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Detection of Adenosine Triphosphate with an Aptamer Biosensor Based on Surface-Enhanced Raman Scattering
Abstract
A simple, ultrasensitive, highly selective, and reagent-free aptamer-based biosensor has been developed for quantitative detection of adenosine triphosphate (ATP) using surface-enhanced Raman scattering (SERS). The sensor contains a SERS probe made of gold nanostar@Raman label@SiO(2) core-shell nanoparticles in which the Raman label (malachite green isothiocyanate, MGITC) molecules are sandwiched between a gold nanostar core and a thin silica shell. Such a SERS probe brings enhanced signal and low background fluorescence, shows good water-solubility and stability, and exhibits no sign of photobleaching. The aptamer labeled with the SERS probe is designed to hybridize with the cDNA on a gold film to form a rigid duplex DNA. In the presence of ATP, the interaction between ATP and the aptamer results in the dissociation of the duplex DNA structure and thereby removal of the SERS probe from the gold film, reducing the Raman signal. The response of the SERS biosensor varies linearly with the logarithmic ATP concentration up to 2.0 nM with a limit of detection of 12.4 pM. Our work has provided an effective method for detection of small molecules with SERS.
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Cited by
Plasmon-enhanced optical sensors: a review
Li, M., Cushing, S. K., & Wu, N. (2015) · The Analyst · doi:10.1039/c4an01079e · Cited by 1,011
Self-citationOptical aptasensors for quantitative detection of small biomolecules: A review
Feng, C., Dai, S., & Wang, L. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.03.014 · Cited by 300
Self‐Assembled Plasmonic Nanoring Cavity Arrays for SERS and LSPR Biosensing
Im, H., Bantz, K. C., Lee, S. H., Johnson, T. W., Haynes, C. L., & Oh, S. (2013) · Advanced Materials · doi:10.1002/adma.201204283 · Cited by 273
A review of aptamer-based SERS biosensors: Design strategies and applications
Muhammad, M., & Huang, Q. (2021) · Talanta · doi:10.1016/j.talanta.2021.122188 · Cited by 179
Metadata
- Authors
- Li, M., Zhang, J., Suri, S., Sooter, L. J., Ma, D., & Wu, N.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-02-29
- Volume
- 84
- Issue
- 6
- Pages
- 2837-2842
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2080739890
- Cited by
- 197
- References
- 0
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Detection of Adenosine Triphosphate with an Aptamer Biosensor Based on Surface-Enhanced Raman Scattering. https://app.cochat.ai/papers/10.1021/ac203325z
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- Li, M., Zhang, J., Suri, S., Sooter, L. J., Ma, D., & Wu, N. (2012). Detection of Adenosine Triphosphate with an Aptamer Biosensor Based on Surface-Enhanced Raman Scattering. Analytical Chemistry. https://doi.org/10.1021/ac203325z
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