The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
A tenascin-C aptamer identified by tumor cell SELEX: Systematic evolution of ligands by exponential enrichment
Open accessAbstract
The targeting of molecular repertoires to complex systems rather than biochemically pure entities is an accessible approach that can identify proteins of biological interest. We have probed antigens presented by a monolayer of tumor cells for their ability to interact with a pool of aptamers. A glioblastoma-derived cell line, U251, was used as the target for systematic evolution of ligands by exponential enrichment by using a single-stranded DNA library. We isolated specifically interacting oligonucleotides, and biochemical strategies were used to identify the protein target for one of the aptamers. Here we characterize the interaction of the DNA aptamer, GBI-10, with tenascin-C, an extracellular protein found in the tumor matrix. Tenascin-C is believed to be involved in both embryogenesis and oncogenesis pathways. Systematic evolution of ligands by exponential enrichment appears to be a successful strategy for the a priori identification of targets of biological interest within complex systems.
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Cited by
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Metadata
- Authors
- Daniels, D. A., Chen, H., Hicke, B. J., Swiderek, K. M., & Gold, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-12-15
- Volume
- 100
- Issue
- 26
- Pages
- 15416-15421
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2053662322
- Cited by
- 567
- References
- 40
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Daniels, D. A., Chen, H., Hicke, B. J., Swiderek, K. M., & Gold, L. (2003). A tenascin-C aptamer identified by tumor cell SELEX: Systematic evolution of ligands by exponential enrichment. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2136683100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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