The DOI matches its Crossref record; 1,197 of the 1,199 references it cites were found in a registry or an index.
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Abstract
This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the use of light combined with a light-activated chemical, referred to as a PS. Attractively, PDT is one of the alternatives to conventional cancer treatment due to its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although the concept of photosensitizer-based photodynamic therapy has been widely adopted for clinical trials and bioimaging, until now, to our surprise, there has been no relevant review article on rational designs of organic PSs for PDT. Furthermore, most of published review articles in PDT focused on nanomaterials and nanotechnology based on traditional PSs. Therefore, this review aimed at reporting recent strategies to develop innovative organic photosensitizers for enhanced photodynamic therapy, with each example described in detail instead of providing only a general overview, as is typically done in previous reviews of PDT, to provide intuitive, vivid, and specific insights to the readers.
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In the citing paper
“PDT utilizing next-generation metal-based photosensitizers with extended excitation and emission spectra holds significant promise for antibacterial applications16,241.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [16]
In the citing paper
“This is a very important detail because phototoxicity from PDT is dependent on both oxygen tension and photosensitizer concentration. 440 , 441”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [440]
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Theranostic Fluorescent Probes
Sharma, A. K., Verwilst, P., Li, M., Ma, D., Singh, N., Yoo, J., Kim, Y., Yang, Y., Zhu, J., Huang, H., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00778 · Cited by 512
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Self-citation
Metadata
- Authors
- Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J.
- Affiliations
- Pukyong National University (KR)
- Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea
- Ewha Womans University (KR)
- Corresponding author
- Lee, Songyi
- Yoon, Juyoung
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-09-28
- Volume
- 121
- Issue
- 21
- Pages
- 13454-13619
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W3204360553
- Cited by
- 1,813
- References
- 1,199
- Citations by year
- 2026: 308 · 2025: 457 · 2024: 466 · 2023: 338 · 2022: 240 · 2021: 4
- FWCI
- 42.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (2012R1A3A2048814, 2017R1A6A3A04004954, 2021R1A6A1A10039823)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
- Keywords
- photosensitizers, photodynamic therapy, organic photosensitizers, reactive oxygen species, cancer therapy, rational design
- MeSH terms
- Humans, Neoplasms, Photochemotherapy, Photosensitizing Agents, Reactive Oxygen Species, Nanotechnology
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