Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules
Open accessAbstract
We report the synthesis and characterization of phototriggerable polymeric nanoparticles (NPs) for the intracellular delivery of small molecules and proteins to modulate cell activity. For that purpose, several photocleavable linkers have been prepared providing diverse functional groups as anchoring points for biomolecules.
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Light-activatable nanoparticles containing RA that disassemble in minutes after activation by a blue laser at 405 nm have been prepared.
“In that sense, light-activatable nanoparticles containing RA that disassemble in minutes after activation by a blue laser at 405 nm have been prepared25,26,60.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [26]
In chemical interaction, RA is typically conjugated chemically to one of the components of the nanoparticle by biodegradable ester, amide, or disulfide linkages.
“Concerning chemical interaction, RA is typically conjugated chemically to one of the components of the nanoparticle by biodegradable ester50,52, amide26,53–55, or disulfide56 linkages.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [26]
Light-activatable formulations presented higher activity than formulations in which RA was released by passive diffusion because they rapidly saturated nuclear receptors.
“Importantly, these formulations presented higher activity than formulations in which RA was released by passive diffusion (not light triggered) because they rapidly saturated nuclear receptors.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [26]
These cells then secreted extracellular vesicles containing ATRA that interfered with cells supporting the stem cell niche.
“These cells then secreted extracellular vesicles containing ATRA that interfered with cells supporting the stem cell niche.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [26]
The formulation was highly internalized by leukemia-initiating cells and accumulated in the cell cytoplasm.
“The formulation was highly internalized by leukemia-initiating cells and accumulated in the cell cytoplasm.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [26]
Once leukemia-initiating cells transfected with light-activatable nanoparticles containing RA were administered intravenously in leukemic mice they tend to home in the bone marrow, in the proximity of other leukemia cells.
“Once leukemia-initiating cells transfected with light-activatable nanoparticles containing RA were administered intravenously in leukemic mice they tend to home in the bone marrow, in the proximity of other leukemia cells.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [26]
Irradiation of bone marrow with a blue light induced photo-disassembly of the nanoparticles within the cells and consequently their differentiation.
“The irradiation of bone marrow with a blue light induced photo-disassembly of the nanoparticles within the cells and consequently their differentiation.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [26]
We have developed a new platform to target bone marrow, based on light-activatable nanoparticle formulations containing ATRA.
“Recently, we have developed a new platform to target bone marrow, based on light-activatable nanoparticle formulations containing ATRA25,26.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [26]
Linkers may be cleaved by an external trigger such as light, with consequent release of RA.
“In addition, linkers may be cleaved by an external trigger, such as light with the consequent release of RA25,26.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [26]
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Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine
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- Authors
- Jiménez-Balsa, A., Pinto, S., Quartin, E., Lino, M. M., Francisco, V., & Ferreira, L.
- Affiliations
- Centro de Neurociências e Biologia Celular (PT)
- Corresponding author
- Ferreira, Lino
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-04-13
- Volume
- 29
- Issue
- 5
- Pages
- 1485-1489
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W2797759296
- Cited by
- 14
- References
- 29
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Bioconjugate Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Funders
- European Regional Development Fund
- FP7 Ideas: European Research Council (307384)
- Funda??o para a Ci?ncia e a Tecnologia (SFRH/BPD/102103/2014, SFRH/BD/90964/2012)
- Conseller?a de Cultura, Educaci?n e Ordenaci?n Universitaria, Xunta de Galicia (POS-A/2013/055)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- photocleavable linker, intracellular delivery, polymeric nanoparticles, protein delivery, small molecule delivery, biomolecule conjugation
- MeSH terms
- Animals, Cross-Linking Reagents, Delayed-Action Preparations, Pharmaceutical Preparations, Humans, Muramidase, Photolysis, Polymers, Proteins, Ultraviolet Rays, Nanoparticles
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