PCL-Based Shape Memory Polymer Semi-IPNs: The Role of Miscibility in Tuning the Degradation Rate
Open accessAbstract
The utility of poly(ε-caprolactone) (PCL) as a shape memory polymer (SMP) may be improved by accelerating its degradation. Recently, we have reported novel semi-interpenetrating networks (semi-IPNs) composed of cross-linked PCL diacrylate (PCL-DA) and thermoplastic poly( l -lactic acid) (PLLA) that exhibited SMP behavior, accelerated degradation, and enhanced moduli versus the PCL-DA control. Herein, we systematically varied the thermoplastic component of the PCL-based semi-IPNs, incorporating homo- and copolymers based on lactic acid of different M n, hydrophilicity, and crystallinity. Specifically, semicrystalline PLLAs of different M n s (7.5, 15, 30, and 120 kDa) were explored as the thermoplastics in the semi-IPNs. Additionally, to probe crystallinity and hydrophilicity, amorphous (or nearly amorphous) thermoplastics of different hydrophilicities (PDLLA and PLGAs 85:15, 70:30, and 50:50, l -lactide:glycolide mole % ratio) were employed. For all semi-IPNs, the wt % ratio of the cross-linked PCL-DA to thermoplastic was 75:25. The nature of the thermoplastics was linked to semi-IPN miscibility and the trends in accelerated degradation rates.
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Chen, Y., Zhang, J., Zhang, Y., Cao, W., Liu, X., Bao, J., Zhang, X., & Chen, W. (2023) · Journal of Polymer Science · doi:10.1002/pol.20230425 · Cited by 9 · see citing works
- Authors
- Pfau, M. R., McKinzey, K. G., Roth, A. A., & Grunlan, M. A.
- Affiliations
- Texas A&M University (US)
- Corresponding author
- Grunlan, Melissa A.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-05-12
- Volume
- 21
- Issue
- 6
- Pages
- 2493-2501
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- PMC
- PMC8742658
- OpenAlex
- W3025619600
- Cited by
- 58
- References
- 39
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 10 · 2023: 13 · 2022: 7 · 2021: 8 · 2020: 2
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Biomacromolecules (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH NIDCR (1R01DK095101-01A1)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer composites and self-healing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- polycaprolactone, shape memory polymers, semi-interpenetrating polymer network, poly(L-lactic acid), thermoplastic blends, polymer miscibility, degradation rate, molecular weight effects, crystallinity, hydrophilicity, poly(D,L-lactide), polymer networks
- MeSH terms
- Smart Materials, Polyesters, Polymers, Hydrophobic and Hydrophilic Interactions
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