The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Aptamer−Nanoparticle Strip Biosensor for Sensitive Detection of Cancer Cells
Open accessAbstract
We report an aptamer-nanoparticle strip biosensor (ANSB) for the rapid, specific, sensitive, and low-cost detection of circulating cancer cells. Known for their high specificity and affinity, aptamers were first selected from live cells by the cell-SELEX (systematic evolution of ligands by exponential enrichment) process. When next combined with the unique optical properties of gold nanoparticles (Au-NPs), ANSBs were prepared on a lateral flow device. Ramos cells were used as a model target cell to demonstrate proof of principle. Under optimal conditions, the ANSB was capable of detecting a minimum of 4000 Ramos cells without instrumentation (visual judgment) and 800 Ramos cells with a portable strip reader within 15 min. Importantly, ANSB has successfully detected Ramos cells in human blood, thus providing a rapid, sensitive, and low-cost quantitative tool for the detection of circulating cancer cells. ANSB therefore shows great promise for in-field and point-of-care cancer diagnosis and therapy.
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Metadata
- Authors
- Liu, G., Mao, X., Phillips, J. A., Xu, H., Tan, W., & Zeng, L.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-11-11
- Volume
- 81
- Issue
- 24
- Pages
- 10013-10018
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W1999781080
- Cited by
- 340
- References
- 28
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- green
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