Detection of Bacterial Rhamnolipid Toxin by Redox Liposome Single Impact Electrochemistry
Open accessAbstract
The detection of Rhamnolipid virulence factor produced by Pseudomonas aeruginosa involved in nosocomial infections is reported by using the redox liposome single impact electrochemistry. Redox liposomes based on 1,2‐dimyristoyl‐sn‐glycero‐3‐phosphocholine as a pure phospholipid and potassium ferrocyanide as an encapsulated redox content are designed for using the interaction of the target toxin with the lipid membrane as a sensing strategy. The electrochemical sensing principle is based on the weakening of the liposomes lipid membrane upon interaction with Rhamnolipid toxin which leads upon impact at an ultramicroelectrode to the breakdown of the liposomes and the release/electrolysis of its encapsulated redox probe. We present as a proof of concept the sensitive and fast sensing of a submicromolar concentration of Rhamnolipid which is detected after less than 30 minutes of incubation with the liposomes, by the appearing of current spikes in the chronoamperometry measurement.
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RL is a glycolipidic biosurfactant secreted by Pseudomonas aeruginosa, a pathogenic Gram-negative bacterium involved in nosocomial infections.
“RL is a glycolipidic biosurfactant secreted by Pseudomonas aeruginosa (P.aeruginosa), pathogenic Gram-negative bacteria involved in nosocomial infections [17].”
From Trends in single-impact electrochemistry for bacteria analysis (2023) · cites this paper as [17]
The Abstract states that Pseudomonas aeruginosa secretes the glycolipidic biosurfactant rhamnolipid and is involved in nosocomial infections. It also describes the bacterium as pathogenic, but our copy does not identify it as Gram-negative; that part of the attributed claim is unsupported. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThe detection principle of the redox liposome proof of concept is based on RL-induced weakening of the liposome lipid membrane, leading to liposome breakdown upon impact at a UME and release/electrolysis of the encapsulated redox probe.
“The detection principle in this proof of concept is based on the weakening of the liposomes' lipid membrane caused by the interaction with RL, which leads to the breakdown of the liposomes upon impact at a UME , and the release/electrolysis of its encapsulated redox probe (Fig. 4, right) [17].”
From Trends in single-impact electrochemistry for bacteria analysis (2023) · cites this paper as [17]
The discussion around Figure 2 (labelled Abstract in our copy; page not supplied) says RL weakens the liposome membrane and that current spikes suggest breakdown during impact at a Pt UME, with probable release of the encapsulated redox content. The passage labelled Equation 1 describes breakdown and/or release and electrolysis, rather than establishing that both breakdown and release necessarily occur at each impact. (LLM, conf=0.84)
Experimental — accuracy not yet measuredAn original and recent approach is to detect virulence factors released by pathogenic bacteria rather than the cells themselves, based on redox liposomes single-impact electrochemistry.
“Also, an original and recent approach is to detect the virulence factors released by pathogenic bacteria rather than the cells themselves, based on redox liposomes single-impact electrochemistry [17].”
From Trends in single-impact electrochemistry for bacteria analysis (2023) · cites this paper as [17]
A recent proof of concept has demonstrated highly-sensitive detection of a bacterial virulence factor using redox liposomes single-impact electrochemistry.
“Following an original and innovative strategy, a recent proof of concept presented in the next section has demonstrated the highly-sensitive detection of a bacterial virulence factor thanks to the redox liposomes single-impact electrochemistry [17].”
From Trends in single-impact electrochemistry for bacteria analysis (2023) · cites this paper as [17]
Detection of a sub-micromolar concentration of Rhamnolipid (RL) virulence factor by electrochemical single impacts of redox liposomes is reported.
“In this last section, the detection of a sub-micromolar concentration of Rhamnolipid (RL) virulence factor by electrochemical single impacts of redox liposomes is reported (Fig. 4) [17].”
From Trends in single-impact electrochemistry for bacteria analysis (2023) · cites this paper as [17]
With RL species in solution, current spikes corresponding to electrolysis of encapsulated redox probe released from weakened liposomes during collision onto the UME can be detected in chronoamperometry.
“Hence, with RL species in solution, current spikes corresponding to the electrolysis of the encapsulated redox probe released from weakened liposomes during the collision onto the UME can be detected in the chronoamperometry measurement (Fig. 4, middle) [17].”
From Trends in single-impact electrochemistry for bacteria analysis (2023) · cites this paper as [17]
The characteristic of redox DMPC liposomes has been used to detect the lowest concentration of RL reported in the literature for electrochemical sensing, by exploiting RL's ability to act as a biosurfactant on the liposome lipid membrane.
“This characteristic specific to the redox DMPC liposomes have been used for detecting the lowest concentration of RL reported in the literature for electrochemical sensing, by using the ability of this virulence factor to act as a biosurfactant on the liposome lipid membrane [17].”
From Trends in single-impact electrochemistry for bacteria analysis (2023) · cites this paper as [17]
Preliminary results based on redox DMPC liposomes allowed detection of 500 nM RL in aqueous phosphate buffer solution in less than 30 minutes using single-impact electrochemistry at a Pt UME.
“These preliminary results based on redox DMPC liposomes have allowed the detection of a low concentration of RL (500 nM) in an aqueous phosphate buffer solution in less than 30 minutes thanks to the electrochemistry of single impacts at a Pt UME [17].”
From Trends in single-impact electrochemistry for bacteria analysis (2023) · cites this paper as [17]
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Langlard, A., Gu, H., Ewing, A. G., & Lebègue, E. (2025) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2025.109166 · Cited by 2 · see citing works
Self-citationDirect faradaic impacts in single-entity electrochemistry
Langlard, A., Thobie‐Gautier, C., Boujtita, M., & Lebègue, E. (2026) · Current Opinion in Electrochemistry · doi:10.1016/j.coelec.2026.101892 · Cited by 2 · see citing works
Self-citationChen, X., Peng, M., Peng, Z., & Zhou, Y. (2026) · Chemistry – A European Journal · doi:10.1002/chem.202503631 · Cited by 1 · see citing works
Quantifying proton transport kinetics of gramicidin A channel at the single-vesicle level
Yang, S., Tian, S., Zhao, Y., Li, Z., & Ma, W. (2026) · Science China Chemistry · doi:10.1007/s11426-025-3333-4 · Cited by 1 · see citing works
Liu, H.-F., Pang, H. Y., Hu, Z., Pan, Z.-T., Zhang, H., Zhang, X., & Huang, F. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.137911
Hydrogen Evolution Reaction on a Single Platinum Atom
Wong, E. N. (2025) · doi:10.26686/wgtn.28782017
Hu, R., Wang, W., & Wang, H. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c01916
Electrochemiluminescence Bio-Imaging
Knežević, S., Han, D., Huang, X., Liu, B., Jiang, D., & Šojić, N. (2026) · Springer eBooks · doi:10.1007/978-3-032-14602-1_8
Pensieri, A., Delacotte, J., Lemaître, F., Guille‐Collignon, M., Yamada, A., Šojić, N., Thouin, L., Labbé, É., & Buriez, O. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c01886
- Authors
- Luy, J., Ameline, D., Thobie‐Gautier, C., Boujtita, M., & Lebègue, E.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Lebègue, Estelle
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2021-12-02
- Volume
- 61
- Issue
- 6
- Pages
- e202111416-e202111416
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3216047679
- Cited by
- 27
- References
- 50
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 5
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Conseil Régional des Pays de la Loire (PULSAR)
- Université de Nantes
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- Pseudomonas aeruginosa, ultramicroelectrodes, potassium ferrocyanide, lipid membrane disruption, chronoamperometry, electrochemical biosensor, nosocomial infections
- MeSH terms
- Bacterial Toxins, Glycolipids, Liposomes, Oxidation-Reduction, Phosphatidylethanolamines, Pseudomonas aeruginosa, Electrochemical Techniques
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