Cited by 58biodegradable polymer synthesis and propertiesPolymer composites and self-healingHydrogels: synthesis, properties, applications

PCL-Based Shape Memory Polymer Semi-IPNs: The Role of Miscibility in Tuning the Degradation Rate

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Pfau, Michaela R., McKinzey, Kelly G., Roth, Abigail A., Grunlan, Melissa A.·2020·Biomacromolecules

Abstract

The utility of poly(ε-caprolactone) (PCL) as a shape memory polymer (SMP) may be improved by accelerating its degradation. Recently, we have reported novel semi-interpenetrating networks (semi-IPNs) composed of cross-linked PCL diacrylate (PCL-DA) and thermoplastic poly( l -lactic acid) (PLLA) that exhibited SMP behavior, accelerated degradation, and enhanced moduli versus the PCL-DA control. Herein, we systematically varied the thermoplastic component of the PCL-based semi-IPNs, incorporating homo- and copolymers based on lactic acid of different M n, hydrophilicity, and crystallinity. Specifically, semicrystalline PLLAs of different M n s (7.5, 15, 30, and 120 kDa) were explored as the thermoplastics in the semi-IPNs. Additionally, to probe crystallinity and hydrophilicity, amorphous (or nearly amorphous) thermoplastics of different hydrophilicities (PDLLA and PLGAs 85:15, 70:30, and 50:50, l -lactide:glycolide mole % ratio) were employed. For all semi-IPNs, the wt % ratio of the cross-linked PCL-DA to thermoplastic was 75:25. The nature of the thermoplastics was linked to semi-IPN miscibility and the trends in accelerated degradation rates.

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Crossref · 10.1021/acs.biomac.0c00454

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Authors
Pfau, M. R., McKinzey, K. G., Roth, A. A., & Grunlan, M. A.
Affiliations
Texas A&M University (US)
Corresponding author
Grunlan, Melissa A.
Venue
Biomacromolecules
Published
2020-05-12
Volume
21
Issue
6
Pages
2493-2501
ISSN
  • 1525-7797 (ISSN-L)
  • 1526-4602
OpenAlex
W3025619600
Cited by
58
References
39
Citations by year
2026: 9 · 2025: 9 · 2024: 10 · 2023: 13 · 2022: 7 · 2021: 8 · 2020: 2
FWCI
1.95
Type
journal article
Language
en
Open access
Locations
  • Biomacromolecules (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH NIDCR (1R01DK095101-01A1)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Physical Sciences › Materials Science › Polymers and Plastics › Polymer composites and self-healing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
polycaprolactone, shape memory polymers, semi-interpenetrating polymer network, poly(L-lactic acid), thermoplastic blends, polymer miscibility, degradation rate, molecular weight effects, crystallinity, hydrophilicity, poly(D,L-lactide), polymer networks
MeSH terms
Smart Materials, Polyesters, Polymers, Hydrophobic and Hydrophilic Interactions

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