Detection of Alkynes via Click Chemistry with a Brominated Coumarin Azide by Simultaneous Fluorescence and Isotopic Signatures in Mass Spectrometry

Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition

Wang, Q., Chan, T. R., Hilgraf, R., Fokin, V. V., Sharpless, K. B., & Finn, M. G. (2003) · Journal of the American Chemical Society · doi:10.1021/ja021381e · Cited by 1,638 · see citing works

Proteome-wide covalent ligand discovery in native biological systems

Backus, K. M., Correia, B. E., Lum, K. M., Forli, S., Horning, B. D., González-Páez, G. E., Chatterjee, S., Lanning, B. R., Teijaro, J. R., Olson, A. J., et al. (2016) · Nature · doi:10.1038/nature18002 · Cited by 940 · see citing works

Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation

McKay, C. S., & Finn, M. G. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.09.002 · Cited by 771 · see citing works

A Fluorogenic 1,3-Dipolar Cycloaddition Reaction of 3-Azidocoumarins and Acetylenes

Sivakumar, K., Xie, F., Cash, B. M., Long, S., Barnhill, H. N., & Wang, Q. (2004) · Organic Letters · doi:10.1021/ol047955x · Cited by 700 · see citing works

Site-specific antibody drug conjugates for cancer therapy

Panowski, S. H., Bhakta, S., Raab, H. E., Polakis, P. G., & Junutula, J. R. (2013) · mAbs · doi:10.4161/mabs.27022 · Cited by 677 · see citing works

Byonic: Advanced Peptide and Protein Identification Software

Bern, M., Kil, Y. J., & Becker, C. (2012) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi1320s40 · Cited by 659 · see citing works

Choosing an effective protein bioconjugation strategy

Stephanopoulos, N., & Francis, M. B. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.720 · Cited by 636 · see citing works

Mass spectrometry-based proteomics: existing capabilities and future directions

Angel, T. E., Aryal, U. K., Hengel, S. M., Baker, E. S., Kelly, R., Robinson, E. W., & Smith, R. D. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15331a · Cited by 443 · see citing works

Copper‐Catalyzed Azide–Alkyne Click Chemistry for Bioconjugation

Presolski, S. I., Hong, V., & Finn, M. G. (2011) · Current Protocols in Chemical Biology · doi:10.1002/9780470559277.ch110148 · Cited by 409 · see citing works

Growing Applications of “Click Chemistry” for Bioconjugation in Contemporary Biomedical Research

Nwe, K., & Brechbiel, M. W. (2009) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2008.0626 · Cited by 310 · see citing works

Systematic and quantitative comparison of digest efficiency and specificity reveals the impact of trypsin quality on MS-based proteomics

Burkhart, J. M., Schumbrutzki, C., Wortelkamp, S., Sickmann, A., & Zahedi, R. P. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.11.016 · Cited by 297 · see citing works

Chances and pitfalls of chemical cross-linking with amine-reactive N-hydroxysuccinimide esters

Kalkhof, S., & Sinz, A. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2231-5 · Cited by 282 · see citing works

Genetic Incorporation of a Small, Environmentally Sensitive, Fluorescent Probe into Proteins in Saccharomyces cerevisiae

Lee, H. S., Guo, J., Lemke, E. A., Dimla, R. D., & Schultz, P. G. (2009) · Journal of the American Chemical Society · doi:10.1021/ja904896s · Cited by 226 · see citing works

Rapid Preparation of Released <i>N</i> -Glycans for HILIC Analysis Using a Labeling Reagent that Facilitates Sensitive Fluorescence and ESI-MS Detection

Lauber, M. A., Yu, Y.-Q., Brousmiche, D. W., Hua, Z., Koza, S. M., Magnelli, P., Guthrie, E., Taron, C. H., & Fountain, K. J. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b00758 · Cited by 211 · see citing works

The Implications of Proteolytic Background for Shotgun Proteomics

Picotti, P., Aebersold, R. H., & Domon, B. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700029-mcp200 · Cited by 193 · see citing works

NHS-Esters As Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots

Ward, C. C., Kleinman, J. I., & Nomura, D. K. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00125 · Cited by 158 · see citing works

Iterative In Situ Click Chemistry Creates Antibody‐like Protein‐Capture Agents

Agnew, H. D., Rohde, R. D., Millward, S. W., Nag, A., Yeo, W., Hein, J. E., Pitram, S. M., Tariq, A. A., Burns, V. M., Krom, R. J., et al. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900488 · Cited by 131 · see citing works

Comparative Analysis of Cleavable Azobenzene-Based Affinity Tags for Bioorthogonal Chemical Proteomics

Yang, Y., Grammel, M., Raghavan, A. S., Charron, G., & Hang, H. C. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.09.012 · Cited by 122 · see citing works

Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template

Grimster, N. P., Stump, B., Fotsing, J. R., Weide, T., Talley, T. T., Yamauchi, J. G., Nemecz, Á., Kim, C., Ho, K., Sharpless, K. B., et al. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3001858 · Cited by 91 · see citing works

Chemoproteomic profiling and discovery of protein electrophiles in human cells

Matthews, M. L., He, L., Horning, B. D., Olson, E. J., Correia, B. E., Yates, J. R., Dawson, P. E., & Cravatt, B. F. (2017) · Nature Chemistry · doi:10.1038/nchem.2645 · Cited by 90 · see citing works

Applications of Copper-Catalyzed Click Chemistry in Activity-Based Protein Profiling

Martell, J., & Weerapana, E. (2014) · Molecules · doi:10.3390/molecules19021378 · Cited by 82 · see citing works

Conjugation Site Heterogeneity Causes Variable Electrostatic Properties in Fc Conjugates

Boylan, N. J., Zhou, W., Proos, R. J., et al. (2013) · Bioconjugate Chemistry · doi:10.1021/bc4000564 · Cited by 80 · see citing works

Unexpected products from the reaction of the synthetic cross-linker 3,3′-dithiobis(sulfosuccinimidyl propionate), DTSSP with peptides

Swaim, C. L., Smith, J. B., & Smith, D. L. (2004) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2004.01.011 · Cited by 74 · see citing works

Determination of avermectin and milbemycin residues in bovine muscle by liquid chromatography-tandem mass spectrometry and fluorescence detection using solvent extraction and low temperature cleanup

Rübensam, G., Barreto, F., Hoff, R. B., et al. (2012) · Food Control · doi:10.1016/j.foodcont.2012.05.075 · Cited by 72 · see citing works

Isotopic Signature Transfer and Mass Pattern Prediction (IsoStamp): An Enabling Technique for Chemically-Directed Proteomics

Palaniappan, K. K., Pitcher, A. A., Smart, B. P., Spiciarich, D. R., Iavarone, A. T., & Bertozzi, C. R. (2011) · ACS Chemical Biology · doi:10.1021/cb100338x · Cited by 59 · see citing works

Reengineering Antibiotics to Combat Bacterial Resistance: Click Chemistry [1,2,3]‐Triazole Vancomycin Dimers with Potent Activity against MRSA and VRE

Silverman, S. M., Moses, J. E., & Sharpless, K. B. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201604765 · Cited by 57 · see citing works

Lysine conjugation properties in human IgGs studied by integrating high‐resolution native mass spectrometry and bottom‐up proteomics

Gautier, V., Boumeester, A. J., Lössl, P., & Heck, A. J. R. (2015) · PROTEOMICS · doi:10.1002/pmic.201400462 · Cited by 53 · see citing works

Balancing the False Negative and Positive Rates in Suspect Screening with High-Resolution Orbitrap Mass Spectrometry Using Multivariate Statistics

Vergeynst, L., Langenhove, H. R. V., & Demeestere, K. (2015) · Analytical Chemistry · doi:10.1021/ac503426k · Cited by 49 · see citing works

Crosslinking Studies of Protein-Protein Interactions in Nonribosomal Peptide Biosynthesis

Hur, G. H., Meier, J. L., Baskin, J. M., et al. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.02.009 · Cited by 47 · see citing works

Chemical Methods for the Detection of Protein N-Homocysteinylation via Selective Reactions with Aldehydes

Zang, T., Dai, S., Chen, D., et al. (2009) · Analytical Chemistry · doi:10.1021/ac9017132 · Cited by 45 · see citing works

Chemoproteomic Strategy to Quantitatively Monitor Transnitrosation Uncovers Functionally Relevant S -Nitrosation Sites on Cathepsin D and HADH2

Zhou, Y., Wynia‐Smith, S. L., Couvertier, S. M., Kalous, K., Marletta, M. A., Smith, B. C., & Weerapana, E. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2016.05.008 · Cited by 43 · see citing works

Development and Use of Clickable Activity Based Protein Profiling Agents for Protein Arginine Deiminase 4

Slack, J. L., Causey, C. P., Luo, Y., & Thompson, P. R. (2011) · ACS Chemical Biology · doi:10.1021/cb1003515 · Cited by 42 · see citing works

Click Chemistry Facilitates Formation of Reporter Ions and Simplified Synthesis of Amine-Reactive Multiplexed Isobaric Tags for Protein Quantification

Sohn, C. H., Lee, J. E., Sweredoski, M. J., Graham, R. L. J., Smith, G. T., Hess, S. Y., Czerwieniec, G. A., Loo, J. A., Deshaies, R. J., & Beauchamp, J. L. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2099003 · Cited by 33 · see citing works

Development of clickable active site-directed photoaffinity probes for γ-secretase

Crump, C. J., Ende, C. W. A., Ballard, T. E., et al. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.02.027 · Cited by 27 · see citing works

When Good Intentions Go Awry: Modification of a Recombinant Monoclonal Antibody in Chemically Defined Cell Culture by Xylosone, an Oxidative Product of Ascorbic Acid

Chumsae, C. M., Hossler, P., Raharimampionona, H., Zhou, Y., McDermott, S., Racicot, C., Radziejewski, C. H., & Zhou, Z. S. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b00801 · Cited by 26 · see citing works

Double clicking for site-specific coupling of multiple enzymes

Lim, S. I., Cho, J., & Kwon, I. (2015) · Chemical Communications · doi:10.1039/c5cc04611d · Cited by 25 · see citing works

Chromogenic Chemical Probe for Protein Structural Characterization via Ultraviolet Photodissociation Mass Spectrometry

O’Brien, J. P., Pruet, J. M., & Brodbelt, J. S. (2013) · Analytical Chemistry · doi:10.1021/ac401305f · Cited by 22 · see citing works

A Cautionary Tale on the Inclusion of Variable Posttranslational Modifications in Database-Dependent Searches of Mass Spectrometry Data

Svozil, J., & Baerenfaller, K. (2017) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2016.11.007 · Cited by 22 · see citing works

Sensitive, accurate and rapid detection of trace aliphatic amines in environmental samples with ultrasonic-assisted derivatization microextraction using a new fluorescent reagent for high performance liquid chromatography

Chen, G., Liu, J., Liu, M., et al. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.05.061 · Cited by 18 · see citing works

Rapid Identification of Fluorochrome Modification Sites in Proteins by LC ESI-Q-TOF Mass Spectrometry

Manikwar, P., Zimmerman, T., Blanco, F. J., et al. (2011) · Bioconjugate Chemistry · doi:10.1021/bc100560c · Cited by 17 · see citing works

Rapid screening for S ‐adenosylmethionine‐dependent methylation products by enzyme‐transferred isotope patterns analysis

Wan, W., Zhao, G., Al‐Saad, K. A., et al. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1335 · Cited by 15 · see citing works

Analysis of heterogeneity in nonspecific PEGylation reactions of biomolecules

Hakem, I. F., Leech, A. M., Bohn, J. A., et al. (2012) · Biopolymers · doi:10.1002/bip.22193 · Cited by 13 · see citing works

Identifying Unknown Enzyme-Substrate Pairs from the Cellular Milieu with Native Mass Spectrometry

Catcott, K. C., Yan, J., Qu, W., Wysocki, V., & Zhou, Z. (2017) · ChemBioChem · doi:10.1002/cbic.201600634 · Cited by 12 · see citing works

Structure-assisted ligand-binding analysis using fluorogenic photoaffinity labeling

Masuda, S., Tomohiro, T., Yamaguchi, S., et al. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.03.008 · Cited by 11 · see citing works

Tandem mass spectrometric method for definitive localization of phosphorylation sites using bromine signature

Kim, J., Kim, J., Oh, J. M., et al. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.03.032 · Cited by 10 · see citing works

Bromine isotopic signature facilitates de novo sequencing of peptides in free‐radical‐initiated peptide sequencing (FRIPS) mass spectrometry

Nam, J., Kwon, H., Jang, I., et al. (2015) · Journal of Mass Spectrometry · doi:10.1002/jms.3539 · Cited by 8 · see citing works

Using Lysine-Reactive Fluorescent Dye for Surface Characterization of a mAb

Lei, M., Kao, Y., & Schöneich, C. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24308 · Cited by 6 · see citing works

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective ligation of azides and terminal alkynes

Rostovtsev, V. V., Green, L. G., Fokin, V. V., & Sharpless, K. B. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020715)41:14

Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products

Vitale, G. A., Geibel, C., Minda, V., Wang, M., Aron, A. T., & Petras, D. (2024) · Natural Product Reports · doi:10.1039/d3np00050h · Cited by 66 · see citing works

Chemical labeling strategies for small molecule natural product detection and isolation

Hughes, C. C. (2021) · Natural Product Reports · doi:10.1039/d0np00034e · Cited by 31 · see citing works

Synthesis of Nanobioconjugates with a Controlled Average Number of Biomolecules between 1 and 100 per Nanoparticle and Observation of Multivalency Dependent Interaction with Proteins and Cells

Saha, A., Basiruddin, S., Maity, A. R., & Jana, N. R. (2013) · Langmuir · doi:10.1021/la402699a · Cited by 40 · see citing works

Purification, Functionalization, and Bioconjugation of Carbon Nanotubes

Luong, J. H. T., Male, K. B., Mahmoud, K. A., et al. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-151-2_32 · Cited by 5 · see citing works

Click Chemistry in the Development of Contrast Agents for Magnetic Resonance Imaging

Hapuarachchige, S., & Artemov, D. (2016) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0000000000000099 · Cited by 11 · see citing works

Functional Targets for Bioconjugation

Hermanson, G. T. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-382239-0.00002-9 · Cited by 65 · see citing works

Site-Specific Biomolecule Labeling with Gold Clusters

Ackerson, C. J., Powell, R., & Hainfeld, J. F. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)81009-2 · Cited by 79 · see citing works