The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Concentration Ranges of Antibacterial Cations for Showing the Highest Antibacterial Efficacy but the Least Cytotoxicity against Mammalian Cells: Implications for a New Antibacterial Mechanism
Open accessAbstract
Antibacterial metal ions, such as Ag(+), Zn(2+) and Cu(2+), have been extensively used in medical implants and devices due to their strong broad spectrum of antibacterial activity. However, it is still a controversial issue as to whether they can show the desired antibacterial activity while being toxic to mammalian cells. It is very important to balance their antibacterial effectiveness with minimal damage to mammalian cells. Toward this end, this study is to identify the suitable concentrations of these three ions at which they can effectively kill two types of clinically relevant bacteria (Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli)) but show no obvious cytotoxicity on fibroblasts. Such concentration ranges are found to be 2.5 × 10(-7) M-10(-6) M, 10(-5) M-10(-4) M, and 10(-5) M-10(-4) M for Ag(+), Zn(2+), and Cu(2+), respectively. Investigation of their antibacterial mechanism shows that these three metal ions all show antibacterial property through a mechanism of damaging bacterial cell membranes by the generation of reactive oxygen species but surprisingly preserving the integrity of bacterial genomic DNA. The encouraging results indicate that antibacterial metal ions with controlled concentrations can bring considerable benefits to biomedical applications.
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Cites
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Cited by
Polydopamine antibacterial materials
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Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies
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Metadata
- Authors
- Ning, C., Wang, X., Li, L., Zhu, Y., Li, M., Yu, P., Zhou, L., Zhou, Z., Chen, J., Tan, G., Zhang, Y., Wang, Y., & Mao, C.
- Venue
- Chemical Research in Toxicology
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-08-10
- Volume
- 28
- Issue
- 9
- Pages
- 1815-1822
- ISSN
- 0893-228X (ISSN-L)
- 1520-5010
- OpenAlex
- W2437376282
- Cited by
- 344
- References
- 48
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Ning, C., Wang, X., Li, L., Zhu, Y., Li, M., Yu, P., Zhou, L., Zhou, Z., Chen, J., Tan, G., Zhang, Y., Wang, Y., & Mao, C. (2015). Concentration Ranges of Antibacterial Cations for Showing the Highest Antibacterial Efficacy but the Least Cytotoxicity against Mammalian Cells: Implications for a New Antibacterial Mechanism. Chemical Research in Toxicology. https://doi.org/10.1021/acs.chemrestox.5b00258
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