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Cited by 103Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsLuminescence and Fluorescent Materials

NIR‐II Light Activated Photosensitizer with Aggregation‐Induced Emission for Precise and Efficient Two‐Photon Photodynamic Cancer Cell Ablation

Wang, Shaowei, Chen, Huan, Liu, Jie, Chen, Chengjian, Liu, Bin·2020·Advanced Functional Materials
DOI 10.1002/adfm.202002546
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Abstract

Near infrared (NIR) light excitable photosensitizers are highly desirable for photodynamic therapy with deep penetration. Herein, a NIR‐II light (1200 nm) activated photosensitizer TQ‐BTPE is designed with aggregation‐induced singlet oxygen (1O2) generation for two‐photon photodynamic cancer cell ablation. TQ‐BTPE shows good two‐photon absorption and bright aggregation‐induced NIR‐I emission upon NIR‐II laser excitation. The 1O2 produced by TQ‐BTPE in an aqueous medium is much more efficient than that of commercial photosensitizer Ce6 under white light irradiation. Upon NIR‐II excitation, the two‐photon photosensitization of TQ‐BTPE is sevenfold higher than that of Ce6. The TQ‐BTPE molecules internalized by HeLa cells are mostly located in lysosomes as small aggregate dots with homogeneous distribution inside the cells, which favors efficient photodynamic cell ablation. The two‐photon photosensitization of TQ‐BTPE upon NIR‐I and NIR‐II excitation shows higher 1O2 generation efficiency than under NIR‐I excitation owing to the larger two‐photon absorption cross section at 920 nm. However, NIR‐II light exhibits better biological tissue penetration capability after passing through a fresh pork tissue, which facilitates stronger two‐photon photosensitization and better cancer cell ablation performance. This work highlights the promise of NIR‐II light excitable photosensitizers for deep‐tissue photodynamic therapy.

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Crossref · 10.1002/adfm.202002546

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3 of 3 references verified0 citation errors · 0 not checkable

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  • Each methylene unit inserted between donor and acceptor typically induces a red-shift of ~100 nm.

    “A general rule, as exemplified in cyanine dyes, is that each methylene unit inserted between donor and acceptor typically induces a red-shift of ~100 nm111–123.”

    From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [118]

  • Higher molecular planarity, stronger donor strength, and increasing acceptor electron affinity in BBTD-based systems synergistically enhance conjugation, intramolecular charge transfer strength, and excited-state stability, resulting in narrowed bandgaps and superior NIR-II optical performance.

    “Recent studies have demonstrated that higher molecular planarity, stronger donor strength, and increasing acceptor electron affinity in BBTD-based systems can synergistically enhance conjugation, ICT strength, and excited-state stability, which collectively result in narrowed bandgaps and superior NIR-II optical performance117–121.”

    From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [118]

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Authors
Wang, S., Chen, H., Liu, J., Chen, C., & Liu, B.
Affiliations
  • National University of Singapore (SG)
  • Nanjing Tech University (CN)
  • Tianjin University (CN)
Corresponding author
Liu, Bin
ORCID
Venue
Advanced Functional Materials
Publisher
Wiley
Published
2020-06-05
Volume
30
Issue
30
ISSN
  • 1616-301X (ISSN-L)
  • 1616-3028
DOI
10.1002/adfm.202002546
OpenAlex
W3033696562
Cited by
103
References
3
Citations by year
2026: 4 · 2025: 9 · 2024: 12 · 2023: 15 · 2022: 31 · 2021: 30 · 2020: 2
FWCI
10.98
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Advanced Functional Materials (publishedVersion)
  • National University of Singapore (submittedVersion)
Funders
  • National Research Foundation Singapore (R279‐000‐483‐281, R279‐000‐444‐281)
  • National University of Singapore (R279‐000‐482‐133)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Keywords
NIR-II light, photosensitizers, aggregation-induced emission, two-photon photodynamic therapy, singlet oxygen generation, cancer cell ablation, deep tissue penetration, two-photon absorption, lysosomal targeting, HeLa cells, tissue penetration, photosensitizer design

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