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Conformational Dynamics of Intrinsically Disordered Proteins Regulate Biomolecular Condensate Chemistry
Open accessAbstract
Motions in biomolecules are critical for biochemical reactions. In cells, many biochemical reactions are executed inside of biomolecular condensates formed by ultradynamic intrinsically disordered proteins. A deep understanding of the conformational dynamics of intrinsically disordered proteins in biomolecular condensates is therefore of utmost importance but is complicated by diverse obstacles. Here we review emerging data on the motions of intrinsically disordered proteins inside of liquidlike condensates. We discuss how liquid-liquid phase separation modulates internal motions across a wide range of time and length scales. We further highlight the importance of intermolecular interactions that not only drive liquid-liquid phase separation but appear as key determinants for changes in biomolecular motions and the aging of condensates in human diseases. The review provides a framework for future studies to reveal the conformational dynamics of intrinsically disordered proteins in the regulation of biomolecular condensate chemistry.
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“Disordered proteins (regions) are characterized by broad and heterogeneous ensembles where the differences in the relative conformational stabilities are small, or even minor and the barriers are low.”
From AlphaFold, Artificial Intelligence (AI), and Allostery (2022) · cites this paper as [127]
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Metadata
- Authors
- Abyzov, A., Blackledge, M., & Zweckstetter, M.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Zweckstetter, Markus
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-02-18
- Volume
- 122
- Issue
- 6
- Pages
- 6719-6748
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- PMC
- PMC8949871
- OpenAlex
- W4212888384
- Cited by
- 215
- References
- 259
- Citations by year
- 2026: 44 · 2025: 63 · 2024: 60 · 2023: 35 · 2022: 13
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Chemical Reviews (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DZNE Pub (submittedVersion, cc-by)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 860/B02, SPP2191, ZW 71/9-1)
- H2020 European Research Council (787679)
- Volkswagen Foundation (AZ 98188)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- intrinsically disordered proteins, biomolecular condensates, conformational dynamics, liquid-liquid phase separation, intermolecular interactions
- MeSH terms
- Biomolecular Condensates, Humans, Molecular Conformation, Intrinsically Disordered Proteins
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