The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Rapid Point-of-Care COVID-19 Diagnosis with a Gold-Nanoarchitecture-Assisted Laser-Scribed Graphene Biosensor
Abstract
The global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has revealed the urgent need for accurate, rapid, and affordable diagnostic tests for epidemic understanding and management by monitoring the population worldwide. Though current diagnostic methods including real-time polymerase chain reaction (RT-PCR) provide sensitive detection of SARS-CoV-2, they require relatively long processing time, equipped laboratory facilities, and highly skilled personnel. Laser-scribed graphene (LSG)-based biosensing platforms have gained enormous attention as miniaturized electrochemical systems, holding an enormous potential as point-of-care (POC) diagnostic tools. We describe here a miniaturized LSG-based electrochemical sensing scheme for coronavirus disease 2019 (COVID-19) diagnosis combined with three-dimensional (3D) gold nanostructures. This electrode was modified with the SARS-CoV-2 spike protein antibody following the proper surface modifications proved by X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) characterizations as well as electrochemical techniques. The system was integrated into a handheld POC detection system operated using a custom smartphone application, providing a user-friendly diagnostic platform due to its ease of operation, accessibility, and systematic data management. The analytical features of the electrochemical immunoassay were evaluated using the standard solution of S-protein in the range of 5.0-500 ng/mL with a detection limit of 2.9 ng/mL. A clinical study was carried out on 23 patient blood serum samples with successful COVID-19 diagnosis, compared to the commercial RT-PCR, antibody blood test, and enzyme-linked immunosorbent assay (ELISA) IgG and IgA test results. Our test provides faster results compared to commercial diagnostic tools and offers a promising alternative solution for next-generation POC applications.
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Cites
A new coronavirus associated with human respiratory disease in China
Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Song, Z.-G., Hu, Y., Tao, Z.-W., Tian, J.-H., Pei, Y.-Y., et al. (2020) · Nature · doi:10.1038/s41586-020-2008-3 · Cited by 11,688
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., Graham, B. S., & McLellan, J. S. (2020) · Science · doi:10.1126/science.abb2507 · Cited by 8,897
Multiplexed Nanomaterial-Based Sensor Array for Detection of COVID-19 in Exhaled Breath
Shan, B., Broza, Y. Y., Li, W., Wang, Y., Wu, S., Liu, Z., Wang, J., Gui, S., Wang, L., Zhang, Z., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c05657 · Cited by 384
Cited by
CRISPR-Cas12a-Derived Photoelectrochemical Biosensor for Point-Of-Care Diagnosis of Nucleic Acid
Zeng, R., Gong, H., Li, Y., Li, Y., Lin, W., Tang, D., & Knopp, D. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c01373 · Cited by 404
Metadata
- Authors
- Beduk, T., Beduk, D., de Oliveira Filho, J. I., Zihnioglu, F., Cicek, C., Sertoz, R., Arda, B., Goksel, T., Turhan, K., Salama, K. N., & Timur, S.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-06-03
- Volume
- 93
- Issue
- 24
- Pages
- 8585-8594
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W3164936482
- Cited by
- 171
- References
- 3
- FWCI
- 10.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Beduk, T., Beduk, D., de Oliveira Filho, J. I., Zihnioglu, F., Cicek, C., Sertoz, R., Arda, B., Goksel, T., Turhan, K., Salama, K. N., & Timur, S. (2021). Rapid Point-of-Care COVID-19 Diagnosis with a Gold-Nanoarchitecture-Assisted Laser-Scribed Graphene Biosensor. Analytical Chemistry. https://doi.org/10.1021/acs.analchem.1c01444
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