The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cholesterol Sulfate Imaging in Human Prostate Cancer Tissue by Desorption Electrospray Ionization Mass Spectrometry
Open accessAbstract
Development of methods for rapid distinction between cancerous and non-neoplastic tissues is an important goal in disease diagnosis. To this end, desorption electrospray ionization mass spectrometry (DESI-MS) imaging was applied to analyze the lipid profiles of thin tissue sections of 68 samples of human prostate cancer and normal tissue. The disease state of the tissue sections was determined by independent histopathological examination. Cholesterol sulfate was identified as a differentiating compound, found almost exclusively in cancerous tissues including tissue containing precancerous lesions. The presence of cholesterol sulfate in prostate tissues might serve as a tool for prostate cancer diagnosis although confirmation through larger and more diverse cohorts and correlations with clinical outcome data is needed.
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Cites
Testosterone and Dihydrotestosterone Tissue Levels in Recurrent Prostate Cancer
Titus, M. A., Schell, M. J., Lih, F. B., Tomer, K. B., & Mohler, J. L. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0525 · Cited by 488
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Eberlin, L. S., Norton, I., Dill, A. L., Golby, A. J., Ligon, K. L., Santagata, S., Cooks, R. G., & Agar, N. Y. R. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2465 · Cited by 294
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Self-citationPeripheral membrane associations of matrix metalloproteinases.
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Metadata
- Authors
- Eberlin, L. S., Dill, A. L., Costa, A. B., Ifa, D. R., Cheng, L., Masterson, T., Koch, M., Ratliff, T. L., & Cooks, R. G.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-04-07
- Volume
- 82
- Issue
- 9
- Pages
- 3430-3434
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2066377726
- Cited by
- 192
- References
- 1
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- green
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