The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Microelectrodes for the Measurement of Catecholamines in Biological Systems
Abstract
Many of the molecules involved in biological signaling processes are easily oxidized and have been monitored by electrochemical methods. Temporal response, spatial considerations, and sensitivity of the electrodes must be optimized for the specific biological application. To monitor exocytosis from single cells in culture, constant potential amperometry offers the best temporal resolution, and a low-noise picoammeter improves the detection limits. Smaller electrodes, with 1-micron diameters, provided spatial resolution sufficient to identify the locations of release sites on the surface of single cells. For the study of neurotransmitter release in vivo, larger cylindrical microelectrodes are advantageous because the secreted molecules come from multiple terminals near the electrode, and the greater amounts lead to a larger signal that emerges from the Johnson noise of the current amplifier. With this approach, dopamine release elicited by two electrical stimulus pulses at 10 Hz was detected with fastscan cyclic voltammetry in vivo. Nafion-coated elliptical electrodes have previously been shown to be incapable of detecting such concentration changes without extensive signal averaging. In addition, we demonstrate that high-pass filtering (200 Hz) of cyclic voltammograms recorded at 300 V/s decreases the background current and digitization noise at these microelectrodes, leading to an improved signal. Also, high-pass filtering discriminated against ascorbic acid, DOPAC, and acidic pH changes, three common interferences in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,831
Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin
Yednock, T. A., Cannon, C., Fritz, L. C., Sanchez-Madrid, F., Steinman, L., & Karin, N. (1992) · Nature · doi:10.1038/356063a0 · Cited by 1,737
Wightman, R. M., Jankowski, J. A., Kennedy, R. T., Kawagoe, K. T., Schroeder, T. J., Leszczyszyn, D. J., Near, J. A., Diliberto, E. J., & Viveros, O. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10754 · Cited by 893
Self-citationMutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
Macchi, P., Villa, A., Giliani, S., Sacco, M. G., Frattini, A., Porta, F., Ugazio, A. G., Johnston, J. A., Candotti, F., O'Sheai, J. J., et al. (1995) · Nature · doi:10.1038/377065a0 · Cited by 877
Gonon, F., Buda, M., Cespuglio, R., Jouvet, M., & Pujol, J.-F. (1980) · Nature · doi:10.1038/286902a0 · Cited by 412
Real-time measurement of transmitter release from single synaptic vesicles
Bruns, D., & Jahn, R. (1995) · Nature · doi:10.1038/377062a0 · Cited by 407
Electrochemical treatment of pyrolytic carbon fiber electrodes
Gonon, F. G., Fombarlet, C. M., Buda, M. J., & Pujol, J. F. (1981) · Analytical Chemistry · doi:10.1021/ac00232a020 · Cited by 404
Principles of voltammetry and microelectrode surface states
Kawagoe, K. T., Zimmerman, J. B., & Wightman, R. M. (1993) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(93)90094-8 · Cited by 394
Self-citationUltrastructural immunocytochemical localization of tyrosine hydroxylase in the neostriatum
Pickel, V. M., Beckley, S. C., Joh, T. H., & Reis, D. J. (1981) · Brain Research · doi:10.1016/0006-8993(81)90843-x · Cited by 329
Voltammetry in the striatum of chronic freely moving rats: Detection of catechols and ascorbic acid
Gonon, F., Buda, M., Cespuglio, R., & Jouvet, M. (1981) · Brain Research · doi:10.1016/0006-8993(81)90807-6 · Cited by 277
Cited by
Electrochemical Monitoring of Single Cell Secretion: Vesicular Exocytosis and Oxidative Stress
Amatore, C., Arbault, S., Guille, M., & Lemaître, F. (2008) · Chemical Reviews · doi:10.1021/cr068062g · Cited by 406
Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation
Garris, P. A., Kilpatrick, M., Bunin, M. A., Michael, D., Walker, Q. D., & Wightman, R. M. (1999) · Nature · doi:10.1038/18019 · Cited by 327
Self-citationEnterochromaffin Cells of the Human Gut: Sensors for Spices and Odorants
Braun, T., Voland, P., Kunz, L., Prinz, C., & Gratzl, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.036 · Cited by 264
Owesson‐White, C. A., Ariansen, J., Stuber, G. D., Cleaveland, N. A., Cheer, J. F., Mark Wightman, R., & Carelli, R. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06916.x · Cited by 126
Hybrid CMOS-Graphene Sensor Array for Subsecond Dopamine Detection
Nasri, B., Wu, T., Alharbi, A., You, K.-D., Gupta, M., Sebastian, S. P., Kiani, R., & Shahrjerdi, D. (2017) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2017.2778048 · Cited by 33
Metadata
- Authors
- Cahill, P. S., Walker, Q. D., Finnegan, J. M., Mickelson, G. E., Travis, E. R., & Wightman, R. M.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1996-01-01
- Volume
- 68
- Issue
- 18
- Pages
- 3180-3186
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2013195053
- Cited by
- 295
- References
- 36
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
