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Microchip Electrophoretic Immunoassay for Serum Cortisol
Abstract
An immunoassay performed using a microchip electrophoretic system is described. Separation and quantitation of free and bound labeled antigen in a competitive assay are carried out in channels micromachined into fused silica substrates. Such microchips are attractive because of their small size, ruggedness, and amenability to automated handling. The assay achieves the determination of cortisol in blood serum over the range of clinical interest (1-60 micrograms/dL) without the need for extraction or other sample preparation steps. The separation is performed in less than 30 s. Very high throughput is possible by operating the assay in multiple channels in parallel. These characteristics make microchip electrophoretic systems a promising technology for the rapid analysis of clinical samples.
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Citations
Cited by
Microfluidic chips for clinical and forensic analysis
Verpoorte, E. (2002) · ELECTROPHORESIS · doi:10.1002/1522-2683(200203)23:5<677::aid-elps677>3.0.co;2-8 · Cited by 526
Recent advances in cortisol sensing technologies for point-of-care application
Kaushik, A., Vasudev, A., Arya, S. K., Pasha, S. K., & Bhansali, S. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.09.060 · Cited by 316
High-Speed DNA Genotyping Using Microfabricated Capillary Array Electrophoresis Chips
Woolley, A. T., Sensabaugh, G. F., & Mathies, R. A. (1997) · Analytical Chemistry · doi:10.1021/ac961237+ · Cited by 310
Recent advances in capillary electrophoresis/electrospray/mass spectrometry
Banks, J. F. (1997) · ELECTROPHORESIS · doi:10.1002/elps.1150181216 · Cited by 308
Microfluidic systems in proteomics
Lion, N., Rohner, T. C., Dayon, L., Arnaud, I. L., Damoc, E., Youhnovski, N., Wu, Z., Roussel, C., Josserand, J., Jensen, H., et al. (2003) · ELECTROPHORESIS · doi:10.1002/elps.200305629 · Cited by 262
Metadata
- Authors
- Koutny, L. B., Schmalzing, D., Taylor, T. A., & Fuchs, M.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1996-01-01
- Volume
- 68
- Issue
- 1
- Pages
- 18-22
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W1964139393
- Cited by
- 315
- References
- 0
- FWCI
- 31.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Microchip Electrophoretic Immunoassay for Serum Cortisol. https://app.cochat.ai/papers/10.1021/ac9508311
- The paper
- Koutny, L. B., Schmalzing, D., Taylor, T. A., & Fuchs, M. (1996). Microchip Electrophoretic Immunoassay for Serum Cortisol. Analytical Chemistry. https://doi.org/10.1021/ac9508311
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
