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Cited by 126Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

Neural encoding of cocaine‐seeking behavior is coincident with phasic dopamine release in the accumbens core and shell

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Owesson‐White, Catarina A., Ariansen, Jennifer, Stuber, Garret D., Cleaveland, Nathan A., Cheer, Joseph F., Mark Wightman, R., Carelli, Regina M.·2009·European Journal of Neuroscience
DOI 10.1111/j.1460-9568.2009.06916.xPMC PMC3107700
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Abstract

Mesolimbic dopamine neurons projecting from the ventral tegmental area to the nucleus accumbens (NAc) are part of a complex circuit mediating cocaine‐directed behaviors. However, the precise role of rapid (subsecond) dopamine release within the primary subregions of the NAc (the core and shell) and its relationship to NAc cell firing during this behavior remain unknown. Here, using fast‐scan cyclic voltammetry in rats we report rapid dopamine signaling in both the core and shell; however, significant differences were observed in the timing of dopamine release events within seconds of the cocaine‐reinforced response during self‐administration sessions. Importantly, simultaneous voltammetric and electrophysiological recordings from the same electrode reveal that, at certain sites within both subregions, neurons exhibiting patterned activation were observed at locations where rapid dopamine release was present; the greater the strength of the neural signal the larger the dopamine release event. In addition, it was at those locations that electrically‐evoked stimulated release was greatest. No changes in dopamine were observed where nonphasic neurons were recorded. Thus, although differences are evident in dopamine release dynamics relative to cocaine‐reinforced responding within the core and shell, dopamine release is heterogeneous within each structure and varies as a function of precise neuronal targets during cocaine‐seeking behavior.

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  • Neutral stimuli linked to a reinforcer acquire the ability to increase DA in striatum in anticipation of reward, engendering strong motivation to seek the drug or food.

    “neutral stimuli that are linked to the reinforcer (whether a natural or a drug reinforcer) acquire the ability by themselves to increase DA in striatum (including NAc) in anticipation of the reward, thus engendering a strong motivation to perform and sustain the behaviours necessary to seek the drug or to seek the food (48).”

    From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [48]

  • Stimuli that cause fast and large increases in DA induce conditioned responses and elicit incentive motivation to procure them.

    “stimuli that cause fast and large increases in DA induce conditioned responses and elicit incentive motivation to procure them (48).”

    From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [48]

  • Through conditioning, neutral stimuli linked to the reinforcer acquire the ability by themselves to increase DA in striatum, including the nucleus accumbens, in anticipation of the reward, engendering a strong motivation to seek the drug.

    “This is important because, through the process of conditioning, neutral stimuli that are linked to the reinforcer (whether a natural reinforcer or a drug) acquire the ability by themselves to increase DA in striatum (including NAc) in anticipation of the reward, thus engendering a strong motivation to seek the drug (Owesson-White et al 2009).”

    From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Owesson-White et al 2009

  • DA's role in reinforcement is more complex than just coding for reward per se, and stimuli that induce fast and large DA increases also trigger conditioned responses and elicit incentive motivation to procure them.

    “DA's role in reinforcement is more complex than just coding for reward per se (hedonic pleasure) and stimuli that induce fast and large DA increases also trigger conditioned responses and elicit incentive motivation to procure them (Owesson-White et al 2009).”

    From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Owesson-White et al 2009

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Authors
Owesson‐White, C. A., Ariansen, J., Stuber, G. D., Cleaveland, N. A., Cheer, J. F., Mark Wightman, R., & Carelli, R. M.
Affiliations
University of North Carolina at Chapel Hill (US)
ORCID
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2009-09
Volume
30
Issue
6
Pages
1117-1127
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1111/j.1460-9568.2009.06916.x
PMC
PMC3107700
OpenAlex
W2130709479
Cited by
126
References
74
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 12 · 2018: 8 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 13
FWCI
4.57
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3 d)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • National Institutes of Health
  • National Institute on Drug Abuse (DA10900, DA17318, R01DA017318, R01DA010900)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
cocaine self-administration, cocaine-seeking behavior, phasic dopamine release, nucleus accumbens core, nucleus accumbens shell, mesolimbic dopamine system, ventral tegmental area, neuronal firing patterns, fast-scan cyclic voltammetry
MeSH terms
Action Potentials, Animals, Behavior, Animal, Cocaine, Dopamine, Electrochemistry, Electrophysiology, Kinetics, Male, Neurons, Nucleus Accumbens, Self Administration, Signal Processing, Computer-Assisted, Behavior, Addictive, Rats, Sprague-Dawley, Cocaine-Related Disorders, Rats

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