The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Analysis of Ecologically Relevant Pharmaceuticals in Wastewater and Surface Water Using Selective Solid-Phase Extraction and UPLC−MS/MS
Abstract
A rapid and sensitive method has been developed for the analysis of 48 human prescription active pharmaceutical ingredients (APIs) and 6 metabolites of interest, utilizing selective solid-phase extraction (SPE) and ultraperformance liquid chromatography in combination with triple quadrupole mass spectrometry (UPLC-MS/MS). The single-cartridge extraction step was developed using a mixed mode reversed-phase/cation-exchange cartridge (Oasis MCX) and validated in both wastewater effluent and surface water. Recoveries for the majority of compounds ranged from 80% to 125%, with relative standard deviations generally below 15%. Analytes were quantified using a multiple injection analysis with four chromatographic runs, with a combined run time of 48 min and SPE-UPLC-MS/MS method detection limits ranging from 1.0 to 51 ng/L. The analysis of seven wastewater effluents and one surface water sample revealed at least one detection for 38 of the 54 compounds, with effluent concentrations ranging from 7 to 2950 ng/L and surface water concentrations ranging from 10 to 140 ng/L. This initial data demonstrates that a significant number of the selected target analytes are present in wastewater treatment plant discharges.
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Cites
Kolpin, D. W., Furlong, E. T., Meyer, M. T., Thurman, E. M., Zaugg, S. D., Barber, L. B., & Buxton, H. T. (2002) · Environmental Science & Technology · doi:10.1021/es011055j · Cited by 7,953
KOLPIN, D., SKOPEC, M., MEYER, M., FURLONG, E., & ZAUGG, S. (2004) · Science of The Total Environment · doi:10.1016/j.scitotenv.2004.01.015 · Cited by 579
Cited by
Occurrence, sources, and fate of pharmaceuticals in aquatic environment and soil
Li, W. C. (2014) · Environmental Pollution · doi:10.1016/j.envpol.2014.01.015 · Cited by 831
Klosterhaus, S. L., Grace, R., Hamilton, M. C., & Yee, D. (2013) · Environment International · doi:10.1016/j.envint.2013.01.009 · Cited by 368
Pharmaceutical metabolites in the environment: Analytical challenges and ecological risks
Celiz, M. D., Tso, J., & Aga, D. S. (2010) · Environmental Toxicology and Chemistry · doi:10.1897/09-173.1 · Cited by 339
Occurrence, Transformation, and Fate of Antibiotics in Municipal Wastewater Treatment Plants
Zhang, T., & Li, B. (2011) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643380903392692 · Cited by 313
Zhou, J. L., Zhang, Z. L., Banks, E., Grover, D., & Jiang, J. Q. (2009) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2008.11.070 · Cited by 312
Metadata
- Authors
- Batt, A. L., Kostich, M. S., & Lazorchak, J. M.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-05-23
- Volume
- 80
- Issue
- 13
- Pages
- 5021-5030
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2089948166
- Cited by
- 254
- References
- 2
- FWCI
- 17.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Batt, A. L., Kostich, M. S., & Lazorchak, J. M. (2008). Analysis of Ecologically Relevant Pharmaceuticals in Wastewater and Surface Water Using Selective Solid-Phase Extraction and UPLC−MS/MS. Analytical Chemistry. https://doi.org/10.1021/ac800066n
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
