Lipid Membrane Permeability of Synthetic Redox DMPC Liposomes Investigated by Single Electrochemical Collisions
Open accessAbstract
The electrochemical detection of synthetic redox DMPC (1,2-dimyristoyl- sn -glycero-3-phosphocholine) liposomes by single collisions at 10 μm diameter carbon and Pt ultramicroelectrodes (UMEs) is reported. To study the parameters influencing the lipid membrane opening/permeability, the electrochemical detection of single redox DMPC liposome collisions at polarized UMEs was investigated under different experimental conditions (addition of surfactant, temperature). The electrochemical responses recorded showed that the permeability of the DMPC lipid membrane (tuned by addition of Triton X-100 surfactant or by the increase of the solution temperature) is a key parameter for the liposome membrane electroporation process and hence for the release and oxidation of its redox content during the collision onto UMEs. The presence of ferrocenemethanol as an additional redox probe in the aqueous solution (at room temperature and without addition of surfactant) is also an interesting strategy to detect current spikes corresponding to single redox DMPC liposome collisions with K 3 Fe(CN) 6 /K 4 Fe(CN) 6 as the encapsulated aqueous redox probe.
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Addition of an optimal concentration of surfactant is required to weaken the liposome lipid bilayer and facilitate its breakdown and release/electrolysis of encapsulated redox probe during impact onto the UME.
“The addition of an optimal concentration of surfactant is required for weakening the liposome's lipid bilayer in order to facilitate its breakdown and the release/electrolysis of its encapsulated redox probe during the impact onto the UME [13,15].”
From Trends in single-impact electrochemistry for bacteria analysis (2023) · cites this paper as [15]
In the presence of redox DMPC liposomes with encapsulated potassium ferrocyanide, no current spike is observed in i-t curves because the liposomes do not spontaneously break during impact onto the UME surface.
“According to previous data, no current spike is observed in the i-t curves in the presence of redox 1,2dimyristoyl-sn-glycero-3-phosphocholine (DMPC) liposomes (with encapsulated potassium ferrocyanide) because they do not spontaneously break during impact onto the UME surface (Fig. 4, left) [13,15].”
From Trends in single-impact electrochemistry for bacteria analysis (2023) · cites this paper as [15]
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Detection of Bacterial Rhamnolipid Toxin by Redox Liposome Single Impact Electrochemistry
Luy, J., Ameline, D., Thobie‐Gautier, C., Boujtita, M., & Lebègue, E. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202111416 · Cited by 27 · see citing works
Self-citationTrends in single-impact electrochemistry for bacteria analysis
Smida, H., Langlard, A., Ameline, D., Thobie-Gautier, C., Boujtita, M., & Lebègue, E. (2023) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-023-04568-z · Cited by 22 · see citing works
Self-citationLebègue, E., Costa, N. L., Louro, R. O., & Barrière, F. (2020) · Journal of The Electrochemical Society · doi:10.1149/1945-7111/ab9e39 · Cited by 17 · see citing works
Self-citationChen, X., Peng, M., Peng, Z., & Zhou, Y. (2026) · Chemistry – A European Journal · doi:10.1002/chem.202503631 · Cited by 1 · see citing works
- Authors
- Lebègue, E., Barrière, F., & Bard, A. J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- The University of Texas at Austin (US)
- Corresponding author
- Bard, Allen J.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-01-09
- Volume
- 92
- Issue
- 3
- Pages
- 2401-2408
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2999089247
- Cited by
- 33
- References
- 2
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 4
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Division of Chemistry (CHE-1405248, CHE-1707384)
- Welch Foundation (F-0021)
- Topics
- Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- DMPC liposomes, lipid membrane permeability, electrochemical detection, ultramicroelectrodes, membrane electroporation, ferrocenemethanol, Triton X-100 surfactant, temperature effects
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