds, 75% were derived from Streptomyce whereas 25% were derived from rare actinomycetes [125,126].”

    From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [126]

  • Microbial and plant products occupy the major part of the antimicrobial compounds discovered until now.

    “Microbial and plant products occupy the major part of the antimicrobial compounds discovered until now [4].”

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Authors
Bérdy, J.
Corresponding author
Bérdy, János
Venue
The Journal of Antibiotics
Published
2005-01
Volume
58
Issue
1
Pages
1-26
ISSN
  • 0021-8820 (ISSN-L)
  • 1881-1469
OpenAlex
W2009156161
Cited by
3,170
References
28
Citations by year
2026: 75 · 2025: 120 · 2024: 158 · 2023: 187 · 2022: 233 · 2021: 234 · 2020: 219 · 2019: 240 · 2018: 198 · 2017: 210 · 2016: 218 · 2015: 203 · 2014: 176 · 2013: 176 · 2012: 164
FWCI
4.12
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Antibiotics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Debreceni Egyetem
  • National Cancer Institute
Topics
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
Keywords
microbial metabolites, antibiotics, bioactive metabolites, metabolite diversity, dereplication
MeSH terms
Animals, Anti-Bacterial Agents, Humans, Terminology as Topic, Research, Biodiversity

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