Cited by 153Advanced Sensor and Energy Harvesting MaterialsElectrochemical sensors and biosensorsBiosensors and Analytical Detection

A wearable lab-on-a-patch platform with stretchable nanostructured biosensor for non-invasive immunodetection of biomarker in sweat

Lee, Han-Byeol, Meeseepong, Montri, Trung, Tran Quang, Kim, Bo-Yeong, Lee, Nae-Eung·2020·Biosensors and Bioelectronics

Abstract

Conformable, wearable biosensor-integrated systems are a promising approach to non-invasive and quantitative on-body detection of biomarkers in body fluids. However, realizing such a system has been slowed by the difficulty of fabricating a soft affinity-based biosensor patch capable of precise on-body fluid handling with minimal wearer intervention and a simple measurement protocol. Herein, we demonstrate a conformable, wearable lab-on-a-patch (LOP) platform composed of a stretchable, label-free, impedimetric biosensor and a stretchable microfluidic device for on-body detection of the hormone biomarker, cortisol. The all-in-one, stretchable microfluidic device can precisely collect and deliver sweat for cortisol quantitation and offers one-touch operation of reagent delivery for simultaneous electrochemical signal generation and washing. Three-dimensional nanostructuring of the Au working electrode enables the high sensitivity required to detect the pM-levels of cortisol in sweat. Our integrated LOP detected sweat cortisol quantitatively and accurately during exercise. This LOP will open a new horizon for non-invasive, highly sensitive, and quantitative on-body immunodetection for wearable personal diagnostics.

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Crossref · 10.1016/j.bios.2020.112133

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Authors
Lee, H.-B., Meeseepong, M., Trung, T. Q., Kim, B.-Y., & Lee, N.-E.
Affiliations
Sungkyunkwan University (KR)
Corresponding author
Lee, Nae-Eung
Venue
Biosensors and Bioelectronics
Publisher
Elsevier BV
Published
2020-05
Volume
156
Pages
112133
ISSN
0956-5663 (ISSN-L)
OpenAlex
W3010245527
Cited by
153
References
63
Citations by year
2026: 12 · 2025: 17 · 2024: 24 · 2023: 33 · 2022: 29 · 2021: 28 · 2020: 10
FWCI
7.85
Type
journal article
Language
en
Open access
closed
Locations
  • Biosensors and Bioelectronics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Basic Science Research Program (2019R1A6A1A03033215)
  • Nano Material Technology Development Program (NRF-2016M3A7B4910554)
  • National Research Foundation
  • Ministry of Science, ICT, & Future Planning
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
Keywords
wearable biosensors, impedimetric biosensor, cortisol detection, sweat biomarkers, physical activity, non-invasive diagnosis, personal health monitoring
MeSH terms
Wearable Electronic Devices, Elasticity, Electrodes, Equipment Design, Humans, Hydrocortisone, Immunoassay, Sweat, Biosensing Techniques, Biomarkers, Microfluidic Analytical Techniques, Nanostructures, Lab-On-A-Chip Devices

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