The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Near-Infrared Fluorescent Proteins, Biosensors, and Optogenetic Tools Engineered from Phytochromes
Abstract
Phytochrome photoreceptors absorb far-red and near-infrared (NIR) light and regulate light responses in plants, fungi, and bacteria. Their multidomain structure and autocatalytic incorporation of linear tetrapyrrole chromophores make phytochromes attractive molecular templates for the development of light-sensing probes. A subclass of bacterial phytochromes (BphPs) utilizes heme-derived biliverdin tetrapyrrole, which is ubiquitous in mammalian tissues, as a chromophore. Because biliverdin possesses the largest electron-conjugated chromophore system among linear tetrapyrroles, BphPs exhibit the most NIR-shifted spectra that reside within the NIR tissue transparency window. Here we analyze phytochrome structure and photochemistry to describe the molecular mechanisms by which they function. We then present strategies to engineer BphP-based NIR fluorescent proteins and review their properties and applications in modern imaging technologies. We next summarize designs of reporters and biosensors and describe their use in the detection of protein-protein interactions, proteolytic activities, and posttranslational modifications. Finally, we provide an overview of optogenetic tools developed from phytochromes and describe their use in light-controlled cell signaling, gene expression, and protein localization. Our review provides guidelines for the selection of NIR probes and tools for noninvasive imaging, sensing, and light-manipulation applications, specifically focusing on probes developed for use in mammalian cells and in vivo.
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Cites
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PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light
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PHYTOCHROME STRUCTURE AND SIGNALING MECHANISMS
Rockwell, N. C., Su, Y.-S., & Lagarias, J. C. (2006) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.56.032604.144208 · Cited by 1,088
Spatiotemporal control of cell signalling using a light-switchable protein interaction
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Protein tagging and detection with engineered self-assembling fragments of green fluorescent protein
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Bright and stable near-infrared fluorescent protein for in vivo imaging
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Self-citationMammalian Expression of Infrared Fluorescent Proteins Engineered from a Bacterial Phytochrome
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Engineering Escherichia coli to see light
Levskaya, A., Chevalier, A. A., Tabor, J. J., Simpson, Z. B., Lavery, L. A., Levy, M., Davidson, E. A., Scouras, A., Ellington, A. D., Marcotte, E. M., et al. (2005) · Nature · doi:10.1038/nature04405 · Cited by 624
A light-switchable gene promoter system
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Phytochrome Signaling Mechanisms
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Recent advances in neurotechnologies with broad potential for neuroscience research
Vázquez-Guardado, A., Yang, Y., Bandodkar, A. J., & Rogers, J. A. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00739-8 · Cited by 202
Heyes, D. J., Hardman, S. J. O., Pedersen, M. N., Woodhouse, J., De La Mora, E., Wulff, M., Weik, M., Cammarata, M., Scrutton, N. S., & Schirò, G. (2019) · Communications Biology · doi:10.1038/s42003-018-0242-0 · Cited by 132
Molecular Imaging and Nanotechnology—Emerging Tools in Diagnostics and Therapy
Woźniak, M., Płoska, A., Siekierzycka, A., Dobrucki, L. W., Kalinowski, L., & Dobrucki, I. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052658 · Cited by 59
Mukherjee, S., Manna, P., Douglas, N., Chapagain, P. P., & Jimenez, R. (2023) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.2c05584 · Cited by 8
Metadata
- Authors
- Chernov, K. G., Redchuk, T. A., Omelina, E. S., & Verkhusha, V. V.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-04-12
- Volume
- 117
- Issue
- 9
- Pages
- 6423-6446
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2605999716
- Cited by
- 264
- References
- 101
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chernov, K. G., Redchuk, T. A., Omelina, E. S., & Verkhusha, V. V. (2017). Near-Infrared Fluorescent Proteins, Biosensors, and Optogenetic Tools Engineered from Phytochromes. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.6b00700
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