The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration
Open accessAbstract
Lipid droplets are highly associated with obesity, diabetes, inflammatory disorders, and cancer. A reliable two-photon dye for specific lipid droplets imaging in live cells and live tissues at ultralow concentration has rarely been reported. In this work, four new aggregation-induced emission luminogens (AIEgens) based on the naphthalene core were designed and synthesized for specific two-photon lipid droplet staining. The new molecules, namely, NAP AIEgens, exhibit large Stokes shift (>110 nm), high solid-state fluorescence quantum yield (up to 30%), good two-photon absorption cross section (45–100 GM at 860 nm), high biocompatibility, and good photostability. They could specifically stain lipid droplets at ultralow concentration (50 nM) in a short time of 15 min. Such ultralow concentration is the lowest value for lipid droplets staining in live cells reported so far. In vitro and ex vivo two-photon imaging of lipid droplets in live cells and live mice liver tissues were successfully demonstrated. In addition, selective visualization of lipid droplets in live mice liver tissues could be achieved at a depth of about 70 μm. These excellent properties render them as promising candidates for investigating lipid droplet-associated physiological and pathological processes in live biological samples.
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Cites
Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole
Luo, J., Xie, Z., Lam, J. W. Y., Cheng, L., Tang, B. Z., Chen, H., Qiu, C., Kwok, H. S., Zhan, X., Liu, Y., et al. (2001) · Chemical Communications · doi:10.1039/b105159h · Cited by 8,358
Self-citationAggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Self-citationSmall-Molecule Two-Photon Probes for Bioimaging Applications
Kim, H. M., & Cho, B. R. (2015) · Chemical Reviews · doi:10.1021/cr5004425 · Cited by 1,047
The biophysics and cell biology of lipid droplets
Thiam, A. R., Farese Jr, R. V., & Walther, T. C. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3699 · Cited by 986
Cited by
Supramolecular materials based on AIE luminogens (AIEgens): construction and applications
Li, J., Wang, J., Li, H., Song, N., Wang, D., & Tang, B. Z. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00495e · Cited by 741
Self-citationMolecular photoswitches in aqueous environments
Volarić, J., Szymanski, W., Simeth, N. A., & Feringa, B. L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00547a · Cited by 438
Duan, Q., Zheng, G., Li, Z., Cheng, K., Zhang, J., Yang, L., Jiang, Y., Zhang, H., He, J., & Sun, H. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb01279f · Cited by 44
Metadata
- Authors
- Niu, G., Zhang, R., Kwong, J. P. C., Lam, J. W. Y., Chen, C., Wang, J., Chen, Y., Feng, X., Kwok, R. T. K., Sung, H. H.-Y., Williams, I. D., Elsegood, M. R. J., Qu, J., Ma, C., Wong, K. S., Yu, X., & Tang, B. Z.
- Venue
- Chemistry of Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-07-02
- Volume
- 30
- Issue
- 14
- Pages
- 4778-4787
- ISSN
- 0897-4756 (ISSN-L)
- 1520-5002
- OpenAlex
- W2811257400
- Cited by
- 180
- References
- 4
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Niu, G., Zhang, R., Kwong, J. P. C., Lam, J. W. Y., Chen, C., Wang, J., Chen, Y., Feng, X., Kwok, R. T. K., Sung, H. H.-Y., Williams, I. D., Elsegood, M. R. J., Qu, J., Ma, C., Wong, K. S., Yu, X., & Tang, B. Z. (2018). Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration. Chemistry of Materials. https://doi.org/10.1021/acs.chemmater.8b01943
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