The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Microelectrodes for the Measurement of Catecholamines in Biological Systems
Abstract
Many of the molecules involved in biological signaling processes are easily oxidized and have been monitored by electrochemical methods. Temporal response, spatial considerations, and sensitivity of the electrodes must be optimized for the specific biological application. To monitor exocytosis from single cells in culture, constant potential amperometry offers the best temporal resolution, and a low-noise picoammeter improves the detection limits. Smaller electrodes, with 1-micron diameters, provided spatial resolution sufficient to identify the locations of release sites on the surface of single cells. For the study of neurotransmitter release in vivo, larger cylindrical microelectrodes are advantageous because the secreted molecules come from multiple terminals near the electrode, and the greater amounts lead to a larger signal that emerges from the Johnson noise of the current amplifier. With this approach, dopamine release elicited by two electrical stimulus pulses at 10 Hz was detected with fastscan cyclic voltammetry in vivo. Nafion-coated elliptical electrodes have previously been shown to be incapable of detecting such concentration changes without extensive signal averaging. In addition, we demonstrate that high-pass filtering (200 Hz) of cyclic voltammograms recorded at 300 V/s decreases the background current and digitization noise at these microelectrodes, leading to an improved signal. Also, high-pass filtering discriminated against ascorbic acid, DOPAC, and acidic pH changes, three common interferences in vivo.
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Citations
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,831
Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin
Yednock, T. A., Cannon, C., Fritz, L. C., Sanchez-Madrid, F., Steinman, L., & Karin, N. (1992) · Nature · doi:10.1038/356063a0 · Cited by 1,737
Wightman, R. M., Jankowski, J. A., Kennedy, R. T., Kawagoe, K. T., Schroeder, T. J., Leszczyszyn, D. J., Near, J. A., Diliberto, E. J., & Viveros, O. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10754 · Cited by 893
Self-citationMutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
Macchi, P., Villa, A., Giliani, S., Sacco, M. G., Frattini, A., Porta, F., Ugazio, A. G., Johnston, J. A., Candotti, F., O'Sheai, J. J., et al. (1995) · Nature · doi:10.1038/377065a0 · Cited by 877
Gonon, F., Buda, M., Cespuglio, R., Jouvet, M., & Pujol, J.-F. (1980) · Nature · doi:10.1038/286902a0 · Cited by 412
Real-time measurement of transmitter release from single synaptic vesicles
Bruns, D., & Jahn, R. (1995) · Nature · doi:10.1038/377062a0 · Cited by 407
Electrochemical treatment of pyrolytic carbon fiber electrodes
Gonon, F. G., Fombarlet, C. M., Buda, M. J., & Pujol, J. F. (1981) · Analytical Chemistry · doi:10.1021/ac00232a020 · Cited by 404
Principles of voltammetry and microelectrode surface states
Kawagoe, K. T., Zimmerman, J. B., & Wightman, R. M. (1993) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(93)90094-8 · Cited by 394
Self-citationUltrastructural immunocytochemical localization of tyrosine hydroxylase in the neostriatum
Pickel, V. M., Beckley, S. C., Joh, T. H., & Reis, D. J. (1981) · Brain Research · doi:10.1016/0006-8993(81)90843-x · Cited by 329
Voltammetry in the striatum of chronic freely moving rats: Detection of catechols and ascorbic acid
Gonon, F., Buda, M., Cespuglio, R., & Jouvet, M. (1981) · Brain Research · doi:10.1016/0006-8993(81)90807-6 · Cited by 277
Direct in Vivo Monitoring of Dopamine Released from Two Striatal Compartments in the Rat
Ewing, A. G., Bigelow, J. C., & Wightman, R. M. (1983) · Science · doi:10.1126/science.6857277 · Cited by 267
Self-citationKawagoe, K. T., Garris, P. A., Wiedemann, D. J., & Wightman, R. M. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90470-m · Cited by 258
Self-citationKristensen, E. W., Kuhr, W. G., & Wightman, R. M. (1987) · Analytical Chemistry · doi:10.1021/ac00141a003 · Cited by 258
Self-citationPihel, K., Walker, Q. D., & Wightman, R. M. (1996) · Analytical Chemistry · doi:10.1021/ac960153y · Cited by 251
Self-citationChergui, K., Suaud-Chagny, M. F., & Gonon, F. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90465-0 · Cited by 229
Evoked Extracellular Dopamine In Vivo in the Medial Prefrontal Cortex
Garris, P. A., Collins, L. B., Jones, S. R., & Wightman, R. M. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb02168.x · Cited by 160
Self-citationCOUPLAND, R. E. (1968) · Nature · doi:10.1038/217384a0 · Cited by 148
Wightman, R. M., Schroeder, T. J., Finnegan, J. M., Ciolkowski, E. L., & Pihel, K. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80199-2 · Cited by 148
Self-citationMarchmont, R. J., & Houslay, M. D. (1980) · Nature · doi:10.1038/286904a0 · Cited by 146
Amperometric monitoring of chemical secretions from individual pancreatic .beta.-cells
Kennedy, R. T., Huang, L., Atkinson, M. A., & Dush, P. J. (1993) · Analytical Chemistry · doi:10.1021/ac00062a012 · Cited by 146
Electrochemical detection of histamine and 5-hydroxytryptamine at isolated mast cells
Pihel, K., Hsieh, S., Jorgenson, J. W., & Wightman, R. M. (1995) · Analytical Chemistry · doi:10.1021/ac00120a014 · Cited by 142
Self-citationContinuousin vivo monitoring of evoked dopamine release in the rat nucleus accumbens by amperometry
Dugast, C., Suaud‐Chagny, M., & Gonon, F. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90466-9 · Cited by 138
Pihel, K., Schroeder, T. J., & Wightman, R. M. (1994) · Analytical Chemistry · doi:10.1021/ac00096a021 · Cited by 138
Self-citationBrazell, M. P., Kasser, R. J., Renner, K. J., Feng, J. X., Moghaddam, B., & Adams, R. N. (1987) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(87)90011-2 · Cited by 136
Primary culture of adrenal medullary chromaffin cells in a chemically defined medium
Wilson, S. P., & Viveros, O. H. (1981) · Experimental Cell Research · doi:10.1016/0014-4827(81)90366-9 · Cited by 130
Striatal dopamine uptake in the rat: In vivo analysis by fast cyclic voltammetry
Stamford, J. A., Kruk, Z. L., Millar, J., & Wightman, R. M. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90274-x · Cited by 122
Self-citationCharacterization of amperometry for in vivo measurement of dopamine dynamics in the rat brain
Kawagoe, K. T., & Wightman, R. M. (1994) · Talanta · doi:10.1016/0039-9140(94)e0064-x · Cited by 117
Self-citationSecretion of Catecholamines from Individual Adrenal Medullary Chromaffin Cells
Leszczyszyn, D. J., Jankowski, J. A., Viveros, O. H., Diliberto, E. J., Near, J. A., & Wightman, R. M. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb03441.x · Cited by 113
Self-citationVoltammetric Methods in Brain Systems
Boulton, A. A., Baker, G. B., & Adams, R. N. (1995) · Humana Press eBooks · doi:10.1385/0896033120 · Cited by 108
Lord, C. J. (1991) · Analytical Chemistry · doi:10.1021/ac00015a018 · Cited by 107
Electronics and Instrumentation for Scientists
Malmstadt, H. V., Enke, C. G., & Crouch, S. R. (1981) · CERN Document Server (European Organization for Nuclear Research) · Cited by 77
Heterogeneity of evoked dopamine overflow wihin the striatal and striatoamygdaloid regions
Garris, P. A., Ciolkowski, E. L., & Wightman, R. M. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90606-8 · Cited by 75
Self-citationFast cyclic voltammetry: Measuring transmitter release in ‘real time’
Stamford, J. A. (1990) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(90)90043-f · Cited by 74
Garris, P. A., & Wightman, R. M. (1995) · Synapse · doi:10.1002/syn.890200311 · Cited by 66
Self-citationJones, S. R., Mickelson, G. E., Collins, L. B., et al. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90048-5 · Cited by 62
Self-citationpH-Dependent processes at Nafion®-coated carbon-fiber microelectrodes
Kawagoe, K. T., Garris, P. A., & Wightman, R. M. (1993) · Journal of Electroanalytical Chemistry · doi:10.1016/0022-0728(93)80409-b · Cited by 42
Self-citation
Cited by
Electrochemical Monitoring of Single Cell Secretion: Vesicular Exocytosis and Oxidative Stress
Amatore, C., Arbault, S., Guille, M., & Lemaître, F. (2008) · Chemical Reviews · doi:10.1021/cr068062g · Cited by 406
Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation
Garris, P. A., Kilpatrick, M., Bunin, M. A., Michael, D., Walker, Q. D., & Wightman, R. M. (1999) · Nature · doi:10.1038/18019 · Cited by 327
Self-citationEnterochromaffin Cells of the Human Gut: Sensors for Spices and Odorants
Braun, T., Voland, P., Kunz, L., Prinz, C., & Gratzl, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.036 · Cited by 264
Owesson‐White, C. A., Ariansen, J., Stuber, G. D., Cleaveland, N. A., Cheer, J. F., Mark Wightman, R., & Carelli, R. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06916.x · Cited by 126
Hybrid CMOS-Graphene Sensor Array for Subsecond Dopamine Detection
Nasri, B., Wu, T., Alharbi, A., You, K.-D., Gupta, M., Sebastian, S. P., Kiani, R., & Shahrjerdi, D. (2017) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2017.2778048 · Cited by 33
Metadata
- Authors
- Cahill, P. S., Walker, Q. D., Finnegan, J. M., Mickelson, G. E., Travis, E. R., & Wightman, R. M.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1996-01-01
- Volume
- 68
- Issue
- 18
- Pages
- 3180-3186
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2013195053
- Cited by
- 295
- References
- 36
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- closed
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