The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
2D-Metal–Organic-Framework-Nanozyme Sensor Arrays for Probing Phosphates and Their Enzymatic Hydrolysis
Abstract
The detection of phosphates and their enzymatic hydrolysis is of great importance because of their essential roles in various biological processes and numerous diseases. Compared with individual sensors for detecting one given phosphate at a time, sensor arrays are able to discriminate multiple phosphates simultaneously. Although nanomaterial-based sensor arrays have shown great promise for the discrimination of phosphates, very few of them have been explored for probing phosphates involved enzymatic hydrolysis. To fill this gap, herein we fabricated two-dimensional-metal-organic-framework (2D-MOF)-nanozyme-based sensor arrays by modulating their peroxidase-mimicking activity with various phosphates, including AMP, ADP, ATP, pyrophosphate (PPi), and phosphate (Pi). The sensor arrays were used to successfully discriminate the five phosphates not only in aqueous solutions but also in biological samples. The practical application of the sensor arrays was then validated with blind samples, where 30 unknown samples containing phosphates were accurately identified. Moreover, the sensor arrays were successfully applied to probing hydrolytic processes involving ATP and PPi that are catalyzed by apyrase and PPase, respectively. This work demonstrates a nanozyme-based sensor array as a convenient and reliable analytical platform for probing phosphates and their related enzymatic processes, which could be applied to other analytes and enzymatic reactions.
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Cites
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Gao, L., Zhuang, J., Nie, L., Zhang, J., Zhang, Y., Gu, N., Wang, T., Feng, J., Yang, D., Perrett, S., et al. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.260 · Cited by 7,483
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602
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Wang, K.-Y., Zhang, J., Hsu, Y.-C., Lin, H., Han, Z., Pang, J., Yang, Z., Liang, R.-R., Shi, W., & Zhou, H.-C. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00879 · Cited by 490
Zhang, L., Liu, Z., Deng, Q., Sang, Y., Dong, K., Ren, J., & Qu, X. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202012487 · Cited by 357
Metal–organic framework based nanozymes: promising materials for biochemical analysis
Niu, X., Li, X., Lyu, Z., Pan, J., Ding, S., Ruan, X., Zhu, W., Du, D., & Lin, Y. (2020) · Chemical Communications · doi:10.1039/d0cc04890a · Cited by 328
Nanozyme Sensor Arrays Based on Heteroatom-Doped Graphene for Detecting Pesticides
Zhu, Y., Wu, J., Han, L., Wang, X., Li, W., Guo, H., & Wei, H. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05110 · Cited by 308
Self-citationMetal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts
Ma, L., Jiang, F., Fan, X., Wang, L., He, C., Zhou, M., Li, S., Luo, H., Cheng, C., & Qiu, L. (2020) · Advanced Materials · doi:10.1002/adma.202003065 · Cited by 298
Metadata
- Authors
- Qin, L., Wang, X., Liu, Y., & Wei, H.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-07-25
- Volume
- 90
- Issue
- 16
- Pages
- 9983-9989
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2884180241
- Cited by
- 241
- References
- 2
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- closed
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