Polydopamine antibacterial materials
Abstract
Recently, the development of polydopamine (PDA) has demonstrated numerous excellent performances in free radical scavenging, UV shielding, photothermal conversion, and biocompatibility. These unique properties enable PDA to be widely used as efficient antibacterial materials for various applications. Accordingly, PDA antibacterial materials mainly include free-standing PDA materials and PDA-based composite materials. In this review, an overview of PDA antibacterial materials is provided to summarize these two types of antibacterial materials in detail, including the fabrication strategies and antibacterial mechanisms. The future development and challenges of PDA in this field are also presented. It is hoped that this review will provide an insight into the future development of antibacterial functional materials based on PDA.
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These intelligent PDA-based delivery systems attenuate alveolar bone resorption.
“Specifically, these systems have been shown to suppress periodontal inflammation, attenuate alveolar bone resorption, and promote periodontal tissue regeneration.68,73,78”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [78]
These intelligent PDA-based delivery systems suppress periodontal inflammation.
“Specifically, these systems have been shown to suppress periodontal inflammation, attenuate alveolar bone resorption, and promote periodontal tissue regeneration.68,73,78”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [78]
These intelligent PDA-based delivery systems promote periodontal tissue regeneration.
“Specifically, these systems have been shown to suppress periodontal inflammation, attenuate alveolar bone resorption, and promote periodontal tissue regeneration.68,73,78”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [78]
Extensive in vitro release studies and in vivo evaluations, including rat models of periodontitis, have consistently demonstrated the effectiveness of these intelligent PDA-based delivery platforms.
“Extensive in vitro release studies and in vivo evaluations, including rat models of periodontitis, have consistently demonstrated the effectiveness of these intelligent PDA-based delivery platforms.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [78]
In vitro antibacterial assays, simplified biofilm models, release studies, and selected animal models show that PDA-based systems can achieve biofilm inhibition, ROS regulation, localized drug release, photothermal/photodynamic antibacterial effects, and inflammation control.
“In vitro antibacterial assays, simplified biofilm models, release studies, and selected animal models show biofilm inhibition, ROS regulation, localized drug release, photothermal/photodynamic antibacterial effects, and inflammation control.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [78]
Cites
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Dopamine Modified Organic–Inorganic Hybrid Coating for Antimicrobial and Osteogenesis
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Yan, M., Liang, W., Du, L., Guo, R., Cao, Y., Ni, S., Zhong, Y., Zhang, K., Qu, K., Qin, X., et al. (2023) · Nanomedicine · doi:10.2217/nnm-2023-0245 · Cited by 1 · see citing works
Yang, Z., Song, W., Lv, L., Zhai, S., Liu, Y., Cui, H., Li, X., Gao, F., & Chu, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s611922
- Authors
- Fu, Y., Yang, L., Zhang, J., Hu, J., Duan, G., Liu, X., Li, Y., & Gu, Z.
- Affiliations
- University of Akron (US)
- Nanjing Forestry University (CN)
- Zhengzhou University (CN)
- Corresponding author
- Li, Yiwen
- Gu, Zhipeng
- Venue
- Materials Horizons
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Volume
- 8
- Issue
- 6
- Pages
- 1618-1633
- ISSN
- 2051-6347 (ISSN-L)
- 2051-6355
- OpenAlex
- W3125320754
- Cited by
- 546
- References
- 4
- Citations by year
- 2026: 66 · 2025: 138 · 2024: 126 · 2023: 108 · 2022: 80 · 2021: 28
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Materials Horizons (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21774079, 21975167)
- National Key Research and Development Program of China (2019YFA0904500)
- Fundamental Research Funds for the Central Universities
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- polydopamine, antibacterial materials, antibacterial mechanism, fabrication techniques, free radical scavenging, UV protection, photothermal conversion, biocompatibility
- MeSH terms
- Anti-Bacterial Agents, Indoles, Polymers
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