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Ultrasensitive, multiplexed chemoproteomic profiling with soluble activity-dependent proximity ligation

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Developing an Affinity-Based Chemical Proteomics Method to In Situ Capture Amorphous Aggregated Proteome and Profile Its Heterogeneity in Stressed Cells

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Discovery of RNA-Reactive Small Molecules Guides the Design of Electrophilic Modules for RNA-Specific Covalent Binders

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Boronsäuren als bioorthogonale Sonden für zentrenselektives Protein‐Labeling

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Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles

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Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target

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Single-cell chemoproteomics identifies metastatic activity signatures in breast cancer

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Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception

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Synthesis of 5-Hydrazino-2-cyclopentenone Derivatives by a Gold(I)-Catalyzed Cycloisomerization/Hetero-Diels–Alder/Ring-Opening Tandem Reaction of Enynyl Acetates

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Flipping the Switch: Innovations in Inducible Probes for Protein Profiling

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Discovery of Electrophiles and Profiling of Enzyme Cofactors

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Integrating Phenotypic and Chemoproteomic Approaches to Identify Covalent Targets of Dietary Electrophiles in Platelets

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Adenanthin exhibits anti-inflammatory effects by covalently targeting the p65 subunit in the NF-κB signaling pathway

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Chemical Proteomics Probes: Classification, Applications, and Future Perspectives in Proteome‐Wide Studies

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Characterizing metabolic drivers of Clostridioides difficile infection with activity-based hydrazine probes

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Chemoselective Stabilized Triphenylphosphonium Probes for Capturing Reactive Carbonyl Species and Regenerating Covalent Inhibitors with Acrylamide Warheads in Cellulo

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Automation to Enable High-Throughput Chemical Proteomics

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Activity-based ATP analog probes for bacterial histidine kinases

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Chemoproteomics Reveals Unexpected Lysine/Arginine-Specific Cleavage of Peptide Chains as a Potential Protein Degradation Machinery

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Advances in Activity‐Based Protein Profiling of Functional Tyrosines in Proteomes

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A Nucleophilic Activity‐Based Probe Enables Profiling of PLP‐Dependent Enzymes

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Classifying covalent protein binders by their targeted binding site

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Strategies for Competitive Activity‐Based Protein Profiling in Small Molecule Inhibitor Discovery and Characterization

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Reactivity of N -acyl hydrazone probes with the mammalian proteome

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Quantitative Profiling of Protein-Derived Electrophilic Cofactors in Bacterial Cells with a Hydrazine-Derived Probe

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JMod: Joint modeling of mass spectra for empowering multiplexed DIA proteomicsPreprint

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Secernin‐2 Stabilizes Histone Methyltransferase KMT2C to Suppress Progression and Confer Therapeutic Sensitivity to PARP Inhibition in Triple‐Negative Breast Cancer

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Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini

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Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma

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A Chemical Probe for Dehydrobutyrine

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Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein C terminiPreprint

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Photoaffinity enabled transcriptome-wide identification of splice modulating small molecule–RNA binding events in native cells

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Descubrimiento de fármacos basado en imagenología de células vivas

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Chemoproteomic Profiling of Phosphoaspartate Modifications in Prokaryotes

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Nature Biotechnology's academic spinouts of 2017

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Mass spectrometry-based candidate substrate and site identification of PTM enzymes

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Proteolysis‐Assisted Cyclization Facilitates Site‐Centric Target Deconvolution of Isothiocyanates

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The right tool for the job: Chemical biology and microbiome science

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The Impact of Chemical Biology on Drug Discovery

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Evaluation and Optimization of Chemically-Cleavable Linkers for Quantitative Mapping of Small Molecule-Protein InteractomesPreprint

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Inhibiting protein synthesis to treat malaria

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Tunable nucleofugality in carbamoyl-bearing covalent cholinesterase inhibitorsPreprint

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Discovery and elucidation of unknown protein modifications : brominated coumarin azide as a probe for alkynes

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A Dual‐Purpose Bromocoumarin Tag Enables Deep Profiling of the Cellular Cysteinome

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Reverse-polarity activity-based protein profiling

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Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymesPreprint

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[Withdrawn] Hydralazine Inhibits Cysteamine Dioxygenase to Treat Preeclampsia and Senesce in GlioblastomaPreprint

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Proteolysis‐Assisted Cyclization Facilitates Site‐Centric Target Deconvolution of Isothiocyanates

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A framework for understanding post-translational modifications of metabolic origin

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BindingDB Entry 50023549: Classifying covalent protein binders by their targeted binding site.

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Discovery of Electrophiles and Profiling of Enzyme Cofactors

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Reverse-polarity activity-based protein profiling

Dettling, S. (2016) · Nature Methods · doi:10.1038/nmeth.4133

Quantitative Profiling of Protein-Derived Electrophilic Cofactors in Bacterial Cells with a Hydrazine-Derived Probe

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Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors

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Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets

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