The DOI matches its Crossref record.
Electrochemical Impedance Immunosensor Based on Three-Dimensionally Ordered Macroporous Gold Film
Abstract
A novel label-free immunosensor for the detection of C-reactive protein (CRP) was developed based on a three-dimensional ordered macroporous (3DOM) gold film modified electrode by using the electrochemical impedance spectroscopy (EIS) technique. The electrode was electrochemically fabricated with an inverted opal template, making the surface area of the 3DOM gold film up to 14.4 times higher than that of a classical bare flat one, characterized by the cyclic voltammetric (CV) technique. The 3DOM gold film which was composed of interconnected gold nanoparticles not only has a good biocompatible microenvironment but also promotes the increase of conductivity and stability. The CRP immunosensor was developed by covalently conjugating CRP antibodies with 3-mercaptopropionic acid (MPA) on the 3DOM gold film electrode. The CRP concentration was measured through the increase of impedance values in the corresponding specific binding of CRP antigen and CRP antibody. The increased electron-transfer resistance (R(et)) values were proportional to the logarithmic value of CRP concentrations in the range of 0.1 to 20 ng mL(-1). The detection of CRP levels in three sera obtained from hospital showed acceptable accuracy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Electrochemical Impedance Spectroscopy
Chang, B.-Y., & Park, S.-M. (2010) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.012809.102211 · Cited by 1,248
Zhu, C., Du, D., Eychmüller, A., & Lin, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00255 · Cited by 672
Nanomaterials for bio-functionalized electrodes: recent trends
Walcarius, A., Minteer, S. D., Wang, J., Lin, Y., & Merkoçi, A. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20881h · Cited by 366
Privett, B. J., Shin, J. H., & Schoenfisch, M. H. (2010) · Analytical Chemistry · doi:10.1021/ac101075n · Cited by 334
Li, L., Liu, K., Yang, G., Wang, C., Zhang, J., & Zhu, J. (2011) · Advanced Functional Materials · doi:10.1002/adfm.201001550 · Cited by 329
Self-citationHu, K., Lan, D., Li, X., & Zhang, S. (2008) · Analytical Chemistry · doi:10.1021/ac8017197 · Cited by 324
Self-citationBiomolecule-nanoparticle hybrids for electrochemical biosensors
GUO, S., & DONG, S. (2009) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2008.10.014 · Cited by 274
Electrochemical Deposition of Nanomaterials for Electrochemical Sensing
Tonelli, D., Scavetta, E., & Gualandi, I. (2019) · Sensors · doi:10.3390/s19051186 · Cited by 264
Lee, H.-B., Meeseepong, M., Trung, T. Q., Kim, B.-Y., & Lee, N.-E. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112133 · Cited by 153
Metadata
- Authors
- Chen, X., Wang, Y., Zhou, J., Yan, W., Li, X., & Zhu, J.-J.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-02-23
- Volume
- 80
- Issue
- 6
- Pages
- 2133-2140
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2018311431
- Cited by
- 250
- References
- 0
- FWCI
- 16.73
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
