The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Aptamer-Controlled Reversible Inhibition of Gold Nanozyme Activity for Pesticide Sensing
Open accessAbstract
This study addresses the need for rapid pesticide (acetamiprid) detection by reporting a new colorimetric biosensing assay. Our approach combines the inherent peroxidase-like nanozyme activity of gold nanoparticles (GNPs) with high affinity and specificity of an acetamiprid-specific S-18 aptamer to detect this neurotoxic pesticide in a highly rapid, specific, and sensitive manner. It is shown that the nanozyme activity of GNPs can be inhibited by its surface passivation with target-specific aptamer molecules. Similar to an enzymatic competitive inhibition process, in the presence of a cognate target, these aptamer molecules leave the GNP surface in a target concentration-dependent manner, reactivating GNP nanozyme activity. This reversible inhibition of the GNP nanozyme activity can either be directly visualized in the form of color change of the peroxidase reaction product or can be quantified using UV-visible absorbance spectroscopy. This approach allowed detection of 0.1 ppm acetamiprid within an assay time of 10 min. This reversible nanozyme activation/inhibition strategy may in principle be universally applicable for the detection of a range of environmental or biomedical molecules of interest.
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Cites
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Cited by
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Wei, H., & Wang, E. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35486e · Cited by 3,779
Surface modification of nanozymes
Liu, B., & Liu, J. (2017) · Nano Research · doi:10.1007/s12274-017-1426-5 · Cited by 543
Immunomodulation‐Enhanced Nanozyme‐Based Tumor Catalytic Therapy
Xu, B., Cui, Y., Wang, W., Li, S., Lyu, C., Wang, S., Bao, W., Wang, H., Qin, M., Liu, Z., et al. (2020) · Advanced Materials · doi:10.1002/adma.202003563 · Cited by 404
Nanosensors and nanobiosensors in food and agriculture
Srivastava, A. K., Dev, A., & Karmakar, S. (2018) · Environmental Chemistry Letters · doi:10.1007/s10311-017-0674-7 · Cited by 316
Metadata
- Authors
- Weerathunge, P., Ramanathan, R., Shukla, R., Sharma, T. K., & Bansal, V.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-10-28
- Volume
- 86
- Issue
- 24
- Pages
- 11937-11941
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2007865434
- Cited by
- 311
- References
- 34
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Weerathunge, P., Ramanathan, R., Shukla, R., Sharma, T. K., & Bansal, V. (2014). Aptamer-Controlled Reversible Inhibition of Gold Nanozyme Activity for Pesticide Sensing. Analytical Chemistry. https://doi.org/10.1021/ac5028726
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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